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Q8NSL3

- PRPD2_CORGL

UniProt

Q8NSL3 - PRPD2_CORGL

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Protein

2-methylcitrate dehydratase 2

Gene
prpD2, Cgl0657, cg0759
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate By similarity.

Catalytic activityi

(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.

Pathwayi

GO - Molecular functioni

  1. 2-methylcitrate dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. propionate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciCGLU196627:GJDM-651-MONOMER.
UniPathwayiUPA00946.

Names & Taxonomyi

Protein namesi
Recommended name:
2-methylcitrate dehydratase 2 (EC:4.2.1.79)
Gene namesi
Name:prpD2
Ordered Locus Names:Cgl0657, cg0759
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5045042-methylcitrate dehydratase 2PRO_0000215022Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196627.cg0759.

Structurei

3D structure databases

ProteinModelPortaliQ8NSL3.

Family & Domainsi

Sequence similaritiesi

Belongs to the PrpD family.

Phylogenomic databases

eggNOGiCOG2079.
HOGENOMiHOG000242813.
KOiK01720.
OMAiRETIELW.
OrthoDBiEOG6RC3K5.

Family and domain databases

InterProiIPR005656. MmgE_PrpD.
[Graphical view]
PANTHERiPTHR16943. PTHR16943. 1 hit.
PfamiPF03972. MmgE_PrpD. 1 hit.
[Graphical view]
SUPFAMiSSF103378. SSF103378. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NSL3-1 [UniParc]FASTAAdd to Basket

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MINHEVRTHR SAEEFPYEEH LAHKIARVAA DPVEVAADTQ EMIINRIIDN    50
ASVQAASVLR RPVSSARAMA QVRPVTDGRG ASVFGLPGRY AAEWAALANG 100
TAVRELDFHD TFLAAEYSHP GDNIPPILAA AQQAGKGGKD LIRGIATGYE 150
IQVNLVRGMC LHEHKIDHVA HLGPSAAAGI GTLLDLDVDT IYQAIGQALH 200
TTTATRQSRK GAISSWKAFA PAFAGKMSIE AVDRAMRGEG APSPIWEGED 250
GVIAWLLSGL DHIYTIPLPA EGEAKRAILD TYTKEHSAEY QSQAPIDLAR 300
SMGEKLAAQG LDLRDVDSIV LHTSHHTHYV IGTGSNDPQK FDPDASRETL 350
DHSIMYIFAV ALEDRAWHHE RSYAPERAHR RETIELWNKI STVEDPEWTR 400
RYHSVDPAEK AFGARAVITF KDGTVVEDEL AVADAHPLGA RPFAREQYIQ 450
KFRTLAEGVV SEKEQDRFLD AAQRTHELED LSELNIELDA DILAKAPVIP 500
EGLF 504
Length:504
Mass (Da):55,396
Last modified:September 19, 2002 - v1
Checksum:i12B6DFF430DD9D3B
GO

Sequence cautioni

The sequence BAB98050.1 differs from that shown. Reason: Frameshift at position 189.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF434799 Genomic DNA. Translation: AAM21504.1.
BA000036 Genomic DNA. Translation: BAB98050.1. Frameshift.
BX927149 Genomic DNA. Translation: CAF19363.1.
RefSeqiWP_011265602.1. NC_006958.1.
YP_224949.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98050; BAB98050; BAB98050.
CAF19363; CAF19363; cg0759.
KEGGicgb:cg0759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF434799 Genomic DNA. Translation: AAM21504.1 .
BA000036 Genomic DNA. Translation: BAB98050.1 . Frameshift.
BX927149 Genomic DNA. Translation: CAF19363.1 .
RefSeqi WP_011265602.1. NC_006958.1.
YP_224949.1. NC_006958.1.

3D structure databases

ProteinModelPortali Q8NSL3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg0759.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB98050 ; BAB98050 ; BAB98050 .
CAF19363 ; CAF19363 ; cg0759 .
KEGGi cgb:cg0759.

Phylogenomic databases

eggNOGi COG2079.
HOGENOMi HOG000242813.
KOi K01720.
OMAi RETIELW.
OrthoDBi EOG6RC3K5.

Enzyme and pathway databases

UniPathwayi UPA00946 .
BioCyci CGLU196627:GJDM-651-MONOMER.

Family and domain databases

InterProi IPR005656. MmgE_PrpD.
[Graphical view ]
PANTHERi PTHR16943. PTHR16943. 1 hit.
Pfami PF03972. MmgE_PrpD. 1 hit.
[Graphical view ]
SUPFAMi SSF103378. SSF103378. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two prpDBC gene clusters in Corynebacterium glutamicum and their involvement in propionate degradation via the 2-methylcitrate cycle."
    Claes W.A., Puehler A., Kalinowski J.
    J. Bacteriol. 184:2728-2739(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiPRPD2_CORGL
AccessioniPrimary (citable) accession number: Q8NSL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The prpD2B2C2 operon is essential for growth on propionate as sole carbon source.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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