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Q8NQI2 (Q8NQI2_CORGL) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating RuleBase RU000485 PIRNR PIRNR000109
EC=1.1.1.44 RuleBase RU000485 PIRNR PIRNR000109
Gene names
Name:gnd EMBL CAF21461.1
Ordered Locus Names:cg1643, Cgl1452
OrganismCorynebacterium glutamicum (Brevibacterium flavum)
Taxonomic identifier1718 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. RuleBase RU000485 PIRNR PIRNR000109

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. RuleBase RU000485 PIRNR PIRNR000109

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding22 – 276NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding45 – 473NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding87 – 893NADP By similarity PIRSR PIRSR000109-3
Region141 – 1433Substrate binding By similarity PIRSR PIRSR000109-2
Region198 – 1992Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1951Proton acceptor By similarity PIRSR PIRSR000109-1
Active site2021Proton donor By similarity PIRSR PIRSR000109-1
Binding site1151NADP By similarity PIRSR PIRSR000109-3
Binding site1151Substrate By similarity PIRSR PIRSR000109-2
Binding site2031Substrate By similarity PIRSR PIRSR000109-2
Binding site2731Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site3001Substrate By similarity PIRSR PIRSR000109-2
Binding site4621Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4681Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q8NQI2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 6F3C426D721D5769

FASTA49252,579
        10         20         30         40         50         60 
MPSSTINNMT NGDNLAQIGV VGLAVMGSNL ARNFARNGNT VAVYNRSTDK TDKLIADHGS 

        70         80         90        100        110        120 
EGNFIPSATV EEFVASLEKP RRAIIMVQAG NATDAVINQL ADAMDEGDII IDGGNALYTD 

       130        140        150        160        170        180 
TIRREKEISA RGLHFVGAGI SGGEEGALNG PSIMPGGPAK SYESLGPLLE SIAANVDGTP 

       190        200        210        220        230        240 
CVTHIGPDGA GHFVKMVHNG IEYADMQVIG EAYHLLRYAA GMQPAEIAEV FKEWNAGDLD 

       250        260        270        280        290        300 
SYLIEITAEV LSQVDAETGK PLIDVIVDAA GQKGTGRWTV KAALDLGIAT TGIGEAVFAR 

       310        320        330        340        350        360 
ALSGATSQRA AAQGNLPAGV LTDLEALGVD KAQFVEDVRR ALYASKLVAY AQGFDEIKAG 

       370        380        390        400        410        420 
SDENNWDVDP RDLATIWRGG CIIRAKFLNR IVEAYDANAE LESLLLDPYF KSELGDLIDS 

       430        440        450        460        470        480 
WRRVIVTATQ LGLPIPVFAS SLSYYDSLRA ERLPAALIQG QRDFFGAHTY KRIDKDGSFH 

       490 
TEWSGDRSEV EA

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References

[1]"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins."
Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. expand/collapse author list , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.
J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025 [Kalinowski].
[2]"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032."
Nakagawa S.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025 [Nakagawa].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000036 Genomic DNA. Translation: BAB98845.1.
BX927152 Genomic DNA. Translation: CAF21461.1.
RefSeqNP_600669.1. NC_003450.3.
YP_225737.1. NC_006958.1.

3D structure databases

HSSPHSSP built from PDB template 2PGD based on UniProtKB P00349.
ProteinModelPortalQ8NQI2.
SMRQ8NQI2. Positions 16-484.
ModBaseSearch...

2D gel databases

World-2DPAGE0001:Q8NQI2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1019426.
3344993.
GenomeReviewsGene locus Cgl1452 in contig BA000036_GR.
Gene locus cg1643 in contig BX927147_GR.
KEGGcgb:cg1643.
cgl:NCgl1396.
PATRIC21494947. VBICorGlu203724_1419.

Phylogenomic databases

HOGENOMHBG286913.
OMASNYPDTN.
PhylomeDBQ8NQI2.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8NQI2_CORGL
AccessionPrimary (citable) accession number: Q8NQI2
Secondary accession number(s): Q6M5C8
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info