Q8NVE3 (ARGI_STAAW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginase
EC=3.5.3.1

Gene names

Name:	arg
Ordered Locus Names:	MW2091

Organism

Staphylococcus aureus (strain MW2) [Complete proteome] [HAMAP]

Taxonomic identifier

196620 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-arginine + H2O = L-ornithine + urea.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Pathway	Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
Sequence similarities	Belongs to the arginase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arginase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	Arginase		PRO_0000173724
Regions
	Region	128 – 132	5	Substrate binding By similarity
	Region	139 – 141	3	Substrate binding By similarity
Sites
	Metal binding	103	1	Manganese 1 By similarity
	Metal binding	126	1	Manganese 1 By similarity
	Metal binding	126	1	Manganese 2 By similarity
	Metal binding	128	1	Manganese 2 By similarity
	Metal binding	130	1	Manganese 1 By similarity
	Metal binding	229	1	Manganese 1 By similarity
	Metal binding	229	1	Manganese 2 By similarity
	Metal binding	231	1	Manganese 2 By similarity
	Binding site	180	1	Substrate By similarity
	Binding site	274	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8NVE3 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 1D983B4783BAC772	FASTA	302	33,293
	10 20 30 40 50 60 MTKTKAIDII GAPSTFGQRK LGVDLGPTAI RYAGLISRLK QLDLDVYDKG DIKVPVVNIE 70 80 90 100 110 120 KFHSEQKGLR NYDEIIDVNQ KLNKEVSASI ENNRFPLVLG GDHSIAVGSV SAISKHYNNL 130 140 150 160 170 180 GVIWYDAHGD LNIPEESPSG NIHGMPLRIL TGEGPKELLE LNSNVIKPEN IVLIGMRDLD 190 200 210 220 230 240 KGERQFIKDH NIKTFTMSDI DKLGIKEVIE NTIEYLKSRN VDGVHLSLDV DALDPLETPG 250 260 270 280 290 300 TGTRVLGGLS YRESHFALEL LHQSHLISSM DLVEVNPLID SNNHTAEQAV SLVGTFFGET LL

References

[1]	"Genome and virulence determinants of high virulence community-acquired MRSA." Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K. Lancet 359:1819-1827(2002) [PubMed: 12044378] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MW2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000033 Genomic DNA. Translation: BAB95956.1.
RefSeq	NP_646908.1. NC_003923.1.
3D structure databases
ProteinModelPortal	Q8NVE3.
SMR	Q8NVE3. Positions 5-302.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NVE3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000025315; EBSTAP00000024354; EBSTAG00000025314.
GeneID	1004206.
GenomeReviews	Gene locus MW2091 in contig BA000033_GR.
KEGG	sam:MW2091.
PATRIC	19570890. VBIStaAur44266_2163.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0010.
GeneTree	EBGT00050000025100.
HOGENOM	HBG391953.
OMA	ADIPNDS.
ProtClustDB	CLSK885803.
Enzyme and pathway databases
BioCyc	SAUR196620:MW2091-MONOMER.
Family and domain databases
InterPro	IPR014033. Arginase_subgr. IPR006035. Ureohydrolase. IPR023696. Ureohydrolase_domain. IPR020855. Ureohydrolase_Mn_BS. [Graphical view]
Gene3D	G3DSA:3.40.800.10. Ureohydrolase. 1 hit.
KO	K01476.
PANTHER	PTHR11358:SF2. Arginase_sub. 1 hit. PTHR11358. Ureohydrolase. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
PIRSF	PIRSF036979. Arginase. 1 hit.
PRINTS	PR00116. ARGINASE.
TIGRFAMs	TIGR01229. RocF_arginase. 1 hit.
PROSITE	PS01053. ARGINASE_1. 1 hit. PS51409. ARGINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGI_STAAW

Accession

Primary (citable) accession number: Q8NVE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program