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Q8NRZ6

- PMT_CORGL

UniProt

Q8NRZ6 - PMT_CORGL

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Protein

Probable dolichyl-phosphate-mannose--protein mannosyltransferase

Gene

pmt

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.By similarity

Catalytic activityi

Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein.

Pathwayi

GO - Molecular functioni

  1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciCGLU1204414-WGS:GSME-853-MONOMER.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dolichyl-phosphate-mannose--protein mannosyltransferase (EC:2.4.1.109)
Gene namesi
Name:pmt
Ordered Locus Names:Cgl0890, cg1014
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence AnalysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence AnalysisAdd
BLAST
Transmembranei388 – 40821HelicalSequence AnalysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence AnalysisAdd
BLAST
Transmembranei441 – 46121HelicalSequence AnalysisAdd
BLAST
Transmembranei485 – 50521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Loss of protein glycosylation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Probable dolichyl-phosphate-mannose--protein mannosyltransferasePRO_0000421157Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196627.cg1014.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 39 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000097888.
OMAiSHPWDSK.
OrthoDBiEOG68M4FH.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02366. PMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NRZ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQALPVRDQ GRDQGIFAGT LPPAPPKFKW TRLDTYTWAI IAVFALVTRF
60 70 80 90 100
TGLSSATASG TPVFDEKHYV PQAWDMVRSW INPITGGIES NPGYGLVVHP
110 120 130 140 150
PLAKQLEALG EWVFGYTPLG WRIMVAIFGT LTIFAIMAIA RRLSGSTMVT
160 170 180 190 200
FIAGILALAD GVLLVSSRFG MLDIFLVFFI TAAAWALIRD HQQMHQRLND
210 220 230 240 250
LLLTNGQITK DFGPRFGFRW WRFTTGVFLG LALSVKWSGL YYIAFFGLTS
260 270 280 290 300
VFLDLWLRKR YGVRRYVTGT LKNDVIPALG SLVIIPALLY IWSWRAWFAS
310 320 330 340 350
ETSVYRHAKT DGTITEDSIL QLFPESIAGW IHYHISVLEF HGSLTTSSGH
360 370 380 390 400
SHPWDSKPWA WLVSGRPILY FSSTDISCDV GGTCRRMIYL FGTPAIWWLT
410 420 430 440 450
VPVILWALWS FFARRSRGYV VPLVAFAAGF LPWLAAYDRQ MYFFYATALV
460 470 480 490 500
PFTIIMLALA CGELWGRGKM TPTGLTRGSM AVVTYISLVV MMFLAFSPLF
510 520
YGFVIPDYVY ESLMWFPSWR
Length:520
Mass (Da):58,734
Last modified:October 1, 2002 - v1
Checksum:i9F6C21ED4B20788D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB98283.1.
BX927150 Genomic DNA. Translation: CAF19596.1.
RefSeqiNP_600117.1. NC_003450.3.
YP_225182.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98283; BAB98283; BAB98283.
CAF19596; CAF19596; cg1014.
GeneIDi1018883.
3343200.
KEGGicgl:NCgl0854.
PATRICi21493828. VBICorGlu203724_0873.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB98283.1 .
BX927150 Genomic DNA. Translation: CAF19596.1 .
RefSeqi NP_600117.1. NC_003450.3.
YP_225182.1. NC_006958.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg1014.

Protocols and materials databases

DNASUi 1018883.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB98283 ; BAB98283 ; BAB98283 .
CAF19596 ; CAF19596 ; cg1014 .
GeneIDi 1018883.
3343200.
KEGGi cgl:NCgl0854.
PATRICi 21493828. VBICorGlu203724_0873.

Phylogenomic databases

HOGENOMi HOG000097888.
OMAi SHPWDSK.
OrthoDBi EOG68M4FH.

Enzyme and pathway databases

UniPathwayi UPA00378 .
BioCyci CGLU1204414-WGS:GSME-853-MONOMER.

Family and domain databases

InterProi IPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
[Graphical view ]
PANTHERi PTHR10050. PTHR10050. 1 hit.
Pfami PF02366. PMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. "The Corynebacterium glutamicum gene pmt encoding a glycosyltransferase related to eukaryotic protein-O-mannosyltransferases is essential for glycosylation of the resuscitation promoting factor (Rpf2) and other secreted proteins."
    Mahne M., Tauch A., Puhler A., Kalinowski J.
    FEMS Microbiol. Lett. 259:226-233(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiPMT_CORGL
AccessioniPrimary (citable) accession number: Q8NRZ6
Secondary accession number(s): Q6M6Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3