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Q8NSH9

- PRPD1_CORGL

UniProt

Q8NSH9 - PRPD1_CORGL

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Protein

2-methylcitrate dehydratase 1

Gene

prpD1

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate.By similarity

Catalytic activityi

(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.

GO - Molecular functioni

  1. 2-methylcitrate dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. propionate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
2-methylcitrate dehydratase 1 (EC:4.2.1.79)
Gene namesi
Name:prpD1
Ordered Locus Names:Cgl0694, cg0796
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4984982-methylcitrate dehydratase 1PRO_0000215021Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196627.cg0796.

Structurei

3D structure databases

ProteinModelPortaliQ8NSH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PrpD family.Curated

Phylogenomic databases

eggNOGiCOG2079.
HOGENOMiHOG000242813.
KOiK01720.
OMAiFRREEGI.
OrthoDBiEOG6RC3K5.

Family and domain databases

InterProiIPR005656. MmgE_PrpD.
[Graphical view]
PANTHERiPTHR16943. PTHR16943. 1 hit.
PfamiPF03972. MmgE_PrpD. 1 hit.
[Graphical view]
SUPFAMiSSF103378. SSF103378. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NSH9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIHDVYTHL SADNFPKAEH LAWKFSELAT DPVEVTPDVS EMIINRIIDN
60 70 80 90 100
AAVSAASVLR RPVTVARQQA QSHPREKGGK VFGISGSYSP EWAAFANGVA
110 120 130 140 150
VRELDFHDTF LAAEYSHPGD NIPPLLAVAQ AQRSSGRDLI RGIATAYEVQ
160 170 180 190 200
VELVRGICLH EHKIDHVAHL GPSAAAGLGT LLHVDEETIY QAIGQALHTT
210 220 230 240 250
TATRQSRKGE ISSWKAFAPA FAGKMAIEAM DRAMRGEGSP APIWEGEDGV
260 270 280 290 300
IAWLLSGKDH VYHVPLPEHG EPKLGILETY TKEHSAEYQS QAPIDLARRM
310 320 330 340 350
KPLVDAAGGT EHIAEIVLRT SHHTHYVIGT GANDPQKMDP QASRETLDHS
360 370 380 390 400
IMYIFAVALQ DGVWHHEFSY TRKRSTRPET VELWHKIRTV EDPEWTRRYH
410 420 430 440 450
SDDPAKKAFG AKAVITMADG TVIEDELAVA DAHPLGARPF ARENYIEKFR
460 470 480 490
TLAQGIVIDS EQERFLHAVQ SLPDLDDLDQ LNIEVDISNQ AATKAGLL
Length:498
Mass (Da):55,013
Last modified:September 19, 2002 - v1
Checksum:i626F96A36B9227C3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF434798 Genomic DNA. Translation: AAM21500.1.
BA000036 Genomic DNA. Translation: BAB98087.1.
BX927150 Genomic DNA. Translation: CAF19399.1.
RefSeqiNP_599926.1. NC_003450.3.
WP_011013821.1. NC_006958.1.
YP_224985.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98087; BAB98087; BAB98087.
CAF19399; CAF19399; cg0796.
GeneIDi1018693.
3343519.
KEGGicgb:cg0796.
cgl:NCgl0664.
PATRICi21493430. VBICorGlu203724_0680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF434798 Genomic DNA. Translation: AAM21500.1 .
BA000036 Genomic DNA. Translation: BAB98087.1 .
BX927150 Genomic DNA. Translation: CAF19399.1 .
RefSeqi NP_599926.1. NC_003450.3.
WP_011013821.1. NC_006958.1.
YP_224985.1. NC_006958.1.

3D structure databases

ProteinModelPortali Q8NSH9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg0796.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB98087 ; BAB98087 ; BAB98087 .
CAF19399 ; CAF19399 ; cg0796 .
GeneIDi 1018693.
3343519.
KEGGi cgb:cg0796.
cgl:NCgl0664.
PATRICi 21493430. VBICorGlu203724_0680.

Phylogenomic databases

eggNOGi COG2079.
HOGENOMi HOG000242813.
KOi K01720.
OMAi FRREEGI.
OrthoDBi EOG6RC3K5.

Family and domain databases

InterProi IPR005656. MmgE_PrpD.
[Graphical view ]
PANTHERi PTHR16943. PTHR16943. 1 hit.
Pfami PF03972. MmgE_PrpD. 1 hit.
[Graphical view ]
SUPFAMi SSF103378. SSF103378. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two prpDBC gene clusters in Corynebacterium glutamicum and their involvement in propionate degradation via the 2-methylcitrate cycle."
    Claes W.A., Puehler A., Kalinowski J.
    J. Bacteriol. 184:2728-2739(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiPRPD1_CORGL
AccessioniPrimary (citable) accession number: Q8NSH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The prpD1B1C1 operon seems not to be involved in propionate degradation.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3