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Q8NW17

- SYL_STAAW

UniProt

Q8NW17 - SYL_STAAW

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei582 – 5821ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-1724-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MW1701
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Leucine--tRNA ligasePRO_0000152087Add
BLAST

Proteomic databases

PRIDEiQ8NW17.

Interactioni

Protein-protein interaction databases

STRINGi196620.MW1701.

Structurei

3D structure databases

ProteinModelPortaliQ8NW17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionAdd
BLAST
Motifi579 – 5835"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NW17-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNYNHNQIE KKWQDYWDEN KTFKTNDNLG QKKFYALDMF PYPSGAGLHV
60 70 80 90 100
GHPEGYTATD IISRYKRMQG YNVLHPMGWD AFGLPAEQYA LDTGNDPREF
110 120 130 140 150
TKKNIQTFKR QIKELGFSYD WDREVNTTDP EYYKWTQWIF IQLYNKGLAY
160 170 180 190 200
VDEVAVNWCP ALGTVLSNEE VIDGVSERGG HPVYRKPMKQ WVLKITEYAD
210 220 230 240 250
QLLADLDDLD WPESLKDMQR NWIGRSEGAK VSFDVDNTEA EGKVEVFTTR
260 270 280 290 300
PDTIYGASFL VLSPEHALVN SITTDEYKEK VKAYQTEASK KSDLERTDLA
310 320 330 340 350
KDKSGVFTGA YAINPLSGEK VQIWIADYVL STYGTGAIMA VPAHDDRDYE
360 370 380 390 400
FAKKFDLPII EVIEGGNVEE AAYTGEGKHI NSGELDGLEN EAAITKAIQL
410 420 430 440 450
LEQKGAGEKK VNYKLRDWLF SRQRYWGEPI PVIHWEDGTM TTVPEEELPL
460 470 480 490 500
LLPETDEIKP SGTGESPLAN IDSFVNVVDE KTGMKGRRET NTMPQWAGSC
510 520 530 540 550
WYYLRYIDPK NENMLADPEK LKHWLPVDLY IGGVEHAVLH LLYARFWHKV
560 570 580 590 600
LYDLGIVPTK EPFQKLFNQG MILGEGNEKM SKSKGNVINP DDIVQSHGAD
610 620 630 640 650
TLRLYEMFMG PLDAAIAWSE KGLDGSRRFL DRVWRLMVNE DGTLSSKIVT
660 670 680 690 700
TNNKSLDKVY NQTVKKVTED FETLGFNTAI SQLMVFINEC YKVDEVYKPY
710 720 730 740 750
IEGFVKMLAP IAPHIGEELW SKLGHEESIT YQPWPTYDEA LLVDDEVEIV
760 770 780 790 800
VQVNGKLRAK IKIAKDTSKE EMQEIALSND NVKASIEGKD IMKVIAVPQK

LVNIVAK
Length:807
Mass (Da):91,984
Last modified:October 1, 2002 - v1
Checksum:i0E1E28BB1695AEC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB95566.1.
RefSeqiNP_646518.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95566; BAB95566; BAB95566.
GeneIDi1003813.
KEGGisam:MW1701.
PATRICi19570018. VBIStaAur44266_1770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB95566.1 .
RefSeqi NP_646518.1. NC_003923.1.

3D structure databases

ProteinModelPortali Q8NW17.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196620.MW1701.

Proteomic databases

PRIDEi Q8NW17.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB95566 ; BAB95566 ; BAB95566 .
GeneIDi 1003813.
KEGGi sam:MW1701.
PATRICi 19570018. VBIStaAur44266_1770.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SAUR196620:GJ9Z-1724-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiSYL_STAAW
AccessioniPrimary (citable) accession number: Q8NW17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3