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Protein

Endonuclease III

Gene

nth

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi212Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi219Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi222Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi228Iron-sulfur (4Fe-4S)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, EndonucleaseImported, GlycosidaseUniRule annotation, Hydrolase, LyaseUniRule annotation, Nuclease
Biological processDNA damage, DNA repairUniRule annotation
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciCORYNE:G18NG-9849-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease IIIUniRule annotation (EC:4.2.99.18UniRule annotation)
Alternative name(s):
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation
Gene namesi
Name:nthUniRule annotation
Ordered Locus Names:Cgl0293Imported
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)Imported
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi196627.cg0353

Structurei

3D structure databases

ProteinModelPortaliQ8NTL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 210ENDO3cInterPro annotationAdd BLAST148

Sequence similaritiesi

Belongs to the Nth/MutY family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSM Bacteria
COG0177 LUCA
HOGENOMiHOG000252208
KOiK10773
OMAiKAKNPLC

Family and domain databases

CDDicd00056 ENDO3c, 1 hit
Gene3Di1.10.1670.10, 2 hits
HAMAPiMF_00942 Nth, 1 hit
InterProiView protein in InterPro
IPR011257 DNA_glycosylase
IPR004036 Endonuclease-III-like_CS2
IPR003651 Endonuclease3_FeS-loop_motif
IPR003265 HhH-GPD_domain
IPR000445 HhH_motif
IPR023170 HTH_base_excis_C
IPR005759 Nth
PfamiView protein in Pfam
PF00633 HHH, 1 hit
PF00730 HhH-GPD, 1 hit
SMARTiView protein in SMART
SM00478 ENDO3c, 1 hit
SM00525 FES, 1 hit
SUPFAMiSSF48150 SSF48150, 1 hit
TIGRFAMsiTIGR01083 nth, 1 hit
PROSITEiView protein in PROSITE
PS01155 ENDONUCLEASE_III_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NTL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSITPQKRP RVGSHIANKG QETDIGRKRR ARRINRTLTV AYPDAHCELD
60 70 80 90 100
FTNPLELTVA TILSAQCTDV RVNQVTPALF KRYPTATDYA NADRTELEEF
110 120 130 140 150
IRPTGFYRNK ATSLIGLGEA LISLHDGQVP GTLEQLVELP GVGRKTANVV
160 170 180 190 200
LGNAFGVPGI TVDTHFGRLV RRLKLTDEED PVKVEKVMNE LIEKPEWTMF
210 220 230 240 250
SHRLIFHGRR ICHSRRAACG ACMLAADCPS FGLEGPSDPF EAQKLIKSDD
260
REHLLKMAGM
Length:260
Mass (Da):28,918
Last modified:October 1, 2002 - v1
Checksum:i823BACDBDE55190F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAB97686.1
RefSeqiNP_599545.1, NC_003450.3
WP_011013539.1, NC_006958.1

Genome annotation databases

EnsemblBacteriaiBAB97686; BAB97686; BAB97686
GeneIDi1021358
KEGGicgl:NCgl0288
PATRICifig|196627.13.peg.297

Similar proteinsi

Entry informationi

Entry nameiQ8NTL4_CORGL
AccessioniPrimary (citable) accession number: Q8NTL4
Secondary accession number(s): Q6M869
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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