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Protein

Probable 5-dehydro-4-deoxyglucarate dehydratase

Gene

Cgl0453

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + H2O + CO2.UniRule annotation

Pathwayi: D-glucarate degradation

This protein is involved in step 2 of the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable 5-dehydro-4-deoxyglucarate dehydratase (Cgl0453)
This subpathway is part of the pathway D-glucarate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate, the pathway D-glucarate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciCORYNE:G18NG-10010-MONOMER.
UniPathwayiUPA00564; UER00628.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-dehydro-4-deoxyglucarate dehydrataseUniRule annotation (EC:4.2.1.41UniRule annotation)
Alternative name(s):
5-keto-4-deoxy-glucarate dehydrataseUniRule annotation
Short name:
KDGDHUniRule annotation
Gene namesi
Ordered Locus Names:Cgl0453, cg0536
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001032321 – 316Probable 5-dehydro-4-deoxyglucarate dehydrataseAdd BLAST316

Interactioni

Protein-protein interaction databases

STRINGi196627.cg0536.

Structurei

3D structure databases

ProteinModelPortaliQ8NT57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105UVJ. Bacteria.
COG0329. LUCA.
HOGENOMiHOG000173605.
KOiK01707.
OMAiRNRKKGY.

Family and domain databases

CDDicd00951. KDGDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NT57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFSPQDLA DHLKDGLLSF PATAFQDDLE VDEAAYVEHI EWQSSYPVAG
60 70 80 90 100
LFAAGGTGEG FSLTVEENHR VTQLAVQASS PEVPVLGSAT GSTKSAIANA
110 120 130 140 150
QGAEAAGAEG VLLLPPYLTE CDAEGLYNHA AAVCESTSLG VIVYNRANAI
160 170 180 190 200
YSPEVIARLS ERYPNFIGFK DGTGNIEHLA KITTLCGDRL FYLGGLPTAE
210 220 230 240 250
TFALPLLQMG MSTYSSAMFN FIPDFALSFY ADVRAQDSAA VKQKLSDFVL
260 270 280 290 300
PYLDIRDRAQ GYGVSIVKGG LKAVGRNAGG VRPPLRNLSE QDIADLSDLL
310
ATSGAGSYRL PVEVKA
Length:316
Mass (Da):33,552
Last modified:October 1, 2002 - v1
Checksum:iA55032EC319157D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB97846.1.
BX927149 Genomic DNA. Translation: CAF19169.1.
RefSeqiNP_599700.1. NC_003450.3.
WP_003860476.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB97846; BAB97846; BAB97846.
CAF19169; CAF19169; cg0536.
GeneIDi1021455.
KEGGicgb:cg0536.
cgl:NCgl0438.
PATRICi21492962. VBICorGlu203724_0452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB97846.1.
BX927149 Genomic DNA. Translation: CAF19169.1.
RefSeqiNP_599700.1. NC_003450.3.
WP_003860476.1. NC_006958.1.

3D structure databases

ProteinModelPortaliQ8NT57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg0536.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB97846; BAB97846; BAB97846.
CAF19169; CAF19169; cg0536.
GeneIDi1021455.
KEGGicgb:cg0536.
cgl:NCgl0438.
PATRICi21492962. VBICorGlu203724_0452.

Phylogenomic databases

eggNOGiENOG4105UVJ. Bacteria.
COG0329. LUCA.
HOGENOMiHOG000173605.
KOiK01707.
OMAiRNRKKGY.

Enzyme and pathway databases

UniPathwayiUPA00564; UER00628.
BioCyciCORYNE:G18NG-10010-MONOMER.

Family and domain databases

CDDicd00951. KDGDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKDGD_CORGL
AccessioniPrimary (citable) accession number: Q8NT57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.