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Q8NSL3

- PRPD2_CORGL

UniProt

Q8NSL3 - PRPD2_CORGL

Protein

2-methylcitrate dehydratase 2

Gene

prpD2

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (19 Sep 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate.By similarity

    Catalytic activityi

    (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.

    Pathwayi

    GO - Molecular functioni

    1. 2-methylcitrate dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. propionate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Enzyme and pathway databases

    BioCyciCGLU196627:GJDM-651-MONOMER.
    UniPathwayiUPA00946.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-methylcitrate dehydratase 2 (EC:4.2.1.79)
    Gene namesi
    Name:prpD2
    Ordered Locus Names:Cgl0657, cg0759
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5045042-methylcitrate dehydratase 2PRO_0000215022Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi196627.cg0759.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NSL3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PrpD family.Curated

    Phylogenomic databases

    eggNOGiCOG2079.
    HOGENOMiHOG000242813.
    KOiK01720.
    OMAiRETIELW.
    OrthoDBiEOG6RC3K5.

    Family and domain databases

    InterProiIPR005656. MmgE_PrpD.
    [Graphical view]
    PANTHERiPTHR16943. PTHR16943. 1 hit.
    PfamiPF03972. MmgE_PrpD. 1 hit.
    [Graphical view]
    SUPFAMiSSF103378. SSF103378. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8NSL3-1 [UniParc]FASTAAdd to Basket

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    MINHEVRTHR SAEEFPYEEH LAHKIARVAA DPVEVAADTQ EMIINRIIDN    50
    ASVQAASVLR RPVSSARAMA QVRPVTDGRG ASVFGLPGRY AAEWAALANG 100
    TAVRELDFHD TFLAAEYSHP GDNIPPILAA AQQAGKGGKD LIRGIATGYE 150
    IQVNLVRGMC LHEHKIDHVA HLGPSAAAGI GTLLDLDVDT IYQAIGQALH 200
    TTTATRQSRK GAISSWKAFA PAFAGKMSIE AVDRAMRGEG APSPIWEGED 250
    GVIAWLLSGL DHIYTIPLPA EGEAKRAILD TYTKEHSAEY QSQAPIDLAR 300
    SMGEKLAAQG LDLRDVDSIV LHTSHHTHYV IGTGSNDPQK FDPDASRETL 350
    DHSIMYIFAV ALEDRAWHHE RSYAPERAHR RETIELWNKI STVEDPEWTR 400
    RYHSVDPAEK AFGARAVITF KDGTVVEDEL AVADAHPLGA RPFAREQYIQ 450
    KFRTLAEGVV SEKEQDRFLD AAQRTHELED LSELNIELDA DILAKAPVIP 500
    EGLF 504
    Length:504
    Mass (Da):55,396
    Last modified:September 19, 2002 - v1
    Checksum:i12B6DFF430DD9D3B
    GO

    Sequence cautioni

    The sequence BAB98050.1 differs from that shown. Reason: Frameshift at position 189.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF434799 Genomic DNA. Translation: AAM21504.1.
    BA000036 Genomic DNA. Translation: BAB98050.1. Frameshift.
    BX927149 Genomic DNA. Translation: CAF19363.1.
    RefSeqiWP_011265602.1. NC_006958.1.
    YP_224949.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB98050; BAB98050; BAB98050.
    CAF19363; CAF19363; cg0759.
    KEGGicgb:cg0759.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF434799 Genomic DNA. Translation: AAM21504.1 .
    BA000036 Genomic DNA. Translation: BAB98050.1 . Frameshift.
    BX927149 Genomic DNA. Translation: CAF19363.1 .
    RefSeqi WP_011265602.1. NC_006958.1.
    YP_224949.1. NC_006958.1.

    3D structure databases

    ProteinModelPortali Q8NSL3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg0759.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB98050 ; BAB98050 ; BAB98050 .
    CAF19363 ; CAF19363 ; cg0759 .
    KEGGi cgb:cg0759.

    Phylogenomic databases

    eggNOGi COG2079.
    HOGENOMi HOG000242813.
    KOi K01720.
    OMAi RETIELW.
    OrthoDBi EOG6RC3K5.

    Enzyme and pathway databases

    UniPathwayi UPA00946 .
    BioCyci CGLU196627:GJDM-651-MONOMER.

    Family and domain databases

    InterProi IPR005656. MmgE_PrpD.
    [Graphical view ]
    PANTHERi PTHR16943. PTHR16943. 1 hit.
    Pfami PF03972. MmgE_PrpD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103378. SSF103378. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two prpDBC gene clusters in Corynebacterium glutamicum and their involvement in propionate degradation via the 2-methylcitrate cycle."
      Claes W.A., Puehler A., Kalinowski J.
      J. Bacteriol. 184:2728-2739(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiPRPD2_CORGL
    AccessioniPrimary (citable) accession number: Q8NSL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The prpD2B2C2 operon is essential for growth on propionate as sole carbon source.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3