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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei147L-tryptophanUniRule annotation1
Binding sitei198ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 23ATPUniRule annotation3
Nucleotide bindingi30 – 31ATPUniRule annotation2
Nucleotide bindingi159 – 161ATPUniRule annotation3
Nucleotide bindingi207 – 211ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCORYNE:G18NG-10239-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:Cgl0677, cg0779
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366261 – 345Tryptophan--tRNA ligaseAdd BLAST345

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi196627.cg0779

Structurei

3D structure databases

ProteinModelPortaliQ8NSJ4
SMRiQ8NSJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 31"HIGH" regionUniRule annotation10
Motifi207 – 211"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059940
KOiK01867
OMAiQRMTQFK

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NSJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQDKDLTA QTASRVLSGI QPTADSYHLG NYLGAVKQWI DLQDSYDAFY
60 70 80 90 100
FIPDLHAITV DQEPEELRNR TISGAAQLLA LGIDPERSTL FVQSHVPAHA
110 120 130 140 150
ELSWVLTCLT GFGEASRMTQ FKDKSSKRGA DRTSAGLFTY PMLMAADILL
160 170 180 190 200
YRPHLVPVGE DQRQHLELTR TLAERFNNRF GKAFEVPEGF IPQGASKIYD
210 220 230 240 250
LQNPTAKMSK SGDNPKGIIN LLDDPKVSTK RIKSAVTDND GVIAYDPENK
260 270 280 290 300
PGVSNLLVIQ SALTGTSIDS LVDGYQGAGY GALKGDTADA LEAFTTPLKA
310 320 330 340
KYDEYMNDRG ELERVLAIGA ERATEVANET LADVYDKIGF LASRR
Length:345
Mass (Da):37,827
Last modified:October 1, 2002 - v1
Checksum:i13A34953B0583455
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAB98070.1
BX927149 Genomic DNA Translation: CAF19382.1
RefSeqiNP_599909.1, NC_003450.3
WP_011013808.1, NC_006958.1

Genome annotation databases

EnsemblBacteriaiBAB98070; BAB98070; BAB98070
CAF19382; CAF19382; cg0779
GeneIDi1018676
KEGGicgb:cg0779
cgl:NCgl0647
PATRICifig|196627.13.peg.663

Similar proteinsi

Entry informationi

Entry nameiSYW_CORGL
AccessioniPrimary (citable) accession number: Q8NSJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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