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Q8NQC3 (UPPP_CORGL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:Cgl1515, cg1710
OrganismCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) [Reference proteome] [HAMAP]
Taxonomic identifier196627 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence caution

The sequence CAF21524.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151140

Regions

Transmembrane74 – 9421Helical; Potential
Transmembrane107 – 12721Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane209 – 22921Helical; Potential
Transmembrane243 – 26321Helical; Potential
Transmembrane271 – 29121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8NQC3 [UniParc].

Last modified October 10, 2002. Version 1.
Checksum: 8FCD9F77D16D136E

FASTA29331,578
        10         20         30         40         50         60 
MNEEITLLAA AADPAATENI GWVQTIVLSI VQGLTEFLPI SSSGHLRIIS ELFWGADAGA 

        70         80         90        100        110        120 
SFTAVVQLGT EAAVLVFFAK EIWQIITGWF AGVFNKERRG FEYRMGWMII VATIPVVILG 

       130        140        150        160        170        180 
VLGKDLIREA LRNMWITASV LILFSLVFIL AEKMGKKERD YDKLTMKDAI IMGLAQCLAL 

       190        200        210        220        230        240 
IPGVSRSGGT ISAGLFLGLK REVATKFSFL LAIPAVLGSG LYSLPDAFAP SSGQAASGLQ 

       250        260        270        280        290 
LTVGTLVAFV VGYISIAWLM KFVANHSFSW FAAYRIPAGL LVMLLLALGM LNP 

« Hide

References

[1]"The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
Ikeda M., Nakagawa S.
Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[2]"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins."
Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. expand/collapse author list , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.
J. Biotechnol. 104:5-25(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000036 Genomic DNA. Translation: BAB98908.1.
BX927152 Genomic DNA. Translation: CAF21524.1. Different initiation.
RefSeqNP_600731.1. NC_003450.3.
YP_225800.2. NC_006958.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196627.cg1710.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB98908; BAB98908; BAB98908.
CAF21524; CAF21524; cg1710.
GeneID1019488.
KEGGcgb:cg1710.
cgl:NCgl1458.
PATRIC21495075. VBICorGlu203724_1483.

Phylogenomic databases

eggNOGCOG1968.
KOK06153.
OMAIEGPFRD.
OrthoDBEOG6QP13M.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_CORGL
AccessionPrimary (citable) accession number: Q8NQC3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families