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Q8NSC4 (SAHH_CORGL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosylhomocysteinase
EC=3.3.1.1
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name=AdoHcyase
Gene names
Name:ahcY
Synonyms:sahH
Ordered Locus Names:Cgl0752, cg0860
OrganismCorynebacterium glutamicum (Brevibacterium flavum)
Taxonomic identifier1718 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine By similarity. HAMAP MF_00563

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563

Cofactor

Binds 1 NAD per subunit By similarity. HAMAP MF_00563

Pathway

Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563

Subcellular location

Cytoplasm By similarity HAMAP MF_00563.

Sequence similarities

Belongs to the adenosylhomocysteinase family.

Sequence caution

The sequence CAF19456.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474Adenosylhomocysteinase HAMAP MF_00563
PRO_0000116960

Regions

Nucleotide binding198 – 2003NAD By similarity
Nucleotide binding261 – 2666NAD By similarity
Nucleotide binding340 – 3423NAD By similarity

Sites

Binding site531Substrate By similarity
Binding site1351Substrate By similarity
Binding site1971Substrate By similarity
Binding site2271Substrate By similarity
Binding site2311Substrate By similarity
Binding site2321NAD By similarity
Binding site2841NAD By similarity
Binding site3191NAD By similarity
Binding site3881NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NSC4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 74673F92624C4F9D

FASTA47451,996
        10         20         30         40         50         60 
MDFKVADLSL AEAGRHQIRL AEYEMPGLMQ LRKEFADEQP LKGARIAGSI HMTVQTAVLI 

        70         80         90        100        110        120 
ETLTALGAEV RWASCNIFST QDEAAAAIVV GSGTVEEPAG VPVFAWKGES LEEYWWCINQ 

       130        140        150        160        170        180 
IFSWGDELPN MILDDGGDAT MAVIRGREYE QAGLVPPAEA NDSDEYIAFL GMLREVLAAE 

       190        200        210        220        230        240 
PGKWGKIAEA VKGVTEETTT GVHRLYHFAE EGVLPFPAMN VNDAVTKSKF DNKYGTRHSL 

       250        260        270        280        290        300 
IDGINRATDM LMGGKNVLVC GYGDVGKGCA EAFDGQGARV KVTEADPINA LQALMDGYSV 

       310        320        330        340        350        360 
VTVDEAIEDA DIVITATGNK DIISFEQMLK MKDHALLGNI GHFDNEIDMH SLLHRDDVTR 

       370        380        390        400        410        420 
TTIKPQVDEF TFSTGRSIIV LSEGRLLNLG NATGHPSFVM SNSFADQTIA QIELFQNEGQ 

       430        440        450        460        470 
YENEVYRLPK VLDEKVARIH VEALGGQLTE LTKEQAEYIG VDVAGPFKPE HYRY

« Hide

References

[1]"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032."
Nakagawa S.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[2]"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins."
Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. expand/collapse author list , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.
J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000036 Genomic DNA. Translation: BAB98145.1.
BX927150 Genomic DNA. Translation: CAF19456.1. Different initiation.
RefSeqNP_599981.1. NC_003450.3.
YP_225042.1. NC_006958.1.

3D structure databases

ProteinModelPortalQ8NSC4.
SMRQ8NSC4. Positions 2-474.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1018748.
3343536.
GenomeReviewsGene locus Cgl0752 in contig BA000036_GR.
Gene locus cg0860 in contig BX927147_GR.
KEGGcgb:cg0860.
cgl:NCgl0719.
PATRIC21493542. VBICorGlu203724_0736.

Phylogenomic databases

HOGENOMHBG352029.
OMASAQVWVT.
PhylomeDBQ8NSC4.
ProtClustDBPRK05476.

Enzyme and pathway databases

BioCycCGLU196627:CG0860-MONOMER.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSAHH_CORGL
AccessionPrimary (citable) accession number: Q8NSC4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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