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Q8NSH9

- PRPD1_CORGL

UniProt

Q8NSH9 - PRPD1_CORGL

Protein

2-methylcitrate dehydratase 1

Gene

prpD1

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (19 Sep 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate.By similarity

    Catalytic activityi

    (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.

    GO - Molecular functioni

    1. 2-methylcitrate dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. propionate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-methylcitrate dehydratase 1 (EC:4.2.1.79)
    Gene namesi
    Name:prpD1
    Ordered Locus Names:Cgl0694, cg0796
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4984982-methylcitrate dehydratase 1PRO_0000215021Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi196627.cg0796.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NSH9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PrpD family.Curated

    Phylogenomic databases

    eggNOGiCOG2079.
    HOGENOMiHOG000242813.
    KOiK01720.
    OMAiFRREEGI.
    OrthoDBiEOG6RC3K5.

    Family and domain databases

    InterProiIPR005656. MmgE_PrpD.
    [Graphical view]
    PANTHERiPTHR16943. PTHR16943. 1 hit.
    PfamiPF03972. MmgE_PrpD. 1 hit.
    [Graphical view]
    SUPFAMiSSF103378. SSF103378. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8NSH9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIHDVYTHL SADNFPKAEH LAWKFSELAT DPVEVTPDVS EMIINRIIDN    50
    AAVSAASVLR RPVTVARQQA QSHPREKGGK VFGISGSYSP EWAAFANGVA 100
    VRELDFHDTF LAAEYSHPGD NIPPLLAVAQ AQRSSGRDLI RGIATAYEVQ 150
    VELVRGICLH EHKIDHVAHL GPSAAAGLGT LLHVDEETIY QAIGQALHTT 200
    TATRQSRKGE ISSWKAFAPA FAGKMAIEAM DRAMRGEGSP APIWEGEDGV 250
    IAWLLSGKDH VYHVPLPEHG EPKLGILETY TKEHSAEYQS QAPIDLARRM 300
    KPLVDAAGGT EHIAEIVLRT SHHTHYVIGT GANDPQKMDP QASRETLDHS 350
    IMYIFAVALQ DGVWHHEFSY TRKRSTRPET VELWHKIRTV EDPEWTRRYH 400
    SDDPAKKAFG AKAVITMADG TVIEDELAVA DAHPLGARPF ARENYIEKFR 450
    TLAQGIVIDS EQERFLHAVQ SLPDLDDLDQ LNIEVDISNQ AATKAGLL 498
    Length:498
    Mass (Da):55,013
    Last modified:September 19, 2002 - v1
    Checksum:i626F96A36B9227C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF434798 Genomic DNA. Translation: AAM21500.1.
    BA000036 Genomic DNA. Translation: BAB98087.1.
    BX927150 Genomic DNA. Translation: CAF19399.1.
    RefSeqiNP_599926.1. NC_003450.3.
    WP_011013821.1. NC_006958.1.
    YP_224985.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB98087; BAB98087; BAB98087.
    CAF19399; CAF19399; cg0796.
    GeneIDi1018693.
    KEGGicgb:cg0796.
    cgl:NCgl0664.
    PATRICi21493430. VBICorGlu203724_0680.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF434798 Genomic DNA. Translation: AAM21500.1 .
    BA000036 Genomic DNA. Translation: BAB98087.1 .
    BX927150 Genomic DNA. Translation: CAF19399.1 .
    RefSeqi NP_599926.1. NC_003450.3.
    WP_011013821.1. NC_006958.1.
    YP_224985.1. NC_006958.1.

    3D structure databases

    ProteinModelPortali Q8NSH9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg0796.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB98087 ; BAB98087 ; BAB98087 .
    CAF19399 ; CAF19399 ; cg0796 .
    GeneIDi 1018693.
    KEGGi cgb:cg0796.
    cgl:NCgl0664.
    PATRICi 21493430. VBICorGlu203724_0680.

    Phylogenomic databases

    eggNOGi COG2079.
    HOGENOMi HOG000242813.
    KOi K01720.
    OMAi FRREEGI.
    OrthoDBi EOG6RC3K5.

    Family and domain databases

    InterProi IPR005656. MmgE_PrpD.
    [Graphical view ]
    PANTHERi PTHR16943. PTHR16943. 1 hit.
    Pfami PF03972. MmgE_PrpD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103378. SSF103378. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two prpDBC gene clusters in Corynebacterium glutamicum and their involvement in propionate degradation via the 2-methylcitrate cycle."
      Claes W.A., Puehler A., Kalinowski J.
      J. Bacteriol. 184:2728-2739(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiPRPD1_CORGL
    AccessioniPrimary (citable) accession number: Q8NSH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The prpD1B1C1 operon seems not to be involved in propionate degradation.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3