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Q8NUC6 (Q8NUC6_CORGL) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897
Gene names
Name:gyrA HAMAP MF_01897 EMBL CAF18578.1
Ordered Locus Names:cg0015, Cgl0013
OrganismCorynebacterium glutamicum (Brevibacterium flavum)
Taxonomic identifier1718 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length856 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897

Subcellular location

Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q8NUC6 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 3AABFBF4AE9C52AB

FASTA85694,803
        10         20         30         40         50         60 
MSDDNTGQFD RVNPIDINEE MQSSYIDYAM SVIVGRALPE VRDGLKPVHR RVLYAMFDNG 

        70         80         90        100        110        120 
YRPDRSYVKS AKPVADTMGN FHPHGDTAIY DTLVRMAQPW SMRYPLVDGQ GNFGSRGNDG 

       130        140        150        160        170        180 
PAAMRYTECR MTPLAMEMVR DIRENTVNFS PNYDGKTLEP DVLPSRVPNL LMNGSGGIAV 

       190        200        210        220        230        240 
GMATNIPPHN LNELADAIFW LLENPDAEES EALEACMKFV KGPDFPTAGL IIGDKGIHDA 

       250        260        270        280        290        300 
YTTGRGSIRM RGVTSIEEEG NRTVIVITEL PYQVNPDNLI SNIAEQVRDG KLVGISKIED 

       310        320        330        340        350        360 
ESSDRVGMRI VVTLKRDAVA RVVLNNLFKH SQLQANFGAN MLSIVDGVPR TLRLDQMLRY 

       370        380        390        400        410        420 
YVAHQIEVIV RRTQYRLDKA EERAHLLRGL VKALDMLDEV IALIRRSPTP DEARTGLMSL 

       430        440        450        460        470        480 
LDVDEAQADA ILAMQLRRLA ALERQKIIDE LAEIELEIAD LKAILASPER QRTIVRDELT 

       490        500        510        520        530        540 
EIVEKYGDER RSQIIAATGD VSEEDLIARE NVVITITSTG YAKRTKVDAY KSQKRGGKGV 

       550        560        570        580        590        600 
RGAELKQDDI VRHFFVSSTH DWILFFTNYG RVYRLKAFEL PEASRTARGQ HVANLLEFQP 

       610        620        630        640        650        660 
GEQIAQVIQL ESYNDFPYLV LATAHGRVKK SRLLDYESAR SGGLIAINLN EDDRLIGAAL 

       670        680        690        700        710        720 
CGEEDDLLLV SEFGQSIRFT ADDEQLRPMG RATAGVKGMR FRDNDQLLSM SVVRDGEFLL 

       730        740        750        760        770        780 
VATSGGYGKR TPLEDYSTQG RGGLGVVTFK YTPKRGRLVS AIAVEEDDEI FAITSAGGVV 

       790        800        810        820        830        840 
RTEVKQIRPS SRATMGVRLV NLEEGVELLA IDKNVEDQGE ASAEAVAKGA VEGPASKTAA 

       850 
EETDSVDNGS DENGEE

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References

[1]"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins."
Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. expand/collapse author list , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.
J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025 [Kalinowski].
[2]"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032."
Nakagawa S.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025 [Nakagawa].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000036 Genomic DNA. Translation: BAB97406.1.
BX927148 Genomic DNA. Translation: CAF18578.1.
RefSeqNP_599264.1. NC_003450.3.
YP_224307.1. NC_006958.1.

3D structure databases

HSSPHSSP built from PDB template 1AB4 based on UniProtKB P09097.
ProteinModelPortalQ8NUC6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1021254.
3343245.
GenomeReviewsGene locus Cgl0013 in contig BA000036_GR.
Gene locus cg0015 in contig BX927147_GR.
KEGGcgb:cg0015.
cgl:NCgl0012.
PATRIC21492048. VBICorGlu203724_0012.

Phylogenomic databases

HOGENOMHBG635183.
OMATGRGRIY.
PhylomeDBQ8NUC6.
ProtClustDBPRK05560.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ8NUC6_CORGL
AccessionPrimary (citable) accession number: Q8NUC6
Secondary accession number(s): Q6M8W9
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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