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Protein

GDP-mannose-dependent alpha-mannosyltransferase

Gene

mgtA

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the addition of a mannose residue from GDP-D-mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D-mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluronic acid)-(1-3)-glycerol(ManGlcAGroAc2).2 Publications

Pathwayi: phosphatidylinositol metabolism

This protein is involved in the pathway phosphatidylinositol metabolism, which is part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol metabolism and in Phospholipid metabolism.

GO - Molecular functioni

  • mannosyltransferase activity Source: UniProtKB

GO - Biological processi

  • glycolipid biosynthetic process Source: UniProtKB
  • mannosylation Source: GOC
  • phosphatidylinositol metabolic process Source: UniProtKB-UniPathway
  • phospholipid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00949.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-mannose-dependent alpha-mannosyltransferase (EC:2.4.1.-)
Alternative name(s):
Guanosine diphosphomannose-dependent alpha-mannosyltransferase
Gene namesi
Name:mgtA
Ordered Locus Names:Cgl0469, cg0554
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413GDP-mannose-dependent alpha-mannosyltransferasePRO_0000393730Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196627.cg0554.

Structurei

3D structure databases

ProteinModelPortaliQ8NT41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family.Curated

Phylogenomic databases

eggNOGiENOG4105BZF. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077285.
KOiK12583.
OMAiWQRGVDT.
OrthoDBiEOG68DD0W.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NT41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIIRPMRVA IVAESFLPNV NGVTNSVLRV LEHLKANGHD ALVIAPGARD
60 70 80 90 100
FEEEIGHYLG FEIVRVPTVR VPLIDSLPIG VPLPSVTSVL REYNPDIIHL
110 120 130 140 150
ASPFVLGGAA AFAARQLRIP AIAIYQTDVA GFSQRYHLAP LATASWEWIK
160 170 180 190 200
TVHNMCQRTL APSSMSIDEL RDHGINDIFH WARGVDSKRF HPGKRSVALR
210 220 230 240 250
KSWDPSGAKK IVGFVGRLAS EKGVECLAGL SGRSDIQLVI VGDGPEAKYL
260 270 280 290 300
QEMMPDAIFT GALGGEELAT TYASLDLFVH PGEFETFCQA IQEAQASGVP
310 320 330 340 350
TIGPRAGGPI DLINEGVNGL LLDVVDFKET LPAAAEWILD DSRHSEMCAA
360 370 380 390 400
AWEGVKDKTW EALCTQLLQH YADVIALSQR IPLTFFGPSA EVAKLPLWVA
410
RALGVRTRIS IEA
Length:413
Mass (Da):44,919
Last modified:October 1, 2002 - v1
Checksum:i3D5DBE9BFBFC6EB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB97862.1.
BX927149 Genomic DNA. Translation: CAF19183.1.
RefSeqiNP_599714.1. NC_003450.3.

Genome annotation databases

EnsemblBacteriaiBAB97862; BAB97862; BAB97862.
CAF19183; CAF19183; cg0554.
GeneIDi1021476.
KEGGicgb:cg0554.
cgl:NCgl0452.
PATRICi21492992. VBICorGlu203724_0467.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB97862.1.
BX927149 Genomic DNA. Translation: CAF19183.1.
RefSeqiNP_599714.1. NC_003450.3.

3D structure databases

ProteinModelPortaliQ8NT41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg0554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB97862; BAB97862; BAB97862.
CAF19183; CAF19183; cg0554.
GeneIDi1021476.
KEGGicgb:cg0554.
cgl:NCgl0452.
PATRICi21492992. VBICorGlu203724_0467.

Phylogenomic databases

eggNOGiENOG4105BZF. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077285.
KOiK12583.
OMAiWQRGVDT.
OrthoDBiEOG68DD0W.

Enzyme and pathway databases

UniPathwayiUPA00949.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. "Inactivation of Corynebacterium glutamicum NCgl0452 and the role of MgtA in the biosynthesis of a novel mannosylated glycolipid involved in lipomannan biosynthesis."
    Tatituri R.V., Illarionov P.A., Dover L.G., Nigou J., Gilleron M., Hitchen P., Krumbach K., Morris H.R., Spencer N., Dell A., Eggeling L., Besra G.S.
    J. Biol. Chem. 282:4561-4572(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS MANNOSYLTRANSFERASE, NOMENCLATURE.
  4. "Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis."
    Mishra A.K., Batt S., Krumbach K., Eggeling L., Besra G.S.
    J. Bacteriol. 191:4465-4472(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MANGLCAGROAC2 BIOSYNTHESIS.

Entry informationi

Entry nameiMGTA_CORGL
AccessioniPrimary (citable) accession number: Q8NT41
Secondary accession number(s): Q6M7Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.