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Q8NW61

- IDH_STAAW

UniProt

Q8NW61 - IDH_STAAW

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei94 – 941NADPBy similarity
Binding sitei103 – 1031SubstrateBy similarity
Binding sitei105 – 1051SubstrateBy similarity
Binding sitei109 – 1091SubstrateBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei143 – 1431SubstrateBy similarity
Sitei150 – 1501Critical for catalysisBy similarity
Sitei220 – 2201Critical for catalysisBy similarity
Metal bindingi310 – 3101Magnesium or manganeseBy similarity
Binding sitei357 – 3571NADP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei396 – 3961NADPBy similarity
Binding sitei400 – 4001NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi344 – 3507NADPBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-1661-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Synonyms:citC
Ordered Locus Names:MW1638
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Isocitrate dehydrogenase [NADP]PRO_0000083564Add
BLAST

Proteomic databases

PRIDEiQ8NW61.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi196620.MW1638.

Structurei

3D structure databases

ProteinModelPortaliQ8NW61.
SMRiQ8NW61. Positions 3-421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiCAVHKAN.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NW61-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAEKITQGT EGLNVPNEPI IPFIIGDGIG PDIWKAASRV IDAAVEKAYN
60 70 80 90 100
GEKRIEWKEV LAGQKAFDTT GEWLPQETLD TIKEYLIAVK GPLTTPIGGG
110 120 130 140 150
IRSLNVALRQ ELDLFTCLRP VRWFKGVPSP VKRPQDVDMV IFRENTEDIY
160 170 180 190 200
AGIEFKEGTT EVKKVIDFLQ NEMGATNIRF PETSGIGIKP VSKEGTERLV
210 220 230 240 250
RAAIQYAIDN NRKSVTLVHK GNIMKFTEGS FKQWGYDLAL SEFGDQVFTW
260 270 280 290 300
QQYDEIVEKE GRDAANAAQE KAEKEGKIII KDSIADIFLQ QILTRPAEHD
310 320 330 340 350
VVATMNLNGD YISDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY
360 370 380 390 400
AGLNKVNPSS VILSSVLMLE HLGWQEAADK ITDSIEDTIA SKVVTYDFAR
410 420
LMDGAEEVST SAFADELIKN LK
Length:422
Mass (Da):46,437
Last modified:October 1, 2002 - v1
Checksum:i11AE808D40093BC7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB95503.1.
RefSeqiNP_646455.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95503; BAB95503; BAB95503.
GeneIDi1003750.
KEGGisam:MW1638.
PATRICi19569890. VBIStaAur44266_1706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB95503.1 .
RefSeqi NP_646455.1. NC_003923.1.

3D structure databases

ProteinModelPortali Q8NW61.
SMRi Q8NW61. Positions 3-421.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196620.MW1638.

Proteomic databases

PRIDEi Q8NW61.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB95503 ; BAB95503 ; BAB95503 .
GeneIDi 1003750.
KEGGi sam:MW1638.
PATRICi 19569890. VBIStaAur44266_1706.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi CAVHKAN.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci SAUR196620:GJ9Z-1661-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiIDH_STAAW
AccessioniPrimary (citable) accession number: Q8NW61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2002
Last modified: October 1, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3