Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q8NUK8 (OTCC_STAAW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3
Gene names
Name:arcB
Ordered Locus Names:MW2555
OrganismStaphylococcus aureus (strain MW2) [Complete proteome] [HAMAP]
Taxonomic identifier196620 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109

Subcellular location

Cytoplasm Probable HAMAP MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processArginine metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 336336Ornithine carbamoyltransferase, catabolic HAMAP MF_01109
PRO_0000113020

Regions

Region62 – 665Carbamoyl phosphate binding By similarity
Region276 – 2794Ornithine binding By similarity

Sites

Binding site1131Carbamoyl phosphate By similarity
Binding site1401Carbamoyl phosphate By similarity
Site371Important for structural integrity By similarity
Site1531Important for structural integrity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NUK8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: F87470583F496AFC

FASTA33637,763
        10         20         30         40         50         60 
MTEIQKPYDL KGRSLLKESD FTKAEFEGLI DFAITLKEYK KNGIKHHYLS GKNIALLFEK 

        70         80         90        100        110        120 
NSTRTRAAFT VASIDLGAHP EFLGKNDIQL GKKESVEDTA KVLGRMFDGI EFRGFSQQAV 

       130        140        150        160        170        180 
EDLAKFSGVP VWNGLTDDWH PTQMLADFMT IKENFGYLEG INLTYVGDGR NNIAHSLMVA 

       190        200        210        220        230        240 
GAMLGVNVRI CTPKSLNPKE AYVDIAKEKA SQYGGSVMIT DNIAEAVENT DAIYTDVWVS 

       250        260        270        280        290        300 
MGEESEFEQR INLLKDYQVN QQMFDLTGKD STIFLHCLPA FHDTNTLYGQ EIYEKYGLAE 

       310        320        330 
MEVTDQIFRS EHSKVFDQAE NRMHTIKAVM AATLGS

« Hide

References

[1]"Genome and virulence determinants of high virulence community-acquired MRSA."
Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.
Lancet 359:1819-1827(2002) [PubMed: 12044378] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MW2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000033 Genomic DNA. Translation: BAB96420.1.
RefSeqNP_647372.1. NC_003923.1.

3D structure databases

ProteinModelPortalQ8NUK8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8NUK8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000025335; EBSTAP00000024374; EBSTAG00000025334.
GeneID1004691.
GenomeReviewsGene locus MW2555 in contig BA000033_GR.
KEGGsam:MW2555.
PATRIC19571858. VBIStaAur44266_2640.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0078.
GeneTreeEBGT00050000023906.
HOGENOMHBG579429.
OMAVRICTPE.
ProtClustDBPRK02102.

Enzyme and pathway databases

BioCycSAUR196620:MW2555-MONOMER.

Family and domain databases

HAMAPMF_01109. OTCase.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
KOK00611.
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00658. Orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTCC_STAAW
AccessionPrimary (citable) accession number: Q8NUK8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents