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Q8NRZ6

- PMT_CORGL

UniProt

Q8NRZ6 - PMT_CORGL

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Protein
Probable dolichyl-phosphate-mannose--protein mannosyltransferase
Gene
pmt, Cgl0890, cg1014
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins By similarity.

Catalytic activityi

Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

Pathwayi

GO - Molecular functioni

  1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciCGLU1204414-WGS:GSME-853-MONOMER.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dolichyl-phosphate-mannose--protein mannosyltransferase (EC:2.4.1.109)
Gene namesi
Name:pmt
Ordered Locus Names:Cgl0890, cg1014
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821Helical; Reviewed prediction
Add
BLAST
Transmembranei119 – 13921Helical; Reviewed prediction
Add
BLAST
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST
Transmembranei168 – 18821Helical; Reviewed prediction
Add
BLAST
Transmembranei237 – 25721Helical; Reviewed prediction
Add
BLAST
Transmembranei274 – 29421Helical; Reviewed prediction
Add
BLAST
Transmembranei388 – 40821Helical; Reviewed prediction
Add
BLAST
Transmembranei418 – 43821Helical; Reviewed prediction
Add
BLAST
Transmembranei441 – 46121Helical; Reviewed prediction
Add
BLAST
Transmembranei485 – 50521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Loss of protein glycosylation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Probable dolichyl-phosphate-mannose--protein mannosyltransferase
PRO_0000421157Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196627.cg1014.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000097888.
OMAiSHPWDSK.
OrthoDBiEOG68M4FH.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02366. PMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NRZ6-1 [UniParc]FASTAAdd to Basket

« Hide

MSQALPVRDQ GRDQGIFAGT LPPAPPKFKW TRLDTYTWAI IAVFALVTRF    50
TGLSSATASG TPVFDEKHYV PQAWDMVRSW INPITGGIES NPGYGLVVHP 100
PLAKQLEALG EWVFGYTPLG WRIMVAIFGT LTIFAIMAIA RRLSGSTMVT 150
FIAGILALAD GVLLVSSRFG MLDIFLVFFI TAAAWALIRD HQQMHQRLND 200
LLLTNGQITK DFGPRFGFRW WRFTTGVFLG LALSVKWSGL YYIAFFGLTS 250
VFLDLWLRKR YGVRRYVTGT LKNDVIPALG SLVIIPALLY IWSWRAWFAS 300
ETSVYRHAKT DGTITEDSIL QLFPESIAGW IHYHISVLEF HGSLTTSSGH 350
SHPWDSKPWA WLVSGRPILY FSSTDISCDV GGTCRRMIYL FGTPAIWWLT 400
VPVILWALWS FFARRSRGYV VPLVAFAAGF LPWLAAYDRQ MYFFYATALV 450
PFTIIMLALA CGELWGRGKM TPTGLTRGSM AVVTYISLVV MMFLAFSPLF 500
YGFVIPDYVY ESLMWFPSWR 520
Length:520
Mass (Da):58,734
Last modified:October 1, 2002 - v1
Checksum:i9F6C21ED4B20788D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000036 Genomic DNA. Translation: BAB98283.1.
BX927150 Genomic DNA. Translation: CAF19596.1.
RefSeqiNP_600117.1. NC_003450.3.
YP_225182.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98283; BAB98283; BAB98283.
CAF19596; CAF19596; cg1014.
GeneIDi1018883.
KEGGicgb:cg1014.
cgl:NCgl0854.
PATRICi21493828. VBICorGlu203724_0873.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000036 Genomic DNA. Translation: BAB98283.1 .
BX927150 Genomic DNA. Translation: CAF19596.1 .
RefSeqi NP_600117.1. NC_003450.3.
YP_225182.1. NC_006958.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg1014.

Protocols and materials databases

DNASUi 1018883.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB98283 ; BAB98283 ; BAB98283 .
CAF19596 ; CAF19596 ; cg1014 .
GeneIDi 1018883.
KEGGi cgb:cg1014.
cgl:NCgl0854.
PATRICi 21493828. VBICorGlu203724_0873.

Phylogenomic databases

HOGENOMi HOG000097888.
OMAi SHPWDSK.
OrthoDBi EOG68M4FH.

Enzyme and pathway databases

UniPathwayi UPA00378 .
BioCyci CGLU1204414-WGS:GSME-853-MONOMER.

Family and domain databases

InterProi IPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
[Graphical view ]
PANTHERi PTHR10050. PTHR10050. 1 hit.
Pfami PF02366. PMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. "The Corynebacterium glutamicum gene pmt encoding a glycosyltransferase related to eukaryotic protein-O-mannosyltransferases is essential for glycosylation of the resuscitation promoting factor (Rpf2) and other secreted proteins."
    Mahne M., Tauch A., Puhler A., Kalinowski J.
    FEMS Microbiol. Lett. 259:226-233(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiPMT_CORGL
AccessioniPrimary (citable) accession number: Q8NRZ6
Secondary accession number(s): Q6M6Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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