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Protein

Putative aldehyde dehydrogenase MW2046

Gene

MW2046

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei245 – 2451By similarity
Active sitei279 – 2791By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi201 – 2077NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-2115-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aldehyde dehydrogenase MW2046 (EC:1.2.1.3)
Gene namesi
Ordered Locus Names:MW2046
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Putative aldehyde dehydrogenase MW2046PRO_0000293557Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8NVG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00128.
OMAiEMPNKFQ.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NVG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDYTKQYIN GEWVESNSNE TIEVINPATE EVIGKVAKGN KADVDKAVEA
60 70 80 90 100
ADNVYLEFRH TSVKERQALL DKIVKEYENR KDDIVQAITD ELGAPLSLSE
110 120 130 140 150
RVHYQMGLNH FVAARDALDN YEFEERRGDD LVVKEAIGVS GLITPWNFPT
160 170 180 190 200
NQTSLKLAAA FAAGSPVVLK PSEETPFAAV ILAEIFDKVG VPKGVFNLVN
210 220 230 240 250
GDGAGVGNPL SEHPKVRMMS FTGSGPTGSK IMEKAAKDFK KVSLELGGKS
260 270 280 290 300
PYIVLDDVDI KEAAKATTGK VVNNTGQVCT AGTRVLVPKK IKDAFLAELK
310 320 330 340 350
EQFSQVRVGN PREDGTQVGP IISKKQFDQV QNYINKGIEE GAELFYGGPG
360 370 380 390 400
KPEGLEKGYF ARPTIFINVD NQMTIAQEEI FGPVMSVITY NDLDEAIQIA
410 420 430 440 450
NDTKYGLAGY VIGKDKETLH KVARSIEAGT VEINEAGRKP DLPFGGYKQS
460 470
GLGREWGDYG IEEFLEVKSI AGYFK
Length:475
Mass (Da):51,982
Last modified:October 1, 2002 - v1
Checksum:i6D8F555E7F35D4C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95911.1.
RefSeqiWP_001206105.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95911; BAB95911; BAB95911.
KEGGisam:MW2046.
PATRICi19570806. VBIStaAur44266_2121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95911.1.
RefSeqiWP_001206105.1. NC_003923.1.

3D structure databases

ProteinModelPortaliQ8NVG4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB95911; BAB95911; BAB95911.
KEGGisam:MW2046.
PATRICi19570806. VBIStaAur44266_2121.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00128.
OMAiEMPNKFQ.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-2115-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiALD1_STAAW
AccessioniPrimary (citable) accession number: Q8NVG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.