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Q8NQM1

- NADK_CORGL

UniProt

Q8NQM1 - NADK_CORGL

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Protein

NAD kinase

Gene

nadK

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551Proton acceptorUniRule annotation
Binding sitei60 – 601NADUniRule annotation
Binding sitei160 – 1601NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi55 – 562NADUniRule annotation
Nucleotide bindingi130 – 1312NADUniRule annotation
Nucleotide bindingi171 – 1766NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Cgl1413, cg1601
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291NAD kinasePRO_0000120614Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196627.cg1601.

Structurei

3D structure databases

ProteinModelPortaliQ8NQM1.
SMRiQ8NQM1. Positions 3-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227223.
KOiK00858.
OMAiGVLWCDG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NQM1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAKLLDDAG IDVRVLINDA DDPIAEHSVL GRFTHVRHAA DAADGAELVL
60 70 80 90 100
VLGGDGTFLR AADMAHAVDL PVLGINLGHV GFLAEWESDS LEEALKRVID
110 120 130 140 150
RDYRIEDRMT LTVVVLDGGG EEIGRGWALN EVSIENLNRR GVLDATLEVD
160 170 180 190 200
ARPVASFGCD GVLISTPTGS TAYAFSAGGP VLWPELDAIL VVPNNAHALF
210 220 230 240 250
TKPLVVSPKS TVAVESNSDT SAAMAVMDGF RPIPMPPGSR VEVTRGERPV
260 270 280 290
RWVRLDSSPF TDRLVSKLRL PVTGWRGPQK QAENKDPRSA G
Length:291
Mass (Da):31,155
Last modified:October 1, 2002 - v1
Checksum:i9F31F00986F19573
GO

Sequence cautioni

The sequence CAF21423.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB98806.1.
BX927152 Genomic DNA. Translation: CAF21423.1. Different initiation.
RefSeqiNP_600631.1. NC_003450.3.
YP_225699.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98806; BAB98806; BAB98806.
CAF21423; CAF21423; cg1601.
GeneIDi1019388.
3342543.
KEGGicgl:NCgl1358.
PATRICi21494869. VBICorGlu203724_1381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB98806.1 .
BX927152 Genomic DNA. Translation: CAF21423.1 . Different initiation.
RefSeqi NP_600631.1. NC_003450.3.
YP_225699.1. NC_006958.1.

3D structure databases

ProteinModelPortali Q8NQM1.
SMRi Q8NQM1. Positions 3-277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg1601.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB98806 ; BAB98806 ; BAB98806 .
CAF21423 ; CAF21423 ; cg1601 .
GeneIDi 1019388.
3342543.
KEGGi cgl:NCgl1358.
PATRICi 21494869. VBICorGlu203724_1381.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227223.
KOi K00858.
OMAi GVLWCDG.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiNADK_CORGL
AccessioniPrimary (citable) accession number: Q8NQM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3