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Q8NRZ6

- PMT_CORGL

UniProt

Q8NRZ6 - PMT_CORGL

Protein

Probable dolichyl-phosphate-mannose--protein mannosyltransferase

Gene

pmt

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.By similarity

    Catalytic activityi

    Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

    Pathwayi

    GO - Molecular functioni

    1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciCGLU1204414-WGS:GSME-853-MONOMER.
    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dolichyl-phosphate-mannose--protein mannosyltransferase (EC:2.4.1.109)
    Gene namesi
    Name:pmt
    Ordered Locus Names:Cgl0890, cg1014
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Loss of protein glycosylation.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Probable dolichyl-phosphate-mannose--protein mannosyltransferasePRO_0000421157Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi196627.cg1014.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei119 – 13921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei388 – 40821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei441 – 46121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei485 – 50521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 39 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000097888.
    OMAiSHPWDSK.
    OrthoDBiEOG68M4FH.

    Family and domain databases

    InterProiIPR027005. GlyclTrfase_39_like.
    IPR003342. Glyco_trans_39.
    [Graphical view]
    PANTHERiPTHR10050. PTHR10050. 1 hit.
    PfamiPF02366. PMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NRZ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQALPVRDQ GRDQGIFAGT LPPAPPKFKW TRLDTYTWAI IAVFALVTRF    50
    TGLSSATASG TPVFDEKHYV PQAWDMVRSW INPITGGIES NPGYGLVVHP 100
    PLAKQLEALG EWVFGYTPLG WRIMVAIFGT LTIFAIMAIA RRLSGSTMVT 150
    FIAGILALAD GVLLVSSRFG MLDIFLVFFI TAAAWALIRD HQQMHQRLND 200
    LLLTNGQITK DFGPRFGFRW WRFTTGVFLG LALSVKWSGL YYIAFFGLTS 250
    VFLDLWLRKR YGVRRYVTGT LKNDVIPALG SLVIIPALLY IWSWRAWFAS 300
    ETSVYRHAKT DGTITEDSIL QLFPESIAGW IHYHISVLEF HGSLTTSSGH 350
    SHPWDSKPWA WLVSGRPILY FSSTDISCDV GGTCRRMIYL FGTPAIWWLT 400
    VPVILWALWS FFARRSRGYV VPLVAFAAGF LPWLAAYDRQ MYFFYATALV 450
    PFTIIMLALA CGELWGRGKM TPTGLTRGSM AVVTYISLVV MMFLAFSPLF 500
    YGFVIPDYVY ESLMWFPSWR 520
    Length:520
    Mass (Da):58,734
    Last modified:October 1, 2002 - v1
    Checksum:i9F6C21ED4B20788D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB98283.1.
    BX927150 Genomic DNA. Translation: CAF19596.1.
    RefSeqiNP_600117.1. NC_003450.3.
    YP_225182.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB98283; BAB98283; BAB98283.
    CAF19596; CAF19596; cg1014.
    GeneIDi1018883.
    KEGGicgb:cg1014.
    cgl:NCgl0854.
    PATRICi21493828. VBICorGlu203724_0873.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB98283.1 .
    BX927150 Genomic DNA. Translation: CAF19596.1 .
    RefSeqi NP_600117.1. NC_003450.3.
    YP_225182.1. NC_006958.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg1014.

    Protocols and materials databases

    DNASUi 1018883.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB98283 ; BAB98283 ; BAB98283 .
    CAF19596 ; CAF19596 ; cg1014 .
    GeneIDi 1018883.
    KEGGi cgb:cg1014.
    cgl:NCgl0854.
    PATRICi 21493828. VBICorGlu203724_0873.

    Phylogenomic databases

    HOGENOMi HOG000097888.
    OMAi SHPWDSK.
    OrthoDBi EOG68M4FH.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    BioCyci CGLU1204414-WGS:GSME-853-MONOMER.

    Family and domain databases

    InterProi IPR027005. GlyclTrfase_39_like.
    IPR003342. Glyco_trans_39.
    [Graphical view ]
    PANTHERi PTHR10050. PTHR10050. 1 hit.
    Pfami PF02366. PMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    3. "The Corynebacterium glutamicum gene pmt encoding a glycosyltransferase related to eukaryotic protein-O-mannosyltransferases is essential for glycosylation of the resuscitation promoting factor (Rpf2) and other secreted proteins."
      Mahne M., Tauch A., Puhler A., Kalinowski J.
      FEMS Microbiol. Lett. 259:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiPMT_CORGL
    AccessioniPrimary (citable) accession number: Q8NRZ6
    Secondary accession number(s): Q6M6Q4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2013
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3