Reviewed, UniProtKB/Swiss-Prot Q8NRV6 (PTH2_CORGL)

Names and origin

Protein names

Recommended name:
    Peptidyl-tRNA hydrolase 2
      Short name=PTH 2
    EC=3.1.1.29

Gene names

Name:	pth2
Ordered Locus Names:	Cgl0935, cg1067

Organism

Corynebacterium glutamicum (Brevibacterium flavum) [Complete proteome] [HAMAP]

Taxonomic identifier

1718 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity.
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Peptidyl-tRNA hydrolase 2 HAMAP MF_00083		PRO_0000187728

Sequences

	Sequence		Length	Mass (Da)
	Q8NRV6-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 1B5611D116680C77	FASTA	204	21,695
	10 20 30 40 50 60 MTSVSFLSKI QALFAPKPEL PAAKWLVVGL GNPGAKYEST RHNVGYMCQD MLIDAHQQQP 70 80 90 100 110 120 LTPATGYKAL TTQLAPGVLA VRSTTFMNHS GQGVAPIAAA LGIPAERIIV IHDELDLPAG 130 140 150 160 170 180 KVRLKKGGNE NGHNGLKSLT EELGTRDYLR VRIGISRPPA GMAVPDYVLE PVDHDQPGIE 190 200 LAAEAVDLLL AQGLSAAQNA IHSR

References

[1]

"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032." Nakagawa S. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

[2]

"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins." Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A. J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000036 Genomic DNA. Translation: BAB98328.1. BX927150 Genomic DNA. Translation: CAF19641.1. Different initiation.
RefSeq	NP_600163.1. YP_225227.1.
3D structure databases
HSSP	HSSP built from PDB template 2PTH based on UniProtKB P23932.
ModBase	Search...
Genome annotation databases
GeneID	1018927. 3345030.
GenomeReviews	Gene locus Cgl0935 in contig BA000036_GR. Gene locus cg1067 in contig BX927147_GR.
KEGG	cgb:cg1067. cgl:NCgl0898.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8NRV6.
OMA	TEIDINN.
Enzyme and pathway databases
BioCyc	CGLU196627-1:CG1067-MON.
BRENDA	3.1.1.29. 812.
Family and domain databases
HAMAP	MF_00083. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
ProDom	PD005324. PeptRNAhydrolase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00447. pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. False negative. PS01196. PEPT_TRNA_HYDROL_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH2_CORGL

Accession

Primary (citable) accession number: Q8NRV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	October 1, 2002
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)