Q8NWA1 (AROE_STAAW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	MW1547

Organism

Staphylococcus aureus (strain MW2) [Complete proteome] [HAMAP]

Taxonomic identifier

196620 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000136035
Regions
	Nucleotide binding	124 – 128	5	NADP By similarity
Sites
	Active site	64	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8NWA1 [UniParc]. Last modified October 19, 2002. Version 1. Checksum: 26860D86F0739262	FASTA	268	29,897
	10 20 30 40 50 60 MKFAVIGNPI SHSLSPVMHR ANFNSLGLDD TYEALNIPIE DFHLIKEIIS KKELDGFNIT 70 80 90 100 110 120 IPHKERIIPY LDHVDEQAIN AGAVNTVLIK DDKWIGYNTD GIGYVKGLHS VYPDLENAYI 130 140 150 160 170 180 LILGAGGASK GIAYELAKFV KPKLTVANRT MARFESWNLN INQISLADAE KYLAEFDIVI 190 200 210 220 230 240 NTTPAGMAGN NESIINLKHL SPNTLMSDIV YIPYKTPILE EAERKGNHIY NGLDMFVYQG 250 260 AESFKIWTNK DADINSMKTA VLQQLKGE

References

[1]

"Genome and virulence determinants of high virulence community-acquired MRSA." Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K. Lancet 359:1819-1827(2002) [PubMed: 12044378] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MW2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000033 Genomic DNA. Translation: BAB95412.1.
RefSeq	NP_646364.1. NC_003923.1.
3D structure databases
ProteinModelPortal	Q8NWA1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NWA1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000026495; EBSTAP00000025534; EBSTAG00000026494.
GeneID	1003659.
GenomeReviews	Gene locus MW1547 in contig BA000033_GR.
KEGG	sam:MW1547.
PATRIC	19569706. VBIStaAur44266_1614.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
GeneTree	EBGT00050000025479.
HOGENOM	HBG553408.
OMA	TLFMKKG.
PhylomeDB	Q8NWA1.
ProtClustDB	CLSK885454.
Enzyme and pathway databases
BioCyc	SAUR196620:MW1547-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_STAAW

Accession

Primary (citable) accession number: Q8NWA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	October 19, 2002
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program