Reviewed,
UniProtKB/Swiss-Prot Q8NRC3 (ODO1_CORGL)
Last modified
June 16, 2009.
Version 50.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: 2-oxoglutarate dehydrogenase E1 component EC=1.2.4.2 Alternative name(s): Alpha-ketoglutarate dehydrogenase | ||||
| Gene names |
| ||||
| Organism | Corynebacterium glutamicum (Brevibacterium flavum) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1718 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium |
Protein attributes
| Sequence length | 1257 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. UniProtKB P0AFG3 |
| Catalytic activity | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. Ref.1 |
| Cofactor | Thiamine pyrophosphate By similarity. UniProtKB P0AFG3 |
| Enzyme regulation | Inhibited by unphosphorylated odhI, but not by phosphorylated odhI. Ref.4 |
| Subunit structure | Homodimer By similarity. UniProtKB P0AFG3 |
| Sequence similarities | Belongs to the alpha-ketoglutarate dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Ligand | Thiamine pyrophosphate |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | acyltransferase activity Inferred from electronic annotation. Source: InterPro oxoglutarate dehydrogenase (succinyl-transferring) activityInferred from electronic annotation. Source: EC thiamin pyrophosphate bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1257 | 1257 | 2-oxoglutarate dehydrogenase E1 component | PRO_0000273521 | |||||
Experimental info | |||||||||
| Sequence conflict | 20 | 1 | T → I in BAA12222. Ref.1 | ||||||
| Sequence conflict | 80 | 1 | T → A in BAA12222. Ref.1 | ||||||
| Sequence conflict | 118 | 1 | D → A in BAA12222. Ref.1 | ||||||
| Sequence conflict | 274 | 1 | A → T in BAA12222. Ref.1 | ||||||
| Sequence conflict | 449 | 1 | N → S in BAA12222. Ref.1 | ||||||
| Sequence conflict | 460 | 1 | N → S in BAA12222. Ref.1 | ||||||
| Sequence conflict | 1003 | 1 | I → V in BAA12222. Ref.1 | ||||||
| Sequence conflict | 1129 | 1 | N → D in BAA12222. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning of the Corynebacterium glutamicum ('Brevibacterium lactofermentum' AJ12036) odhA gene encoding a novel type of 2-oxoglutarate dehydrogenase." Usuda Y., Tujimoto N., Abe C., Asakura Y., Kimura E., Kawahara Y., Kurahashi O., Matsui H. Microbiology 142:3347-3354(1996) [PubMed: 9004499] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY. Strain: AJ12036. |
| [2] | "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins." Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B.  Tauch A.J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025. |
| [3] | "Complete genomic sequence of Corynebacterium glutamicum ATCC 13032." Nakagawa S. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025. |
| [4] | "Corynebacterial protein kinase G controls 2-oxoglutarate dehydrogenase activity via the phosphorylation status of the OdhI protein." Niebisch A., Kabus A., Schultz C., Weil B., Bott M. J. Biol. Chem. 281:12300-12307(2006) [PubMed: 16522631] [Abstract] Cited for: INHIBITION BY ODHI. |
Cross-references
Sequence databases | |
|---|---|
| D84102 Genomic DNA. Translation: BAA12222.2. Different initiation. BX927151 Genomic DNA. Translation: CAF19835.1. BA000036 Genomic DNA. Translation: BAB98522.1. | |
| RefSeq | NP_600357.3. YP_225421.2. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1E2O based on UniProtKB P07016. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1019114. 3343144. |
| GenomeReviews | Gene locus Cgl1129 in contig BA000036_GR. Gene locus cg1280 in contig BX927147_GR. |
| KEGG | cgb:cg1280. cgl:NCgl1084. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q8NRC3. |
| OMA | Q8NRC3. EGDEPAF. |
Enzyme and pathway databases | |
| BioCyc | CGLU196627-1:CG1280-MON. |
| BRENDA | 1.2.4.2. 812. |
Family and domain databases | |
| InterPro | IPR001078. 2-oxoacid_DH_actylTfrase. IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR005475. Transketolase_central-reg. [Graphical view] |
| PANTHER | PTHR23152. 2oxoglutarate_DH_E1. 1 hit. |
| Pfam | PF00198. 2-oxoacid_dh. 1 hit. PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view] |
| PIRSF | PIRSF000157. Oxoglu_dh_E1. 1 hit. |
| ProDom | PD001115. 2Oxoacid_dh. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00239. 2oxo_dh_E1. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ODO1_CORGL | ||||||||
| Accession | Primary (citable) accession number: Q8NRC3 Secondary accession number(s): P96746, Q6M641 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
