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Q8NQM1

- NADK_CORGL

UniProt

Q8NQM1 - NADK_CORGL

Protein

NAD kinase

Gene

nadK

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei55 – 551Proton acceptorUniRule annotation
    Binding sitei60 – 601NADUniRule annotation
    Binding sitei160 – 1601NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi55 – 562NADUniRule annotation
    Nucleotide bindingi130 – 1312NADUniRule annotation
    Nucleotide bindingi171 – 1766NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Cgl1413, cg1601
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291NAD kinasePRO_0000120614Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi196627.cg1601.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NQM1.
    SMRiQ8NQM1. Positions 3-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227223.
    KOiK00858.
    OMAiGVLWCDG.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8NQM1-1 [UniParc]FASTAAdd to Basket

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    MAAKLLDDAG IDVRVLINDA DDPIAEHSVL GRFTHVRHAA DAADGAELVL    50
    VLGGDGTFLR AADMAHAVDL PVLGINLGHV GFLAEWESDS LEEALKRVID 100
    RDYRIEDRMT LTVVVLDGGG EEIGRGWALN EVSIENLNRR GVLDATLEVD 150
    ARPVASFGCD GVLISTPTGS TAYAFSAGGP VLWPELDAIL VVPNNAHALF 200
    TKPLVVSPKS TVAVESNSDT SAAMAVMDGF RPIPMPPGSR VEVTRGERPV 250
    RWVRLDSSPF TDRLVSKLRL PVTGWRGPQK QAENKDPRSA G 291
    Length:291
    Mass (Da):31,155
    Last modified:October 1, 2002 - v1
    Checksum:i9F31F00986F19573
    GO

    Sequence cautioni

    The sequence CAF21423.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB98806.1.
    BX927152 Genomic DNA. Translation: CAF21423.1. Different initiation.
    RefSeqiNP_600631.1. NC_003450.3.
    YP_225699.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB98806; BAB98806; BAB98806.
    CAF21423; CAF21423; cg1601.
    GeneIDi1019388.
    KEGGicgb:cg1601.
    cgl:NCgl1358.
    PATRICi21494869. VBICorGlu203724_1381.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB98806.1 .
    BX927152 Genomic DNA. Translation: CAF21423.1 . Different initiation.
    RefSeqi NP_600631.1. NC_003450.3.
    YP_225699.1. NC_006958.1.

    3D structure databases

    ProteinModelPortali Q8NQM1.
    SMRi Q8NQM1. Positions 3-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg1601.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB98806 ; BAB98806 ; BAB98806 .
    CAF21423 ; CAF21423 ; cg1601 .
    GeneIDi 1019388.
    KEGGi cgb:cg1601.
    cgl:NCgl1358.
    PATRICi 21494869. VBICorGlu203724_1381.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227223.
    KOi K00858.
    OMAi GVLWCDG.
    OrthoDBi EOG6PZXDR.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiNADK_CORGL
    AccessioniPrimary (citable) accession number: Q8NQM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3