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Q8NUM5

- ALF1_STAAW

UniProt

Q8NUM5 - ALF1_STAAW

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Protein
Fructose-bisphosphate aldolase class 1
Gene
fda, MW2525
Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei175 – 1751Proton acceptor By similarity
Active sitei212 – 2121Schiff-base intermediate with dihydroxyacetone-P By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-2601-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolase
Gene namesi
Name:fda
Ordered Locus Names:MW2525
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 296295Fructose-bisphosphate aldolase class 1UniRule annotation
PRO_0000216908Add
BLAST

Proteomic databases

PRIDEiQ8NUM5.

Interactioni

Protein-protein interaction databases

STRINGi196620.MW2525.

Structurei

3D structure databases

ProteinModelPortaliQ8NUM5.
SMRiQ8NUM5. Positions 1-294.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3588.
HOGENOMiHOG000073502.
KOiK01623.
OMAiAILFEAT.
OrthoDBiEOG6M6JJT.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00729. FBP_aldolase_1.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NUM5-1 [UniParc]FASTAAdd to Basket

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MNKEQLEKMK NGKGFIAALD QSGGSTPKAL KEYGVNEDQY SNEDEMFQLV    50
HDMRTRVVTS PSFSPDKILG AILFEQTMDR EVEGKYTADY LADKGVVPFL 100
KVDKGLAEEQ NGVQLMKPID NLDSLLDRAN ERHIFGTKMR SNILELNEQG 150
IKDVVEQQFE VAKQIIAKGL VPIIEPEVNI NAKDKAEIEK VLKAELKKGL 200
DNLNADQLVM LKLTIPTEPN LYKELAEHPN VVRVVVLSGG YSREKANELL 250
KDNAELIASF SRALASDLRA GQSKEEFDKA LGDAVESIYD ASVNKN 296
Length:296
Mass (Da):32,967
Last modified:January 23, 2007 - v3
Checksum:iC6D620FBD9F76E96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB96390.1.
RefSeqiNP_647342.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB96390; BAB96390; BAB96390.
GeneIDi1004661.
KEGGisam:MW2525.
PATRICi19571796. VBIStaAur44266_2609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB96390.1 .
RefSeqi NP_647342.1. NC_003923.1.

3D structure databases

ProteinModelPortali Q8NUM5.
SMRi Q8NUM5. Positions 1-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196620.MW2525.

Proteomic databases

PRIDEi Q8NUM5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB96390 ; BAB96390 ; BAB96390 .
GeneIDi 1004661.
KEGGi sam:MW2525.
PATRICi 19571796. VBIStaAur44266_2609.

Phylogenomic databases

eggNOGi COG3588.
HOGENOMi HOG000073502.
KOi K01623.
OMAi AILFEAT.
OrthoDBi EOG6M6JJT.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci SAUR196620:GJ9Z-2601-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00729. FBP_aldolase_1.
InterProi IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view ]
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiALF1_STAAW
AccessioniPrimary (citable) accession number: Q8NUM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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