Q8NS31 (G6PI_CORGL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	Cgl0851, cg0973

Organism

Corynebacterium glutamicum (Brevibacterium flavum)

Taxonomic identifier

1718 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	540 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 540	540	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180633
Sites
	Active site	351	1	Proton donor By similarity
	Active site	382	1	By similarity
	Active site	506	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8NS31 [UniParc]. Last modified October 10, 2002. Version 1. Checksum: FF5866693365EC69	FASTA	540	59,166
	10 20 30 40 50 60 MADISTTQVW QDLTDHYSNF QATTLRELFK EENRAEKYTF SAAGLHVDLS KNLLDDATLT 70 80 90 100 110 120 KLLALTEESG LRERIDAMFA GEHLNNTEDR AVLHTALRLP AEADLSVDGQ DVAADVHEVL 130 140 150 160 170 180 GRMRDFATAL RSGNWLGHTG HTIKKIVNIG IGGSDLGPAM ATKALRAYAT AGISAEFVSN 190 200 210 220 230 240 VDPADLVSVL EDLDAESTLF VIASKTFTTQ ETLSNARAAR AWLVEKLGEE AVAKHFVAVS 250 260 270 280 290 300 TNAEKVAEFG IDTDNMFGFW DWVGGRYSVD SAVGLSLMAV IGPRDFMRFL GGFHAMDEHF 310 320 330 340 350 360 RTTKFEENVP ILMALLGVWY SDFYGAETHA VLPYSEDLSR FAAYLQQLTM ESNGKSVHRD 370 380 390 400 410 420 GSPVSTGTGE IYWGEPGTNG QHAFFQLIHQ GTRLVPADFI GFARPKQDLP AGERTMHDLL 430 440 450 460 470 480 MSNFFAQTKV LAFGKNAEEI AAEGVAPELV NHKVMPGNRP TTTILAEELT PSILGALIAL 490 500 510 520 530 540 YEHIVMVQGV IWDINSFDQW GVELGKQQAN DLAPAVSGEE DVDSGDSSTD SLIKWYRANR

References

[1]	"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032." Nakagawa S. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[2]	"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins." Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A. J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000036 Genomic DNA. Translation: BAB98244.1. BX927150 Genomic DNA. Translation: CAF19557.1.
RefSeq	NP_600080.1. NC_003450.3. YP_225143.1. NC_006958.1.
3D structure databases
ProteinModelPortal	Q8NS31.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1018846. 3345267.
GenomeReviews	Gene locus Cgl0851 in contig BA000036_GR. Gene locus cg0973 in contig BX927147_GR.
KEGG	cgb:cg0973. cgl:NCgl0817.
PATRIC	21493754. VBICorGlu203724_0836.
Phylogenomic databases
HOGENOM	HBG352954.
OMA	NSLPAWT.
PhylomeDB	Q8NS31.
ProtClustDB	PRK00179.
Enzyme and pathway databases
BioCyc	CGLU196627:CG0973-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_CORGL

Accession

Primary (citable) accession number: Q8NS31

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 10, 2002
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program