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Q8NUM5 (ALF1_STAAW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase class 1
EC=4.1.2.13
Alternative name(s):
Fructose-biphosphate aldolase class I
Short name=FBP aldolase
Gene names
Name:fda
Ordered Locus Names:MW2525
OrganismStaphylococcus aureus (strain MW2) [Complete proteome] [HAMAP]
Taxonomic identifier196620 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. HAMAP MF_00729

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. HAMAP MF_00729

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 296295Fructose-bisphosphate aldolase class 1 HAMAP MF_00729
PRO_0000216908

Sites

Active site1751Proton acceptor By similarity
Active site2121Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NUM5 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: C6D620FBD9F76E96

FASTA29632,967
        10         20         30         40         50         60 
MNKEQLEKMK NGKGFIAALD QSGGSTPKAL KEYGVNEDQY SNEDEMFQLV HDMRTRVVTS 

        70         80         90        100        110        120 
PSFSPDKILG AILFEQTMDR EVEGKYTADY LADKGVVPFL KVDKGLAEEQ NGVQLMKPID 

       130        140        150        160        170        180 
NLDSLLDRAN ERHIFGTKMR SNILELNEQG IKDVVEQQFE VAKQIIAKGL VPIIEPEVNI 

       190        200        210        220        230        240 
NAKDKAEIEK VLKAELKKGL DNLNADQLVM LKLTIPTEPN LYKELAEHPN VVRVVVLSGG 

       250        260        270        280        290 
YSREKANELL KDNAELIASF SRALASDLRA GQSKEEFDKA LGDAVESIYD ASVNKN

« Hide

References

[1]"Genome and virulence determinants of high virulence community-acquired MRSA."
Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.
Lancet 359:1819-1827(2002) [PubMed: 12044378] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MW2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000033 Genomic DNA. Translation: BAB96390.1.
RefSeqNP_647342.1. NC_003923.1.

3D structure databases

ProteinModelPortalQ8NUM5.
SMRQ8NUM5. Positions 1-294.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8NUM5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000026540; EBSTAP00000025579; EBSTAG00000026539.
GeneID1004661.
GenomeReviewsGene locus MW2525 in contig BA000033_GR.
KEGGsam:MW2525.
PATRIC19571796. VBIStaAur44266_2609.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3588.
GeneTreeEBGT00050000024908.
HOGENOMHBG307137.
OMAGTKMRSV.
ProtClustDBPRK05377.

Enzyme and pathway databases

BioCycSAUR196620:MW2525-MONOMER.

Family and domain databases

HAMAPMF_00729. FBP_aldolase_1.
[Tree]
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
IPR023014. FBP_aldolase_I_bac.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01623.
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEPS00158. ALDOLASE_CLASS_I. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF1_STAAW
AccessionPrimary (citable) accession number: Q8NUM5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 54 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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