ID   GTAB_STAAW              Reviewed;         288 AA.
AC   Q8NUU9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase;
DE            EC=2.7.7.9;
DE   AltName: Full=UDP-glucose pyrophosphorylase;
DE            Short=UDPGP;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase;
GN   Name=gtaB; OrderedLocusNames=MW2419;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22040717; PubMed=12044378; DOI=10.1016/S0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A.,
RA   Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L.,
RA   Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-
RT   acquired MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Catalyzes the formation of UDP-glucose from glucose-1-
CC       phosphate and UTP. This is an intermediate step in the
CC       biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the
CC       predominant glycolipid found in the S.aureus membrane, which is
CC       also used as a membrane anchor for lipoteichoic acid (LTA) (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: UTP + alpha-D-glucose 1-phosphate =
CC       diphosphate + UDP-glucose.
CC   -!- PATHWAY: Glycolipid metabolism; diglucosyl-diacylglycerol
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family.
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DR   EMBL; BA000033; BAB96284.1; -; Genomic_DNA.
DR   RefSeq; NP_647236.1; -.
DR   HSSP; P26393; 1IIN.
DR   GeneID; 1004555; -.
DR   GenomeReviews; BA000033_GR; MW2419.
DR   KEGG; sam:MW2419; -.
DR   HOGENOM; Q8NUU9; -.
DR   OMA; Q8NUU9; DINICFI.
DR   BioCyc; SAUR196620:MW2419-MON; -.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase...; IEA:EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   InterPro; IPR005771; GalU_trans_bac.
DR   InterPro; IPR005835; NTP_transferase.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   TIGRFAMs; TIGR01099; galU; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Nucleotidyltransferase;
KW   Transferase.
FT   CHAIN         1    288       UTP--glucose-1-phosphate
FT                                uridylyltransferase.
FT                                /FTId=PRO_0000308309.
SQ   SEQUENCE   288 AA;  32509 MW;  126BF003999D4418 CRC64;
     MKKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEAARAGI EDIIIVTGRH
     KRAIEDHFDS QKELEMVLKE KGKSELLEKV QYSTELANIF YVRQKEQKGL GHAISSARQF
     IGNEPFAVLL GDDIVESEVP AVKQLIDVYE ETGHSVIGVQ EVPEADTHRY GIIDPLTKNG
     RQYEVKKFVE KPAQGTAPSN LAIMGRYVLT PEIFDYLKTQ KEGAGNEIQL TDAIERMNND
     NQVYAYDFEG ERYDVGEKLG FVKTTIEYAL KDDSMREELT RFIKELGL
//