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Q8NW39

- ISDH_STAAW

UniProt

Q8NW39 - ISDH_STAAW

Protein

Iron-regulated surface determinant protein H

Gene

isdH

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone By similarity.By similarity

    Enzyme and pathway databases

    BioCyciSAUR196620:GJ9Z-1696-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iron-regulated surface determinant protein H
    Alternative name(s):
    Haptoglobin receptor A
    Staphylococcus aureus surface protein I
    Gene namesi
    Name:isdH
    Synonyms:harA, sasI
    Ordered Locus Names:MW1674
    OrganismiStaphylococcus aureus (strain MW2)
    Taxonomic identifieri196620 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000418: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cell wall Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-KW
    3. membrane Source: InterPro

    Keywords - Cellular componenti

    Cell wall, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4040Sequence AnalysisAdd
    BLAST
    Chaini41 – 864824Iron-regulated surface determinant protein HPRO_0000285189Add
    BLAST
    Propeptidei865 – 89531Removed by sortaseSequence AnalysisPRO_0000285190Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei864 – 8641Pentaglycyl murein peptidoglycan amidated threonineSequence Analysis

    Keywords - PTMi

    Peptidoglycan-anchor

    Interactioni

    Protein-protein interaction databases

    STRINGi196620.MW1674.

    Structurei

    Secondary structure

    1
    895
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi90 – 934
    Helixi97 – 993
    Beta strandi109 – 1124
    Beta strandi114 – 1174
    Helixi125 – 1306
    Beta strandi133 – 1386
    Beta strandi144 – 1518
    Turni153 – 1553
    Beta strandi156 – 16712
    Beta strandi171 – 1755
    Turni178 – 1803
    Beta strandi183 – 1897
    Beta strandi195 – 20410
    Beta strandi209 – 2124
    Beta strandi216 – 2216
    Turni326 – 3283
    Helixi330 – 3334
    Turni337 – 3393
    Beta strandi347 – 3526
    Beta strandi354 – 3574
    Beta strandi361 – 3633
    Helixi365 – 3695
    Beta strandi373 – 3808
    Beta strandi383 – 39210
    Turni393 – 3953
    Beta strandi396 – 4038
    Beta strandi411 – 4166
    Turni417 – 4204
    Beta strandi421 – 4277
    Beta strandi434 – 44310
    Turni444 – 4463
    Beta strandi447 – 46014
    Helixi472 – 48615
    Helixi490 – 50314
    Helixi506 – 52924

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LHRNMR-A467-543[»]
    3SZKX-ray3.01C/F86-229[»]
    4FC3X-ray2.26E321-464[»]
    ProteinModelPortaliQ8NW39.
    SMRiQ8NW39. Positions 86-229, 326-467, 542-657.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini105 – 232128NEAT 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini345 – 471127NEAT 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini543 – 660118NEAT 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi861 – 8655LPXTG sorting signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi698 – 77982Asp-richAdd
    BLAST

    Domaini

    The NEAT 1 domain binds with higher affinity than the NEAT 2 domain haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin.By similarity

    Sequence similaritiesi

    Belongs to the IsdH family.Curated
    Contains 3 NEAT domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000280077.
    OMAiVQTGQED.
    OrthoDBiEOG6RNQ8T.

