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Q8NVH3

- THID_STAAW

UniProt

Q8NVH3 - THID_STAAW

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Protein

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene
thiD, MW2016
Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P By similarity.

Catalytic activityi

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451Substrate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydroxymethylpyrimidine kinase activity Source: UniProtKB-EC
  3. phosphomethylpyrimidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-2085-MONOMER.
UniPathwayiUPA00060; UER00137.
UPA00060; UER00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC:2.7.1.49, EC:2.7.4.7)
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name:
HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name:
HMP-P kinase
Short name:
HMP-phosphate kinase
Short name:
HMPP kinase
Gene namesi
Name:thiD
Ordered Locus Names:MW2016
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Hydroxymethylpyrimidine/phosphomethylpyrimidine kinasePRO_0000192032Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196620.MW2016.

Structurei

3D structure databases

ProteinModelPortaliQ8NVH3.

Family & Domainsi

Sequence similaritiesi

Belongs to the ThiD family.

Phylogenomic databases

eggNOGiCOG0351.
HOGENOMiHOG000225273.
KOiK00941.
OMAiYAPKNIV.
OrthoDBiEOG6XWV53.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NVH3-1 [UniParc]FASTAAdd to Basket

« Hide

MIKPKIALTI AGTDPTGGAG VMADLKSFHS CGVYGMGVVT SIVAQNTLGV    50
QHIHNLNHQW VDEQLDSVFN DTLPHAIKTG MIATADTMET IRHYLMQHES 100
IPYVIDPVML AKSGDSLMDN DTKQNLQHTL LPLADVVTPN LPEAEEITGL 150
TIDSEEKIMQ AGRIFINEIG SKGVIIKGGH SNDTDIAKDY LFTNEGVQTF 200
ENERFKTKHT HGTGCTFSAV ITAELAKGRR LFEAVHKAKK FISMSIQYTP 250
EIGRGRGPVN HFAYLKKEGL DDELSK 276
Length:276
Mass (Da):30,288
Last modified:October 1, 2002 - v1
Checksum:i42B2E36C97F1310D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB95881.1.
RefSeqiNP_646833.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95881; BAB95881; BAB95881.
GeneIDi1004132.
KEGGisam:MW2016.
PATRICi19570748. VBIStaAur44266_2092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB95881.1 .
RefSeqi NP_646833.1. NC_003923.1.

3D structure databases

ProteinModelPortali Q8NVH3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196620.MW2016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB95881 ; BAB95881 ; BAB95881 .
GeneIDi 1004132.
KEGGi sam:MW2016.
PATRICi 19570748. VBIStaAur44266_2092.

Phylogenomic databases

eggNOGi COG0351.
HOGENOMi HOG000225273.
KOi K00941.
OMAi YAPKNIV.
OrthoDBi EOG6XWV53.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00137 .
UPA00060 ; UER00138 .
BioCyci SAUR196620:GJ9Z-2085-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
InterProi IPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF08543. Phos_pyr_kin. 1 hit.
[Graphical view ]
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiTHID_STAAW
AccessioniPrimary (citable) accession number: Q8NVH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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