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Protein

Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase

Gene

icaB

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. N-deacetylation is crucial for attachment of the polysaccharide to the bacterial cell surface; it leads to the introduction of positive charges in the otherwise neutral PIA polymer, allowing electrostatic interactions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase (EC:3.5.1.-)
Short name:
PNAG N-deacetylase
Short name:
Poly-beta-1,6-GlcNAc N-deacetylase
Alternative name(s):
Biofilm polysaccharide intercellular adhesin deacetylase
Short name:
Biofilm PIA deacetylase
Intercellular adhesion protein B
Gene namesi
Name:icaB
Ordered Locus Names:MW2588
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000002483929 – 290Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylaseAdd BLAST262

Structurei

3D structure databases

ProteinModelPortaliQ8NUI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 290NodB homologyPROSITE-ProRule annotationAdd BLAST177

Sequence similaritiesi

Belongs to the polysaccharide deacetylase family.Curated
Contains 1 NodB homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000280325.
OMAiLYHRFGP.

Family and domain databases

Gene3Di3.20.20.370. 1 hit.
InterProiIPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. NODB_dom.
IPR023872. PNAG_deacetylase.
[Graphical view]
PfamiPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 1 hit.
TIGRFAMsiTIGR03933. PIA_icaB. 1 hit.
PROSITEiPS51677. NODB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NUI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYRKFIILV LSILIILPVS TLDGHHIANA DDDSPKKLKY KENSALALNY
60 70 80 90 100
HRVRKANFLN NFIYFFSSSK EIKNYSVSQS QFESQIKWLK SHDAKFLTLK
110 120 130 140 150
EFLYYKKKGK FPKRSVWINF DDMDETIYEN AYPILKKYKI PATGFIITGH
160 170 180 190 200
VGEENFHNLD MISKKELKEM YKTGLWEFET HTHDLHNLSK NNKSKLMKAS
210 220 230 240 250
EATIIKDLNK SEKYLTKNFK KSQKTIAYPY GLMNDDKLPV IKKAGLKYGF
260 270 280 290
SLEEKAVTPN SNDYYIPRIL ISDDAFEHLI KRWDGFHEKD
Length:290
Mass (Da):34,105
Last modified:October 1, 2002 - v1
Checksum:i76D1B0DA47C726A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB96453.1.
RefSeqiWP_000877317.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB96453; BAB96453; BAB96453.
GeneIDi28379686.
KEGGisam:MW2588.
PATRICi19571926. VBIStaAur44266_2674.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB96453.1.
RefSeqiWP_000877317.1. NC_003923.1.

3D structure databases

ProteinModelPortaliQ8NUI6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB96453; BAB96453; BAB96453.
GeneIDi28379686.
KEGGisam:MW2588.
PATRICi19571926. VBIStaAur44266_2674.

Phylogenomic databases

HOGENOMiHOG000280325.
OMAiLYHRFGP.

Family and domain databases

Gene3Di3.20.20.370. 1 hit.
InterProiIPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. NODB_dom.
IPR023872. PNAG_deacetylase.
[Graphical view]
PfamiPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 1 hit.
TIGRFAMsiTIGR03933. PIA_icaB. 1 hit.
PROSITEiPS51677. NODB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiICAB_STAAW
AccessioniPrimary (citable) accession number: Q8NUI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.