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Protein

HTH-type transcriptional regulator RipA

Gene

ripA

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Under iron limitation, RipA negatively controls the expression of the acn (aconitase), catA (catechol 1,2 dioxygenase), leuCD (isopropylmalate dehydratase), narKGHJI (nitrite/nitrate transporter and nitrate reductase), sdhCAB (succinate dehydrogenase), pta (phosphotransacetylase) and katA (catalase) genes. Binds to the consensus sequence in the promoter region.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi113 – 159H-T-H motifPROSITE-ProRule annotationAdd BLAST47
DNA bindingi165 – 208H-T-H motifPROSITE-ProRule annotationAdd BLAST44

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciCORYNE:G18NG-10554-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator RipA1 Publication
Alternative name(s):
AraC-type regulator RipA1 Publication
Repressor of iron proteins A1 Publication
Short name:
RIPA1 Publication
Gene namesi
Name:ripA1 Publication
Ordered Locus Names:Cgl0982, cg1120
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

Under iron limitation, the ripA deletion mutant shows a 2-fold higher aconitase activity and a higher mRNA level for the acn, catA, leuCD, narKGHJI, sdhCAB and pta genes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232391 – 331HTH-type transcriptional regulator RipAAdd BLAST331

Proteomic databases

PRIDEiQ8NRR3

Expressioni

Inductioni

Repressed by DtxR under iron excess.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi196627.cg1120

Structurei

3D structure databases

ProteinModelPortaliQ8NRR3
SMRiQ8NRR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2207 LUCA
OMAiHPSECIA

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR018060 HTH_AraC
IPR018062 HTH_AraC-typ_CS
IPR011051 RmlC_Cupin_sf
PfamiView protein in Pfam
PF12833 HTH_18, 1 hit
SMARTiView protein in SMART
SM00342 HTH_ARAC, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
SSF51182 SSF51182, 1 hit
PROSITEiView protein in PROSITE
PS00041 HTH_ARAC_FAMILY_1, 1 hit
PS01124 HTH_ARAC_FAMILY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NRR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSASLLWCH SGVSTVRFGE RIFTLVAGDL LFAPEEAQVA DDSQGLVLNI
60 70 80 90 100
RFETLNIMGP ARRIHLGHVW NDRLTFEYSR SLFGKETLSP DIARLFTDRV
110 120 130 140 150
PTPPLPAPRK ARAVAQVLVS NPADQTSLEE FAEIQGVSAR TLQRQFLKST
160 170 180 190 200
GYSFSEWRAA QRVCVAASLL AHDFSISVVA NLVGFAATSS LTRAFRRHTG
210 220 230 240 250
ATPSTFTTGQ IGMGSAGHPP RIPATTTFAE AHQDQQLWIY SGTATVTTPG
260 270 280 290 300
YCRFMGQGDM VTIPAGTQTR IDVAAGSIAF PVPVGLDEWG MDLTRVVAVN
310 320 330
NQQPKPLTIL EQSEWSKLSE ELLNTPVPVQ M
Length:331
Mass (Da):36,045
Last modified:October 1, 2002 - v1
Checksum:i0F3449B8CFED20DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16 – 28VRFGE…TLVAG → SSVLAREFSLSSQA in AAS92713 (Ref. 3) CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAB98375.1
BX927150 Genomic DNA Translation: CAF19689.1
AY513595 Genomic DNA Translation: AAS92713.1
RefSeqiNP_600210.1, NC_003450.3
WP_011014026.1, NC_006958.1

Genome annotation databases

EnsemblBacteriaiBAB98375; BAB98375; BAB98375
CAF19689; CAF19689; cg1120
GeneIDi1018972
KEGGicgb:cg1120
cgl:NCgl0943
PATRICifig|196627.13.peg.966

Similar proteinsi

Entry informationi

Entry nameiRIPA_CORGL
AccessioniPrimary (citable) accession number: Q8NRR3
Secondary accession number(s): Q5QHF9, Q6M6H3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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