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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-1512-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:MW1488
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_0000166975Add
BLAST

Proteomic databases

PRIDEiQ8NWC9.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8NWC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiSNICSNE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NWC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRYIPLTE KDKQEMLQTI GAKSIGELFG DVPSDILLNR DLNIAEGEAE
60 70 80 90 100
TTLLRRLNRI ASKNITKETH TSFLGAGVYD HYAPSVVDAM ISRSEFYTAY
110 120 130 140 150
TPYQPEISQG ELQAIFEFQT LICELTDMDV ANSSMYDGMT SFAEACILAF
160 170 180 190 200
SQTKKNKIVV SKGLHYQALQ VLHTYAKTRK EFEVVEIDLD GTVTDLKKLE
210 220 230 240 250
AAVDDETAAV AVQYPNFYGS IEDLEKIHSF IEDKKALFIV YANPLALGLL
260 270 280 290 300
TPPGSFGADI VVGDTQPFGI PAQFGGPHCG YFATTKKLMR KVPGRLVGQT
310 320 330 340 350
QDDEGNRGFV LTLQAREQHI RRDKATSNIC SNQALNALAS SIAMSALGKQ
360 370 380 390 400
GIYDIAVQNI EHANYAKQQF IKKGFEVLDG TSFNEFVVKF DKPIQQVNEE
410 420 430 440
LVKYNIIGGF DLGVVSDDFK NHMLIAVTEL RTKDEIDTFV EKAGELND
Length:448
Mass (Da):49,716
Last modified:October 1, 2002 - v1
Checksum:i7B948E5D85C80553
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95353.1.
RefSeqiWP_000019687.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95353; BAB95353; BAB95353.
GeneIDi23197343.
KEGGisam:MW1488.
PATRICi19569586. VBIStaAur44266_1554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95353.1.
RefSeqiWP_000019687.1. NC_003923.1.

3D structure databases

ProteinModelPortaliQ8NWC9.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8NWC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB95353; BAB95353; BAB95353.
GeneIDi23197343.
KEGGisam:MW1488.
PATRICi19569586. VBIStaAur44266_1554.

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiSNICSNE.
OrthoDBiEOG6XWV3B.

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-1512-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiGCSPA_STAAW
AccessioniPrimary (citable) accession number: Q8NWC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.