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Q8NUI5 (LIP1_STAAW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lipase 1
EC=3.1.1.3
Alternative name(s):
Glycerol ester hydrolase 1
Gene names
Name:lip1
Ordered Locus Names:MW2590
OrganismStaphylococcus aureus (strain MW2) [Complete proteome] [HAMAP]
Taxonomic identifier196620 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length680 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Sequence caution

The sequence BAB96455.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processLipid degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMZymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular functiontriglyceride lipase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Propeptide35 – 290256 By similarity
PRO_0000045184
Chain291 – 680390Lipase 1
PRO_0000045185

Sites

Active site4081Charge relay system By similarity
Active site6391Charge relay system By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NUI5 [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: F91CD0F8648263E7

FASTA68076,675
        10         20         30         40         50         60 
MKSQNKYSIR KFSVGASSIL IATLLFLSGG QAQAAEKQVN MGNSQEDTVT AQSIGDQQTR 

        70         80         90        100        110        120 
ENANYQRENG VDEQQHTENL TKNLHNDKTI SEENHRKTDD LNKDQLKDDK KSSLNNKNIQ 

       130        140        150        160        170        180 
RDTTKNNNAN PSDVNQGLEQ AINDGKQSKV ASQQQSKEAD NSQDSNANNN LPSQSRIKEA 

       190        200        210        220        230        240 
PSLNKLDQTS QREIVNETEI EKVQPQQNNQ ANDKITNYNF NNEQEVKPQK DEKTLSVSDL 

       250        260        270        280        290        300 
KNNQKSPVEP TKDNDKKNGL NLLKSSAVAT LPNKGTKELT AKAKDDQTNK VAKQGQYKNQ 

       310        320        330        340        350        360 
DPIVLVHGFN GFTDDINPSV LAHYWGGNKM NIRQDLEENG YKAYEASISA FGSNYDRAVE 

       370        380        390        400        410        420 
LYYYIKGGRV DYGAAHAAKY GHERYGKTYE GIYKDWKPGQ KVHLVGHSMG GQTIRQLEEL 

       430        440        450        460        470        480 
LRNGNREEIE YQKKHGGEIS PLFKGNHDNM ISSITTLGTP HNGTHASDLA GNEALVRQIV 

       490        500        510        520        530        540 
FDIGKMFGNK NSRVDFGLAQ WGLKQKPNES YIDYVKRVKQ SNLWKSKDNG FYDLTREGAT 

       550        560        570        580        590        600 
DLNRKTSLNP NIVYKTYTGE ATHKALNSDR QKADLNMFFP FVITGNLIGK ATEKEWREND 

       610        620        630        640        650        660 
GLVSVISSQH PFNQAYTKAT DKIQKGIWQV TPTKHDWDHV DFVGQDSSDT VRTREELQDF 

       670        680 
WHHLADDLVK TEKLTDTKQA

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References

[1]"Genome and virulence determinants of high virulence community-acquired MRSA."
Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.
Lancet 359:1819-1827(2002) [PubMed: 12044378] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MW2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000033 Genomic DNA. Translation: BAB96455.1. Different initiation.
RefSeqNP_647407.1. NC_003923.1.

3D structure databases

ProteinModelPortalQ8NUI5.
SMRQ8NUI5. Positions 297-677.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8NUI5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000025729; EBSTAP00000024768; EBSTAG00000025728.
GeneID1004726.
GenomeReviewsGene locus MW2590 in contig BA000033_GR.
KEGGsam:MW2590.
PATRIC19571932. VBIStaAur44266_2677.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1075.
GeneTreeEBGT00050000023709.
HOGENOMHBG694146.
OMAYTGESTH.
ProtClustDBCLSK2752181.

Enzyme and pathway databases

BioCycSAUR196620:MW2590-MONOMER.

Family and domain databases

InterProIPR005877. Gpos_YSIRK.
[Graphical view]
KOK01046.
PfamPF04650. YSIRK_signal. 1 hit.
[Graphical view]
TIGRFAMsTIGR01168. YSIRK_signal. 1 hit.
PROSITEPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLIP1_STAAW
AccessionPrimary (citable) accession number: Q8NUI5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: January 25, 2012
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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