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Protein

Serine/threonine-protein kinases PknA

Gene

pknA

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATPPROSITE-ProRule annotation
Active sitei148 – 1481Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: CACAO
  • transferase activity, transferring phosphorus-containing groups Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 960.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinases PknA (EC:2.7.11.1)
Gene namesi
Name:pknA
Synonyms:drp72
Ordered Locus Names:Cgl0042, cg0059
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001009 Componenti: Chromosome UP000000582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Serine/threonine-protein kinases PknAPRO_0000171199Add
BLAST

Interactioni

Protein-protein interaction databases

DIPiDIP-48320N.
STRINGi196627.cg0059.

Structurei

3D structure databases

ProteinModelPortaliQ8NU97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 281262Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi354 – 44087Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000037187.
KOiK08884.
OMAiASEHIDS.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NU97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQEDITGKD RLQELIGADY RLQWIIGHGG MSTVWLADDV VNDREVAIKV
60 70 80 90 100
LRPEFSDNQE FLNRFRNEAQ AAENIDSEHV VATYDYREVP DPAGHTFCFI
110 120 130 140 150
VMEFVRGESL ADLLEREGRL PEDLALDVME QAAHGLSVIH RMDMVHRDIK
160 170 180 190 200
PGNMLITANG IVKITDFGIA KAAAAVPLTR TGMVVGTAQY VSPEQAQGKE
210 220 230 240 250
VTAASDIYSL GVVGYEMMAG RRPFTGDSSV SVAIAHINQA PPQMPTSISA
260 270 280 290 300
QTRELIGIAL RKDPGRRFPD GNEMALAVSA VRLGKRPPQP RTSAMMAQAE
310 320 330 340 350
APSPSESTAM LGRVARPATI TQEAAPKRGS GIGIGLFIAA LLAVIIGAVI
360 370 380 390 400
YAGTTGILFN DTPEETTTPE TITETYTPTV EETTSQWVPP TPPTRSTFTE
410 420 430 440 450
PETTSHRPTT SEESTSEEPT TEAPTSSRTV PQIPTSTPRT SASVPVETNA
460
PADDLIDAVN GLLDVGGAQ
Length:469
Mass (Da):50,375
Last modified:October 1, 2002 - v1
Checksum:i53C10AD97BB95595
GO

Sequence cautioni

The sequence BAB88662.1 differs from that shown. Reason: Frameshift at position 348. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191R → S in BAB88662 (Ref. 1) Curated
Sequence conflicti143 – 1431D → N in BAB88662 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083046 Genomic DNA. Translation: BAB88662.1. Frameshift.
BA000036 Genomic DNA. Translation: BAB97435.1.
BX927148 Genomic DNA. Translation: CAF18610.1.
RefSeqiNP_599294.1. NC_003450.3.
WP_011013341.1. NC_006958.1.
YP_224339.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB97435; BAB97435; BAB97435.
CAF18610; CAF18610; cg0059.
GeneIDi1021413.
23503792.
KEGGicgb:cg0059.
cgl:NCgl0041.
PATRICi21492120. VBICorGlu203724_0043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083046 Genomic DNA. Translation: BAB88662.1. Frameshift.
BA000036 Genomic DNA. Translation: BAB97435.1.
BX927148 Genomic DNA. Translation: CAF18610.1.
RefSeqiNP_599294.1. NC_003450.3.
WP_011013341.1. NC_006958.1.
YP_224339.1. NC_006958.1.

3D structure databases

ProteinModelPortaliQ8NU97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48320N.
STRINGi196627.cg0059.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB97435; BAB97435; BAB97435.
CAF18610; CAF18610; cg0059.
GeneIDi1021413.
23503792.
KEGGicgb:cg0059.
cgl:NCgl0041.
PATRICi21492120. VBICorGlu203724_0043.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000037187.
KOiK08884.
OMAiASEHIDS.
OrthoDBiEOG6B35XT.

Enzyme and pathway databases

BRENDAi2.7.11.1. 960.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "drp72 of Corynebacterium glutamicum."
    Hirano S., Kimura E., Kawahara Y., Sugimoto S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiPKN2_CORGL
AccessioniPrimary (citable) accession number: Q8NU97
Secondary accession number(s): Q8RQP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: October 1, 2002
Last modified: May 27, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.