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Q8NU97

- PKN2_CORGL

UniProt

Q8NU97 - PKN2_CORGL

Protein

Serine/threonine-protein kinases PknA

Gene

pknA

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491ATPPROSITE-ProRule annotation
    Active sitei148 – 1481Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: CACAO
    3. transferase activity, transferring phosphorus-containing groups Source: CACAO

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinases PknA (EC:2.7.11.1)
    Gene namesi
    Name:pknA
    Synonyms:drp72
    Ordered Locus Names:Cgl0042, cg0059
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469Serine/threonine-protein kinases PknAPRO_0000171199Add
    BLAST

    PTM databases

    PhosSiteiP0904601.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-48320N.
    STRINGi196627.cg0059.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NU97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 281262Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi354 – 44087Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000037187.
    KOiK08884.
    OMAiHGGMSTV.
    OrthoDBiEOG6B35XT.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NU97-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQEDITGKD RLQELIGADY RLQWIIGHGG MSTVWLADDV VNDREVAIKV    50
    LRPEFSDNQE FLNRFRNEAQ AAENIDSEHV VATYDYREVP DPAGHTFCFI 100
    VMEFVRGESL ADLLEREGRL PEDLALDVME QAAHGLSVIH RMDMVHRDIK 150
    PGNMLITANG IVKITDFGIA KAAAAVPLTR TGMVVGTAQY VSPEQAQGKE 200
    VTAASDIYSL GVVGYEMMAG RRPFTGDSSV SVAIAHINQA PPQMPTSISA 250
    QTRELIGIAL RKDPGRRFPD GNEMALAVSA VRLGKRPPQP RTSAMMAQAE 300
    APSPSESTAM LGRVARPATI TQEAAPKRGS GIGIGLFIAA LLAVIIGAVI 350
    YAGTTGILFN DTPEETTTPE TITETYTPTV EETTSQWVPP TPPTRSTFTE 400
    PETTSHRPTT SEESTSEEPT TEAPTSSRTV PQIPTSTPRT SASVPVETNA 450
    PADDLIDAVN GLLDVGGAQ 469
    Length:469
    Mass (Da):50,375
    Last modified:October 1, 2002 - v1
    Checksum:i53C10AD97BB95595
    GO

    Sequence cautioni

    The sequence BAB88662.1 differs from that shown. Reason: Frameshift at position 348.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti119 – 1191R → S in BAB88662. 1 PublicationCurated
    Sequence conflicti143 – 1431D → N in BAB88662. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB083046 Genomic DNA. Translation: BAB88662.1. Frameshift.
    BA000036 Genomic DNA. Translation: BAB97435.1.
    BX927148 Genomic DNA. Translation: CAF18610.1.
    RefSeqiNP_599294.1. NC_003450.3.
    YP_224339.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB97435; BAB97435; BAB97435.
    CAF18610; CAF18610; cg0059.
    GeneIDi1021413.
    KEGGicgb:cg0059.
    cgl:NCgl0041.
    PATRICi21492120. VBICorGlu203724_0043.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB083046 Genomic DNA. Translation: BAB88662.1 . Frameshift.
    BA000036 Genomic DNA. Translation: BAB97435.1 .
    BX927148 Genomic DNA. Translation: CAF18610.1 .
    RefSeqi NP_599294.1. NC_003450.3.
    YP_224339.1. NC_006958.1.

    3D structure databases

    ProteinModelPortali Q8NU97.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-48320N.
    STRINGi 196627.cg0059.

    PTM databases

    PhosSitei P0904601.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB97435 ; BAB97435 ; BAB97435 .
    CAF18610 ; CAF18610 ; cg0059 .
    GeneIDi 1021413.
    KEGGi cgb:cg0059.
    cgl:NCgl0041.
    PATRICi 21492120. VBICorGlu203724_0043.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000037187.
    KOi K08884.
    OMAi HGGMSTV.
    OrthoDBi EOG6B35XT.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "drp72 of Corynebacterium glutamicum."
      Hirano S., Kimura E., Kawahara Y., Sugimoto S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiPKN2_CORGL
    AccessioniPrimary (citable) accession number: Q8NU97
    Secondary accession number(s): Q8RQP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3