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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei351Proton donorUniRule annotation1
Active sitei382UniRule annotation1
Active sitei506UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciCORYNE:G18NG-10421-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:Cgl0851, cg0973
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806331 – 540Glucose-6-phosphate isomeraseAdd BLAST540

Interactioni

Protein-protein interaction databases

STRINGi196627.cg0973.

Structurei

3D structure databases

ProteinModelPortaliQ8NS31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP8. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000261370.
KOiK01810.
OMAiSHLIAPY.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NS31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADISTTQVW QDLTDHYSNF QATTLRELFK EENRAEKYTF SAAGLHVDLS
60 70 80 90 100
KNLLDDATLT KLLALTEESG LRERIDAMFA GEHLNNTEDR AVLHTALRLP
110 120 130 140 150
AEADLSVDGQ DVAADVHEVL GRMRDFATAL RSGNWLGHTG HTIKKIVNIG
160 170 180 190 200
IGGSDLGPAM ATKALRAYAT AGISAEFVSN VDPADLVSVL EDLDAESTLF
210 220 230 240 250
VIASKTFTTQ ETLSNARAAR AWLVEKLGEE AVAKHFVAVS TNAEKVAEFG
260 270 280 290 300
IDTDNMFGFW DWVGGRYSVD SAVGLSLMAV IGPRDFMRFL GGFHAMDEHF
310 320 330 340 350
RTTKFEENVP ILMALLGVWY SDFYGAETHA VLPYSEDLSR FAAYLQQLTM
360 370 380 390 400
ESNGKSVHRD GSPVSTGTGE IYWGEPGTNG QHAFFQLIHQ GTRLVPADFI
410 420 430 440 450
GFARPKQDLP AGERTMHDLL MSNFFAQTKV LAFGKNAEEI AAEGVAPELV
460 470 480 490 500
NHKVMPGNRP TTTILAEELT PSILGALIAL YEHIVMVQGV IWDINSFDQW
510 520 530 540
GVELGKQQAN DLAPAVSGEE DVDSGDSSTD SLIKWYRANR
Length:540
Mass (Da):59,166
Last modified:October 10, 2002 - v1
Checksum:iFF5866693365EC69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB98244.1.
BX927150 Genomic DNA. Translation: CAF19557.1.
RefSeqiNP_600080.1. NC_003450.3.
WP_011013928.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98244; BAB98244; BAB98244.
CAF19557; CAF19557; cg0973.
GeneIDi1018846.
KEGGicgb:cg0973.
cgl:NCgl0817.
PATRICi21493754. VBICorGlu203724_0836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB98244.1.
BX927150 Genomic DNA. Translation: CAF19557.1.
RefSeqiNP_600080.1. NC_003450.3.
WP_011013928.1. NC_006958.1.

3D structure databases

ProteinModelPortaliQ8NS31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg0973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB98244; BAB98244; BAB98244.
CAF19557; CAF19557; cg0973.
GeneIDi1018846.
KEGGicgb:cg0973.
cgl:NCgl0817.
PATRICi21493754. VBICorGlu203724_0836.

Phylogenomic databases

eggNOGiENOG4107QP8. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000261370.
KOiK01810.
OMAiSHLIAPY.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciCORYNE:G18NG-10421-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_CORGL
AccessioniPrimary (citable) accession number: Q8NS31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.