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Protein

Type II pantothenate kinase

Gene

coaW

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type II pantothenate kinase (coaW)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei70 – 701Proton acceptorUniRule annotation
Binding sitei99 – 991ATPUniRule annotation
Binding sitei137 – 1371ATPUniRule annotation
Binding sitei225 – 2251ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 138ATPUniRule annotation
Nucleotide bindingi121 – 1255ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-2123-MONOMER.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Type II pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaWUniRule annotation
Ordered Locus Names:MW2054
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Type II pantothenate kinasePRO_0000261348Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

Secondary structure

1
267
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 76Combined sources
Beta strandi9 – 179Combined sources
Beta strandi22 – 287Combined sources
Helixi29 – 313Combined sources
Helixi32 – 409Combined sources
Beta strandi47 – 515Combined sources
Helixi54 – 596Combined sources
Beta strandi61 – 633Combined sources
Beta strandi65 – 673Combined sources
Helixi70 – 8415Combined sources
Beta strandi92 – 10615Combined sources
Beta strandi111 – 1188Combined sources
Helixi121 – 13212Combined sources
Helixi137 – 1448Combined sources
Turni150 – 1523Combined sources
Helixi156 – 1605Combined sources
Beta strandi171 – 1744Combined sources
Turni175 – 1784Combined sources
Helixi179 – 1813Combined sources
Helixi189 – 21527Combined sources
Beta strandi219 – 2246Combined sources
Helixi225 – 2273Combined sources
Helixi231 – 24313Combined sources
Beta strandi247 – 2504Combined sources
Helixi254 – 2563Combined sources
Helixi257 – 26711Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4M7XX-ray1.42A1-267[»]
4M7YX-ray1.80A/B1-267[»]
ProteinModelPortaliQ8NVG0.
SMRiQ8NVG0. Positions 1-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II pantothenate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000092412.
OMAiKVKHIYK.
OrthoDBiEOG61S33B.

Family and domain databases

HAMAPiMF_01273. Pantothen_kinase_2.
InterProiIPR004567. Type_II_PanK.
IPR011602. Type_II_PanK_bac.
[Graphical view]
PfamiPF03630. Fumble. 1 hit.
[Graphical view]
PIRSFiPIRSF036940. PanK_bac_aCoA. 1 hit.
TIGRFAMsiTIGR00555. panK_eukar. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NVG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVGIDAGGT LIKIVQEQDN QRTFKTELTK NIDQVVEWLN QQQIEKLCLT
60 70 80 90 100
GGNAGVIAEN INIPAQIFVE FDAASQGLGI LLKEQGHDLA DYIFANVGTG
110 120 130 140 150
TSLHYFDGQS QRRVGGIGTG GGMIQGLGYL LSQITDYKQL TDMAQHGDRN
160 170 180 190 200
TIDLKVRHIY KDTEPPIPGD LTAANFGHVL HHLDADFTPS NKLAAVIGVV
210 220 230 240 250
GEVVTTMAIT VAREFKTENI VYIGSSFHNN ALLRKVVEDY TVLRGCKPYY
260
VENGAFSGAI GALYLEK
Length:267
Mass (Da):29,097
Last modified:October 1, 2002 - v1
Checksum:i3663BBC6DFBC2D9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95919.1.
RefSeqiWP_000862727.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95919; BAB95919; BAB95919.
PATRICi19570822. VBIStaAur44266_2129.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95919.1.
RefSeqiWP_000862727.1. NC_003923.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4M7XX-ray1.42A1-267[»]
4M7YX-ray1.80A/B1-267[»]
ProteinModelPortaliQ8NVG0.
SMRiQ8NVG0. Positions 1-267.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi1004170.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB95919; BAB95919; BAB95919.
PATRICi19570822. VBIStaAur44266_2129.

Phylogenomic databases

HOGENOMiHOG000092412.
OMAiKVKHIYK.
OrthoDBiEOG61S33B.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.
BioCyciSAUR196620:GJ9Z-2123-MONOMER.

Family and domain databases

HAMAPiMF_01273. Pantothen_kinase_2.
InterProiIPR004567. Type_II_PanK.
IPR011602. Type_II_PanK_bac.
[Graphical view]
PfamiPF03630. Fumble. 1 hit.
[Graphical view]
PIRSFiPIRSF036940. PanK_bac_aCoA. 1 hit.
TIGRFAMsiTIGR00555. panK_eukar. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiCOAW_STAAW
AccessioniPrimary (citable) accession number: Q8NVG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.