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Q8NSJ4

- SYW_CORGL

UniProt

Q8NSJ4 - SYW_CORGL

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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei210 – 2101ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCGLU196627:GJDM-670-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:Cgl0677, cg0779
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Tryptophan--tRNA ligasePRO_0000136626Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi196627.cg0779.

Structurei

3D structure databases

ProteinModelPortaliQ8NSJ4.
SMRiQ8NSJ4. Positions 14-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi22 – 3110"HIGH" region
Motifi207 – 2115"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059940.
KOiK01867.
OMAiYFIPDMH.
OrthoDBiEOG686NJQ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NSJ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTQDKDLTA QTASRVLSGI QPTADSYHLG NYLGAVKQWI DLQDSYDAFY
60 70 80 90 100
FIPDLHAITV DQEPEELRNR TISGAAQLLA LGIDPERSTL FVQSHVPAHA
110 120 130 140 150
ELSWVLTCLT GFGEASRMTQ FKDKSSKRGA DRTSAGLFTY PMLMAADILL
160 170 180 190 200
YRPHLVPVGE DQRQHLELTR TLAERFNNRF GKAFEVPEGF IPQGASKIYD
210 220 230 240 250
LQNPTAKMSK SGDNPKGIIN LLDDPKVSTK RIKSAVTDND GVIAYDPENK
260 270 280 290 300
PGVSNLLVIQ SALTGTSIDS LVDGYQGAGY GALKGDTADA LEAFTTPLKA
310 320 330 340
KYDEYMNDRG ELERVLAIGA ERATEVANET LADVYDKIGF LASRR
Length:345
Mass (Da):37,827
Last modified:October 1, 2002 - v1
Checksum:i13A34953B0583455
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000036 Genomic DNA. Translation: BAB98070.1.
BX927149 Genomic DNA. Translation: CAF19382.1.
RefSeqiNP_599909.1. NC_003450.3.
YP_224968.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98070; BAB98070; BAB98070.
CAF19382; CAF19382; cg0779.
GeneIDi1018676.
3344474.
KEGGicgb:cg0779.
cgl:NCgl0647.
PATRICi21493396. VBICorGlu203724_0663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000036 Genomic DNA. Translation: BAB98070.1 .
BX927149 Genomic DNA. Translation: CAF19382.1 .
RefSeqi NP_599909.1. NC_003450.3.
YP_224968.1. NC_006958.1.

3D structure databases

ProteinModelPortali Q8NSJ4.
SMRi Q8NSJ4. Positions 14-341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg0779.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB98070 ; BAB98070 ; BAB98070 .
CAF19382 ; CAF19382 ; cg0779 .
GeneIDi 1018676.
3344474.
KEGGi cgb:cg0779.
cgl:NCgl0647.
PATRICi 21493396. VBICorGlu203724_0663.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000059940.
KOi K01867.
OMAi YFIPDMH.
OrthoDBi EOG686NJQ.

Enzyme and pathway databases

BioCyci CGLU196627:GJDM-670-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiSYW_CORGL
AccessioniPrimary (citable) accession number: Q8NSJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3