Q8NRQ2 (COAA_CORGL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	Cgl0995, cg1132

Organism

Corynebacterium glutamicum (Brevibacterium flavum)

Taxonomic identifier

1718 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.
Sequence caution	The sequence CAF19699.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Pantothenate kinase HAMAP MF_00215		PRO_0000194424
Regions
	Nucleotide binding	97 – 104	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8NRQ2 [UniParc]. Last modified October 10, 2002. Version 1. Checksum: BBDE9EF3C83F95F6	FASTA	312	35,316
	10 20 30 40 50 60 MKPSPRTPDF SPYLDFDRAQ WRELRNSMPQ VLTQKEVIEL RGIGENIDLA EVAEVYLPLS 70 80 90 100 110 120 RLIHLQVAAR QQLTAATETF LGTSPSISVP FVIGVAGSVA VGKSTTARLL QVLLQRWNSH 130 140 150 160 170 180 PRVDLVTTDG FLYPGAELIR RGLMSRKGFP ESYDQRALLR FVTDVKSGKL EVNAPVYSHT 190 200 210 220 230 240 AYDRVPGEFT TVRQPDILIV EGLNVLQTGP TLMVSDLFDF SVYVDARTED IEKWYIDRFL 250 260 270 280 290 300 KLRDTAFRRP GAHFSHYADM ADPESIAVAR ELWQSINLPN LVENILPTRV RASLVLKKGS 310 DHLVERVRMR KI

References

[1]	"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032." Nakagawa S. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[2]	"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins." Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A. J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000036 Genomic DNA. Translation: BAB98388.1. BX927151 Genomic DNA. Translation: CAF19699.1. Different initiation.
RefSeq	NP_600220.1. NC_003450.3. YP_225285.1. NC_006958.1.
3D structure databases
ProteinModelPortal	Q8NRQ2.
SMR	Q8NRQ2. Positions 11-312.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1018982. 3342901.
GenomeReviews	Gene locus Cgl0995 in contig BA000036_GR. Gene locus cg1132 in contig BX927147_GR.
KEGG	cgb:cg1132. cgl:NCgl0953.
PATRIC	21494040. VBICorGlu203724_0977.
Phylogenomic databases
HOGENOM	HBG732538.
OMA	EVYLPLS.
PhylomeDB	Q8NRQ2.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	CGLU196627:CG1132-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_CORGL

Accession

Primary (citable) accession number: Q8NRQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 10, 2002
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program