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Protein

Oxoglutarate dehydrogenase inhibitor

Gene

odhI

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

An essential component of the PknG signaling pathway. When unphosphorylated, it inhibits the activity of 2-oxoglutarate dehydrogenase. When phosphorylated it does not inhibit 2-oxoglutarate dehydrogenase.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Oxoglutarate dehydrogenase inhibitor
Gene namesi
Name:odhI
Ordered Locus Names:Cgl1441, cg1630
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi14 – 141T → A: Inhibition of growth on glutamine and glutamate degradation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 143142Oxoglutarate dehydrogenase inhibitorPRO_0000272962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8NQJ3.

2D gel databases

World-2DPAGE0001:Q8NQJ3.

PTM databases

iPTMnetiQ8NQJ3.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
odhAQ8NRC32EBI-7868645,EBI-7868591

Protein-protein interaction databases

DIPiDIP-48322N.
IntActiQ8NQJ3. 1 interaction.
MINTiMINT-7713247.
STRINGi196627.cg1630.

Structurei

Secondary structure

1
143
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 287Combined sources
Beta strandi35 – 384Combined sources
Turni39 – 413Combined sources
Beta strandi43 – 453Combined sources
Beta strandi47 – 548Combined sources
Turni55 – 584Combined sources
Beta strandi60 – 634Combined sources
Beta strandi65 – 739Combined sources
Beta strandi77 – 793Combined sources
Beta strandi82 – 843Combined sources
Beta strandi90 – 978Combined sources
Beta strandi99 – 1035Combined sources
Beta strandi110 – 1123Combined sources
Beta strandi118 – 1214Combined sources
Beta strandi127 – 1304Combined sources
Beta strandi133 – 1397Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KB3NMR-A1-143[»]
2KB4NMR-A1-143[»]
4QCJX-ray2.00A1-143[»]
ProteinModelPortaliQ8NQJ3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NQJ3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 11750FHAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108UW8. Bacteria.
COG1716. LUCA.
HOGENOMiHOG000242873.
OMAiFRLVFLN.
OrthoDBiEOG6SR96T.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NQJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNNGTPEP QVETTSVFRA DLLKEMESST GTAPASTGAE NLPAGSALLV
60 70 80 90 100
VKRGPNAGAR FLLDQPTTTA GRHPESDIFL DDVTVSRRHA EFRINEGEFE
110 120 130 140
VVDVGSLNGT YVNREPRNAQ VMQTGDEIQI GKFRLVFLAG PAE
Length:143
Mass (Da):15,402
Last modified:October 1, 2002 - v1
Checksum:i1AFFC8459842FCDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB98834.1.
BX927152 Genomic DNA. Translation: CAF21450.1.
RefSeqiNP_600658.1. NC_003450.3.
WP_003856253.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98834; BAB98834; BAB98834.
CAF21450; CAF21450; cg1630.
GeneIDi1019415.
KEGGicgb:cg1630.
cgl:NCgl1385.
PATRICi21494925. VBICorGlu203724_1408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB98834.1.
BX927152 Genomic DNA. Translation: CAF21450.1.
RefSeqiNP_600658.1. NC_003450.3.
WP_003856253.1. NC_006958.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KB3NMR-A1-143[»]
2KB4NMR-A1-143[»]
4QCJX-ray2.00A1-143[»]
ProteinModelPortaliQ8NQJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48322N.
IntActiQ8NQJ3. 1 interaction.
MINTiMINT-7713247.
STRINGi196627.cg1630.

PTM databases

iPTMnetiQ8NQJ3.

2D gel databases

World-2DPAGE0001:Q8NQJ3.

Proteomic databases

PRIDEiQ8NQJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB98834; BAB98834; BAB98834.
CAF21450; CAF21450; cg1630.
GeneIDi1019415.
KEGGicgb:cg1630.
cgl:NCgl1385.
PATRICi21494925. VBICorGlu203724_1408.

Phylogenomic databases

eggNOGiENOG4108UW8. Bacteria.
COG1716. LUCA.
HOGENOMiHOG000242873.
OMAiFRLVFLN.
OrthoDBiEOG6SR96T.

Miscellaneous databases

EvolutionaryTraceiQ8NQJ3.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025Imported.
  3. "Corynebacterial protein kinase G controls 2-oxoglutarate dehydrogenase activity via the phosphorylation status of the OdhI protein."
    Niebisch A., Kabus A., Schultz C., Weil B., Bott M.
    J. Biol. Chem. 281:12300-12307(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-19, IDENTIFICATION, FUNCTION, PHOSPHORYLATION AT THR-14, MUTAGENESIS OF THR-14.
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 100251 Publication.

Entry informationi

Entry nameiODHI_CORGL
AccessioniPrimary (citable) accession number: Q8NQJ3
Secondary accession number(s): Q6M5D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 1, 2002
Last modified: January 20, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.