    Family and domain databases

    InterProiIPR019930. Haptoglobin-bd_HarA.
    IPR019931. LPXTG_anchor.
    IPR006635. NEAT_dom.
    IPR005877. YSIRK_signal_dom.
    [Graphical view]
    PfamiPF05031. NEAT. 3 hits.
    PF04650. YSIRK_signal. 1 hit.
    [Graphical view]
    SMARTiSM00725. NEAT. 3 hits.
    [Graphical view]
    TIGRFAMsiTIGR03658. IsdH_HarA. 1 hit.
    TIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEiPS50978. NEAT. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8NW39-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKHHPKLRS FYSIRKSILG VASVIVSTLF LITSQHQAQA AENTNTSDKI    50
    SENQNNNATT TQPPKDTNQT QPATQPANTA KTYPAADESL KDAIKDPALE 100
    NKEHDIGPRE QVNFQLLDKN NETQYYHFFS IKDPADVYYT KKKAEVELDI 150
    NTASTWKKFE VYENNQKLPV RLVSYSPVPE DHAYIRFPVS DGTQELKIVS 200
    STQIDDGEET NYDYTKLVFA KPIYNDPSLV KSDTNDAVVT NDQSSSDASN 250
    QTNTNTSNQN TSTINNANNQ PQATTNMSQP AQPKSSANAD QASSQPAHET 300
    NSNGNTNDKT NESSNQSDVN QQYPPADESL QDAIKNPAII DKEHTADNWR 350
    PIDFQMKNDK GERQFYHYAS TVEPATVIFT KTGPIIELGL KTASTWKKFE 400
    VYEGDKKLPV ELVSYDSDKD YAYIRFPVSN GTREVKIVSS IEYGENIHED 450
    YDYTLMVFAQ PITNNPDDYV DEETYNLQKL LAPYHKAKTL ERQVYELEKL 500
    QEKLPEKYKA EYKKKLDQTR VELADQVKSA VTEFENVTPT NDQLTDVQEA 550
    HFVVFESEEN SESVMDGFVE HPFYTATLNG QKYVVMKTKD DSYWKDLIVE 600
    GKRVTTVSKD PKNNSRTLIF PYIPDKAVYN AIVKVVVANI GYEGQYHVRI 650
    INQDINTKDD DTSQNNTSEP LNVQTGQEGK VADTDVAENS STATNPKDAS 700
    DKADVIEPDS DVVKDADNNI DKDVQHDVDH LSDMSDNNHF DKYDLKEMDT 750
    QIAKDTDRNV DKGADNSVGM SSNVDTDKDS NKNKDKVIQL NHIADKNNHN 800
    GKAAKLDVVK QNYNNTDKVT DKKTTEHLPS DIHKTVDKTV KTKEKAGTPS 850
    KENKLSQSKM LPKTGETTSS QSWWGLYALL GMLALFIPKF RKESK 895
    Length:895
    Mass (Da):100,847
    Last modified:October 1, 2002 - v1
    Checksum:i797BB0D67F9A0559
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000033 Genomic DNA. Translation: BAB95538.1.
    RefSeqiNP_646490.1. NC_003923.1.

    Genome annotation databases

    EnsemblBacteriaiBAB95538; BAB95538; BAB95538.
    GeneIDi1003785.
    KEGGisam:MW1674.
    PATRICi19569962. VBIStaAur44266_1742.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000033 Genomic DNA. Translation: BAB95538.1 .
    RefSeqi NP_646490.1. NC_003923.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LHR NMR - A 467-543 [» ]
    3SZK X-ray 3.01 C/F 86-229 [» ]
    4FC3 X-ray 2.26 E 321-464 [» ]
    ProteinModelPortali Q8NW39.
    SMRi Q8NW39. Positions 86-229, 326-467, 542-657.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196620.MW1674.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB95538 ; BAB95538 ; BAB95538 .
    GeneIDi 1003785.
    KEGGi sam:MW1674.
    PATRICi 19569962. VBIStaAur44266_1742.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000280077.
    OMAi VQTGQED.
    OrthoDBi EOG6RNQ8T.

    Enzyme and pathway databases

    BioCyci SAUR196620:GJ9Z-1696-MONOMER.

    Family and domain databases

    InterProi IPR019930. Haptoglobin-bd_HarA.
    IPR019931. LPXTG_anchor.
    IPR006635. NEAT_dom.
    IPR005877. YSIRK_signal_dom.
    [Graphical view ]
    Pfami PF05031. NEAT. 3 hits.
    PF04650. YSIRK_signal. 1 hit.
    [Graphical view ]
    SMARTi SM00725. NEAT. 3 hits.
    [Graphical view ]
    TIGRFAMsi TIGR03658. IsdH_HarA. 1 hit.
    TIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEi PS50978. NEAT. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MW2.

    Entry informationi

    Entry nameiISDH_STAAW
    AccessioniPrimary (citable) accession number: Q8NW39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3