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Q8NW39 (ISDH_STAAW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Iron-regulated surface determinant protein H
Alternative name(s):
Haptoglobin receptor A
Staphylococcus aureus surface protein I
Gene names
Name:isdH
Synonyms:harA, sasI
Ordered Locus Names:MW1674
OrganismStaphylococcus aureus (strain MW2) [Complete proteome] [HAMAP]
Taxonomic identifier196620 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length895 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone By similarity.

Subcellular location

Secretedcell wall; Peptidoglycan-anchor Potential.

Domain

The NEAT 1 domain binds with higher affinity than the NEAT 2 domain haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin By similarity.

Sequence similarities

Belongs to the IsdH family.

Contains 3 NEAT domains.

Ontologies

Keywords
   Cellular componentCell wall
Secreted
   DomainRepeat
Signal
   PTMPeptidoglycan-anchor
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Cellular_componentcell wall

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4040 Potential
Chain41 – 864824Iron-regulated surface determinant protein H
PRO_0000285189
Propeptide865 – 89531Removed by sortase Potential
PRO_0000285190

Regions

Domain105 – 232128NEAT 1
Domain345 – 471127NEAT 2
Domain543 – 660118NEAT 3
Motif861 – 8655LPXTG sorting signal Potential
Compositional bias698 – 77982Asp-rich

Amino acid modifications

Modified residue8641Pentaglycyl murein peptidoglycan amidated threonine Potential

Secondary structure

................................................................ 895
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8NW39 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 797BB0D67F9A0559

FASTA895100,847
        10         20         30         40         50         60 
MNKHHPKLRS FYSIRKSILG VASVIVSTLF LITSQHQAQA AENTNTSDKI SENQNNNATT 

        70         80         90        100        110        120 
TQPPKDTNQT QPATQPANTA KTYPAADESL KDAIKDPALE NKEHDIGPRE QVNFQLLDKN 

       130        140        150        160        170        180 
NETQYYHFFS IKDPADVYYT KKKAEVELDI NTASTWKKFE VYENNQKLPV RLVSYSPVPE 

       190        200        210        220        230        240 
DHAYIRFPVS DGTQELKIVS STQIDDGEET NYDYTKLVFA KPIYNDPSLV KSDTNDAVVT 

       250        260        270        280        290        300 
NDQSSSDASN QTNTNTSNQN TSTINNANNQ PQATTNMSQP AQPKSSANAD QASSQPAHET 

       310        320        330        340        350        360 
NSNGNTNDKT NESSNQSDVN QQYPPADESL QDAIKNPAII DKEHTADNWR PIDFQMKNDK 

       370        380        390        400        410        420 
GERQFYHYAS TVEPATVIFT KTGPIIELGL KTASTWKKFE VYEGDKKLPV ELVSYDSDKD 

       430        440        450        460        470        480 
YAYIRFPVSN GTREVKIVSS IEYGENIHED YDYTLMVFAQ PITNNPDDYV DEETYNLQKL 

       490        500        510        520        530        540 
LAPYHKAKTL ERQVYELEKL QEKLPEKYKA EYKKKLDQTR VELADQVKSA VTEFENVTPT 

       550        560        570        580        590        600 
NDQLTDVQEA HFVVFESEEN SESVMDGFVE HPFYTATLNG QKYVVMKTKD DSYWKDLIVE 

       610        620        630        640        650        660 
GKRVTTVSKD PKNNSRTLIF PYIPDKAVYN AIVKVVVANI GYEGQYHVRI INQDINTKDD 

       670        680        690        700        710        720 
DTSQNNTSEP LNVQTGQEGK VADTDVAENS STATNPKDAS DKADVIEPDS DVVKDADNNI 

       730        740        750        760        770        780 
DKDVQHDVDH LSDMSDNNHF DKYDLKEMDT QIAKDTDRNV DKGADNSVGM SSNVDTDKDS 

       790        800        810        820        830        840 
NKNKDKVIQL NHIADKNNHN GKAAKLDVVK QNYNNTDKVT DKKTTEHLPS DIHKTVDKTV 

       850        860        870        880        890 
KTKEKAGTPS KENKLSQSKM LPKTGETTSS QSWWGLYALL GMLALFIPKF RKESK 

« Hide

References

[1]"Genome and virulence determinants of high virulence community-acquired MRSA."
Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.
Lancet 359:1819-1827(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MW2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000033 Genomic DNA. Translation: BAB95538.1.
RefSeqNP_646490.1. NC_003923.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2LHRNMR-A467-543[»]
3SZKX-ray3.01C/F86-229[»]
4FC3X-ray2.26E321-464[»]
ProteinModelPortalQ8NW39.
SMRQ8NW39. Positions 86-229, 326-467, 542-657.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196620.MW1674.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB95538; BAB95538; BAB95538.
GeneID1003785.
KEGGsam:MW1674.
PATRIC19569962. VBIStaAur44266_1742.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000280077.
OMAVQTGQED.
OrthoDBEOG6RNQ8T.
ProtClustDBCLSK885152.

Enzyme and pathway databases

BioCycSAUR196620:GJ9Z-1696-MONOMER.

Family and domain databases

InterProIPR005877. Gpos_YSIRK.
IPR019930. Haptoglobin-bd_HarA.
IPR019931. LPXTG_anchor.
IPR006635. NEA_transpt.
[Graphical view]
PfamPF05031. NEAT. 3 hits.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SMARTSM00725. NEAT. 3 hits.
[Graphical view]
TIGRFAMsTIGR03658. IsdH_HarA. 1 hit.
TIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEPS50978. NEAT. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISDH_STAAW
AccessionPrimary (citable) accession number: Q8NW39
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references