SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8NWC9

- GCSPA_STAAW

UniProt

Q8NWC9 - GCSPA_STAAW

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, MW1488
Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-1512-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:MW1488
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_0000166975Add
BLAST

Proteomic databases

PRIDEiQ8NWC9.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi196620.MW1488.

Structurei

3D structure databases

ProteinModelPortaliQ8NWC9.
SMRiQ8NWC9. Positions 4-358.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NWC9-1 [UniParc]FASTAAdd to Basket

« Hide

MSHRYIPLTE KDKQEMLQTI GAKSIGELFG DVPSDILLNR DLNIAEGEAE    50
TTLLRRLNRI ASKNITKETH TSFLGAGVYD HYAPSVVDAM ISRSEFYTAY 100
TPYQPEISQG ELQAIFEFQT LICELTDMDV ANSSMYDGMT SFAEACILAF 150
SQTKKNKIVV SKGLHYQALQ VLHTYAKTRK EFEVVEIDLD GTVTDLKKLE 200
AAVDDETAAV AVQYPNFYGS IEDLEKIHSF IEDKKALFIV YANPLALGLL 250
TPPGSFGADI VVGDTQPFGI PAQFGGPHCG YFATTKKLMR KVPGRLVGQT 300
QDDEGNRGFV LTLQAREQHI RRDKATSNIC SNQALNALAS SIAMSALGKQ 350
GIYDIAVQNI EHANYAKQQF IKKGFEVLDG TSFNEFVVKF DKPIQQVNEE 400
LVKYNIIGGF DLGVVSDDFK NHMLIAVTEL RTKDEIDTFV EKAGELND 448
Length:448
Mass (Da):49,716
Last modified:October 1, 2002 - v1
Checksum:i7B948E5D85C80553
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB95353.1.
RefSeqiNP_646305.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95353; BAB95353; BAB95353.
GeneIDi1003600.
KEGGisam:MW1488.
PATRICi19569586. VBIStaAur44266_1554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB95353.1 .
RefSeqi NP_646305.1. NC_003923.1.

3D structure databases

ProteinModelPortali Q8NWC9.
SMRi Q8NWC9. Positions 4-358.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196620.MW1488.

Proteomic databases

PRIDEi Q8NWC9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB95353 ; BAB95353 ; BAB95353 .
GeneIDi 1003600.
KEGGi sam:MW1488.
PATRICi 19569586. VBIStaAur44266_1554.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci SAUR196620:GJ9Z-1512-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiGCSPA_STAAW
AccessioniPrimary (citable) accession number: Q8NWC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi