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Protein

Oxoglutarate dehydrogenase inhibitor

Gene

odhI

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

An essential component of the PknG signaling pathway. When unphosphorylated, it inhibits the activity of 2-oxoglutarate dehydrogenase. When phosphorylated it does not inhibit 2-oxoglutarate dehydrogenase.1 Publication

Enzyme and pathway databases

BioCyciCORYNE:G18NG-11024-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxoglutarate dehydrogenase inhibitor
Gene namesi
Name:odhI
Ordered Locus Names:Cgl1441, cg1630
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi14T → A: Inhibition of growth on glutamine and glutamate degradation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002729622 – 143Oxoglutarate dehydrogenase inhibitorAdd BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8NQJ3.

2D gel databases

World-2DPAGE0001:Q8NQJ3.

PTM databases

iPTMnetiQ8NQJ3.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
odhAQ8NRC32EBI-7868645,EBI-7868591

Protein-protein interaction databases

DIPiDIP-48322N.
IntActiQ8NQJ3. 1 interactor.
MINTiMINT-7713247.
STRINGi196627.cg1630.

Structurei

Secondary structure

1143
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi22 – 28Combined sources7
Beta strandi35 – 38Combined sources4
Turni39 – 41Combined sources3
Beta strandi43 – 45Combined sources3
Beta strandi47 – 54Combined sources8
Turni55 – 58Combined sources4
Beta strandi60 – 63Combined sources4
Beta strandi65 – 73Combined sources9
Beta strandi77 – 79Combined sources3
Beta strandi82 – 84Combined sources3
Beta strandi90 – 97Combined sources8
Beta strandi99 – 103Combined sources5
Beta strandi110 – 112Combined sources3
Beta strandi118 – 121Combined sources4
Beta strandi127 – 130Combined sources4
Beta strandi133 – 139Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KB3NMR-A1-143[»]
2KB4NMR-A1-143[»]
4QCJX-ray2.00A1-143[»]
ProteinModelPortaliQ8NQJ3.
SMRiQ8NQJ3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NQJ3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 117FHAPROSITE-ProRule annotationAdd BLAST50

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108UW8. Bacteria.
COG1716. LUCA.
HOGENOMiHOG000242873.
OMAiNREPVDT.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NQJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNNGTPEP QVETTSVFRA DLLKEMESST GTAPASTGAE NLPAGSALLV
60 70 80 90 100
VKRGPNAGAR FLLDQPTTTA GRHPESDIFL DDVTVSRRHA EFRINEGEFE
110 120 130 140
VVDVGSLNGT YVNREPRNAQ VMQTGDEIQI GKFRLVFLAG PAE
Length:143
Mass (Da):15,402
Last modified:October 1, 2002 - v1
Checksum:i1AFFC8459842FCDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB98834.1.
BX927152 Genomic DNA. Translation: CAF21450.1.
RefSeqiNP_600658.1. NC_003450.3.
WP_003856253.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98834; BAB98834; BAB98834.
CAF21450; CAF21450; cg1630.
GeneIDi1019415.
KEGGicgb:cg1630.
cgl:NCgl1385.
PATRICi21494925. VBICorGlu203724_1408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB98834.1.
BX927152 Genomic DNA. Translation: CAF21450.1.
RefSeqiNP_600658.1. NC_003450.3.
WP_003856253.1. NC_006958.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KB3NMR-A1-143[»]
2KB4NMR-A1-143[»]
4QCJX-ray2.00A1-143[»]
ProteinModelPortaliQ8NQJ3.
SMRiQ8NQJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48322N.
IntActiQ8NQJ3. 1 interactor.
MINTiMINT-7713247.
STRINGi196627.cg1630.

PTM databases

iPTMnetiQ8NQJ3.

2D gel databases

World-2DPAGE0001:Q8NQJ3.

Proteomic databases

PRIDEiQ8NQJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB98834; BAB98834; BAB98834.
CAF21450; CAF21450; cg1630.
GeneIDi1019415.
KEGGicgb:cg1630.
cgl:NCgl1385.
PATRICi21494925. VBICorGlu203724_1408.

Phylogenomic databases

eggNOGiENOG4108UW8. Bacteria.
COG1716. LUCA.
HOGENOMiHOG000242873.
OMAiNREPVDT.

Enzyme and pathway databases

BioCyciCORYNE:G18NG-11024-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8NQJ3.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiODHI_CORGL
AccessioniPrimary (citable) accession number: Q8NQJ3
Secondary accession number(s): Q6M5D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.