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Q8NS31 (G6PI_CORGL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:Cgl0851, cg0973
OrganismCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) [Reference proteome] [HAMAP]
Taxonomic identifier196627 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180633

Sites

Active site3511Proton donor By similarity
Active site3821 By similarity
Active site5061 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NS31 [UniParc].

Last modified October 10, 2002. Version 1.
Checksum: FF5866693365EC69

FASTA54059,166
        10         20         30         40         50         60 
MADISTTQVW QDLTDHYSNF QATTLRELFK EENRAEKYTF SAAGLHVDLS KNLLDDATLT 

        70         80         90        100        110        120 
KLLALTEESG LRERIDAMFA GEHLNNTEDR AVLHTALRLP AEADLSVDGQ DVAADVHEVL 

       130        140        150        160        170        180 
GRMRDFATAL RSGNWLGHTG HTIKKIVNIG IGGSDLGPAM ATKALRAYAT AGISAEFVSN 

       190        200        210        220        230        240 
VDPADLVSVL EDLDAESTLF VIASKTFTTQ ETLSNARAAR AWLVEKLGEE AVAKHFVAVS 

       250        260        270        280        290        300 
TNAEKVAEFG IDTDNMFGFW DWVGGRYSVD SAVGLSLMAV IGPRDFMRFL GGFHAMDEHF 

       310        320        330        340        350        360 
RTTKFEENVP ILMALLGVWY SDFYGAETHA VLPYSEDLSR FAAYLQQLTM ESNGKSVHRD 

       370        380        390        400        410        420 
GSPVSTGTGE IYWGEPGTNG QHAFFQLIHQ GTRLVPADFI GFARPKQDLP AGERTMHDLL 

       430        440        450        460        470        480 
MSNFFAQTKV LAFGKNAEEI AAEGVAPELV NHKVMPGNRP TTTILAEELT PSILGALIAL 

       490        500        510        520        530        540 
YEHIVMVQGV IWDINSFDQW GVELGKQQAN DLAPAVSGEE DVDSGDSSTD SLIKWYRANR 

« Hide

References

[1]"The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
Ikeda M., Nakagawa S.
Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[2]"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins."
Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. expand/collapse author list , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.
J. Biotechnol. 104:5-25(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000036 Genomic DNA. Translation: BAB98244.1.
BX927150 Genomic DNA. Translation: CAF19557.1.
RefSeqNP_600080.1. NC_003450.3.
YP_225143.1. NC_006958.1.

3D structure databases

ProteinModelPortalQ8NS31.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196627.cg0973.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB98244; BAB98244; BAB98244.
CAF19557; CAF19557; cg0973.
GeneID1018846.
KEGGcgb:cg0973.
cgl:NCgl0817.
PATRIC21493754. VBICorGlu203724_0836.

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261370.
KOK01810.
OMAMIALTHY.
OrthoDBEOG64R61J.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_CORGL
AccessionPrimary (citable) accession number: Q8NS31
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways