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Protein

Iron-regulated surface determinant protein H

Gene

isdH

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-regulated surface determinant protein H
Alternative name(s):
Haptoglobin receptor A
Staphylococcus aureus surface protein I
Gene namesi
Name:isdH
Synonyms:harA, sasI
Ordered Locus Names:MW1674
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 40Sequence analysisAdd BLAST40
ChainiPRO_000028518941 – 864Iron-regulated surface determinant protein HAdd BLAST824
PropeptideiPRO_0000285190865 – 895Removed by sortaseSequence analysisAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei864Pentaglycyl murein peptidoglycan amidated threonineSequence analysis1

Keywords - PTMi

Peptidoglycan-anchor

Structurei

Secondary structure

1895
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi90 – 93Combined sources4
Helixi97 – 99Combined sources3
Beta strandi109 – 112Combined sources4
Beta strandi114 – 117Combined sources4
Helixi125 – 130Combined sources6
Beta strandi133 – 138Combined sources6
Beta strandi144 – 151Combined sources8
Turni153 – 155Combined sources3
Beta strandi156 – 167Combined sources12
Beta strandi171 – 175Combined sources5
Turni178 – 180Combined sources3
Beta strandi183 – 189Combined sources7
Beta strandi195 – 204Combined sources10
Beta strandi209 – 212Combined sources4
Beta strandi216 – 221Combined sources6
Turni326 – 328Combined sources3
Helixi330 – 333Combined sources4
Turni337 – 339Combined sources3
Beta strandi347 – 352Combined sources6
Beta strandi354 – 357Combined sources4
Beta strandi361 – 363Combined sources3
Helixi365 – 369Combined sources5
Beta strandi373 – 380Combined sources8
Beta strandi383 – 392Combined sources10
Turni393 – 395Combined sources3
Beta strandi396 – 403Combined sources8
Beta strandi411 – 416Combined sources6
Turni417 – 420Combined sources4
Beta strandi421 – 427Combined sources7
Beta strandi434 – 443Combined sources10
Turni444 – 446Combined sources3
Beta strandi447 – 460Combined sources14
Helixi472 – 486Combined sources15
Helixi490 – 503Combined sources14
Helixi506 – 529Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LHRNMR-A467-543[»]
3SZKX-ray3.01C/F86-229[»]
4FC3X-ray2.26E321-464[»]
ProteinModelPortaliQ8NW39.
SMRiQ8NW39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 232NEAT 1PROSITE-ProRule annotationAdd BLAST128
Domaini345 – 471NEAT 2PROSITE-ProRule annotationAdd BLAST127
Domaini543 – 660NEAT 3PROSITE-ProRule annotationAdd BLAST118

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi861 – 865LPXTG sorting signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi698 – 779Asp-richAdd BLAST82

Domaini

The NEAT 1 domain binds with higher affinity than the NEAT 2 domain haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin.By similarity

Sequence similaritiesi

Belongs to the IsdH family.Curated
Contains 3 NEAT domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000280077.
OMAiVQTGQED.

Family and domain databases

CDDicd06920. NEAT. 1 hit.
InterProiIPR019930. Haptoglobin-bd_HarA.
IPR006635. NEAT_dom.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF05031. NEAT. 3 hits.
[Graphical view]
SMARTiSM00725. NEAT. 3 hits.
[Graphical view]
TIGRFAMsiTIGR03658. IsdH_HarA. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50978. NEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NW39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKHHPKLRS FYSIRKSILG VASVIVSTLF LITSQHQAQA AENTNTSDKI
60 70 80 90 100
SENQNNNATT TQPPKDTNQT QPATQPANTA KTYPAADESL KDAIKDPALE
110 120 130 140 150
NKEHDIGPRE QVNFQLLDKN NETQYYHFFS IKDPADVYYT KKKAEVELDI
160 170 180 190 200
NTASTWKKFE VYENNQKLPV RLVSYSPVPE DHAYIRFPVS DGTQELKIVS
210 220 230 240 250
STQIDDGEET NYDYTKLVFA KPIYNDPSLV KSDTNDAVVT NDQSSSDASN
260 270 280 290 300
QTNTNTSNQN TSTINNANNQ PQATTNMSQP AQPKSSANAD QASSQPAHET
310 320 330 340 350
NSNGNTNDKT NESSNQSDVN QQYPPADESL QDAIKNPAII DKEHTADNWR
360 370 380 390 400
PIDFQMKNDK GERQFYHYAS TVEPATVIFT KTGPIIELGL KTASTWKKFE
410 420 430 440 450
VYEGDKKLPV ELVSYDSDKD YAYIRFPVSN GTREVKIVSS IEYGENIHED
460 470 480 490 500
YDYTLMVFAQ PITNNPDDYV DEETYNLQKL LAPYHKAKTL ERQVYELEKL
510 520 530 540 550
QEKLPEKYKA EYKKKLDQTR VELADQVKSA VTEFENVTPT NDQLTDVQEA
560 570 580 590 600
HFVVFESEEN SESVMDGFVE HPFYTATLNG QKYVVMKTKD DSYWKDLIVE
610 620 630 640 650
GKRVTTVSKD PKNNSRTLIF PYIPDKAVYN AIVKVVVANI GYEGQYHVRI
660 670 680 690 700
INQDINTKDD DTSQNNTSEP LNVQTGQEGK VADTDVAENS STATNPKDAS
710 720 730 740 750
DKADVIEPDS DVVKDADNNI DKDVQHDVDH LSDMSDNNHF DKYDLKEMDT
760 770 780 790 800
QIAKDTDRNV DKGADNSVGM SSNVDTDKDS NKNKDKVIQL NHIADKNNHN
810 820 830 840 850
GKAAKLDVVK QNYNNTDKVT DKKTTEHLPS DIHKTVDKTV KTKEKAGTPS
860 870 880 890
KENKLSQSKM LPKTGETTSS QSWWGLYALL GMLALFIPKF RKESK
Length:895
Mass (Da):100,847
Last modified:October 1, 2002 - v1
Checksum:i797BB0D67F9A0559
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95538.1.
RefSeqiWP_001032759.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95538; BAB95538; BAB95538.
KEGGisam:MW1674.
PATRICi19569962. VBIStaAur44266_1742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95538.1.
RefSeqiWP_001032759.1. NC_003923.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LHRNMR-A467-543[»]
3SZKX-ray3.01C/F86-229[»]
4FC3X-ray2.26E321-464[»]
ProteinModelPortaliQ8NW39.
SMRiQ8NW39.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB95538; BAB95538; BAB95538.
KEGGisam:MW1674.
PATRICi19569962. VBIStaAur44266_1742.

Phylogenomic databases

HOGENOMiHOG000280077.
OMAiVQTGQED.

Family and domain databases

CDDicd06920. NEAT. 1 hit.
InterProiIPR019930. Haptoglobin-bd_HarA.
IPR006635. NEAT_dom.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF05031. NEAT. 3 hits.
[Graphical view]
SMARTiSM00725. NEAT. 3 hits.
[Graphical view]
TIGRFAMsiTIGR03658. IsdH_HarA. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50978. NEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISDH_STAAW
AccessioniPrimary (citable) accession number: Q8NW39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.