Q8NTY7 (IOLG_CORGL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Cgl0164, cg0204

Organism

Corynebacterium glutamicum (Brevibacterium flavum)

Taxonomic identifier

1718 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352566

Sequences

	Sequence		Length	Mass (Da)
	Q8NTY7 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: F5EF6EAFA65924A3	FASTA	337	36,431
	10 20 30 40 50 60 MSKSLRVGVV GAGAMGADHI DRINNRTSGA HISAIIEPDA ARAAAAAEDA PGAQAFTRIE 70 80 90 100 110 120 DAIAADAVDA VLIAVPGQFH EPVLVPALEA GLPILCEKPL TPDSESSLRI VELEQKLDKP 130 140 150 160 170 180 HIQVGFMRRF DPEYNNLRKL VESGEAGELL MLRGLHRNPS VGESYTQSML ITDSVVHEFD 190 200 210 220 230 240 VIPWLAGSRV VSVEVKYPKT SSLAHSGLKE PILVIMELEN GVLVDVEMNV NIQFGYQVAT 250 260 270 280 290 300 EAVFEKGLAR IGQPSGMQRW RDGEFLINEH TDFTTRFATA YDRQIQSWVD AVHEGTLVAG 310 320 330 PNAWDGYLVA LSCEAGVKAL DGGVIPVDAA PRPDFYA

References

[1]

"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032." Nakagawa S. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

[2]

"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins." Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A. J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000036 Genomic DNA. Translation: BAB97557.1. BX927148 Genomic DNA. Translation: CAF18731.1.
RefSeq	NP_599416.1. NC_003450.3. YP_224460.1. NC_006958.1.
3D structure databases
ProteinModelPortal	Q8NTY7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1021235. 3342797.
GenomeReviews	Gene locus Cgl0164 in contig BA000036_GR. Gene locus cg0204 in contig BX927147_GR.
KEGG	cgb:cg0204. cgl:NCgl0161.
PATRIC	21492378. VBICorGlu203724_0168.
Phylogenomic databases
HOGENOM	HBG612336.
OMA	RTEVVGE.
ProtClustDB	CLSK632711.
Enzyme and pathway databases
BioCyc	CGLU196627:CG0204-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_CORGL

Accession

Primary (citable) accession number: Q8NTY7
Secondary accession number(s): Q6M8J3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program