Reviewed,
UniProtKB/Swiss-Prot Q8NSC4 (SAHH_CORGL)
Last modified
February 9, 2010.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Adenosylhomocysteinase EC=3.3.1.1 Alternative name(s): S-adenosyl-L-homocysteine hydrolase Short name=AdoHcyase | ||||||
| Gene names |
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| Organism | Corynebacterium glutamicum (Brevibacterium flavum) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1718 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium |
Protein attributes
| Sequence length | 474 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563 |
| Cofactor | Binds 1 NAD per subunit By similarity. HAMAP MF_00563 |
| Pathway | Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00563. |
| Sequence similarities | Belongs to the adenosylhomocysteinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | One-carbon metabolism |
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | adenosylhomocysteinase activity Inferred from electronic annotation. Source: HAMAP bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 474 | 474 | Adenosylhomocysteinase HAMAP MF_00563 | PRO_0000116960 | |||||
Regions | |||||||||
| Region | 224 – 392 | 169 | NAD binding By similarity | ||||||
Sites | |||||||||
| Binding site | 53 | 1 | Substrate By similarity | ||||||
| Binding site | 135 | 1 | Substrate By similarity | ||||||
| Binding site | 197 | 1 | Substrate By similarity | ||||||
| Binding site | 227 | 1 | Substrate By similarity | ||||||
| Binding site | 231 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Complete genomic sequence of Corynebacterium glutamicum ATCC 13032." Nakagawa S. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025. |
| [2] | "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins." Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. Tauch A.J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000036 Genomic DNA. Translation: BAB98145.1. BX927150 Genomic DNA. Translation: CAF19456.1. Different initiation. |
| RefSeq | NP_599981.1. YP_225042.1. |
3D structure databases | |
| SMR | Q8NSC4. Positions 2-474. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1018748. 3343536. |
| GenomeReviews | Gene locus Cgl0752 in contig BA000036_GR. |
| KEGG | cgb:cg0860. cgl:NCgl0719. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG352029. |
| OMA | VITHDHM. |
| PhylomeDB | Q8NSC4. |
Enzyme and pathway databases | |
| BioCyc | CGLU196627:CG0860-MONOMER. |
| BRENDA | 3.3.1.1. 812. |
Family and domain databases | |
| HAMAP | MF_00563_B. AdoHcyase_B. [Tree] |
| InterPro | IPR015878. Ado_hCys_hydrolase_NAD-bd. IPR016040. NAD(P)-bd_dom. IPR000043. S-Ado-L-homoCys_hydrolase. IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view] |
| PANTHER | PTHR23420. Ad_hcy_hydrolase. 1 hit. |
| Pfam | PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view] |
| PIRSF | PIRSF001109. Ad_hcy_hydrolase. 1 hit. |
| TIGRFAMs | TIGR00936. ahcY. 1 hit. |
| PROSITE | PS00738. ADOHCYASE_1. 1 hit. PS00739. ADOHCYASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SAHH_CORGL | ||||||||
| Accession | Primary (citable) accession number: Q8NSC4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


