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Q8NQC3

- UPPP_CORGL

UniProt

Q8NQC3 - UPPP_CORGL

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (10 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA, upk
    Ordered Locus Names:Cgl1515, cg1710
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 293293Undecaprenyl-diphosphatasePRO_0000151140Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi196627.cg1710.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei74 – 9421HelicalUniRule annotationAdd
    BLAST
    Transmembranei107 – 12721HelicalUniRule annotationAdd
    BLAST
    Transmembranei134 – 15421HelicalUniRule annotationAdd
    BLAST
    Transmembranei209 – 22921HelicalUniRule annotationAdd
    BLAST
    Transmembranei243 – 26321HelicalUniRule annotationAdd
    BLAST
    Transmembranei271 – 29121HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    KOiK06153.
    OMAiIEGPFRD.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8NQC3-1 [UniParc]FASTAAdd to Basket

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    MNEEITLLAA AADPAATENI GWVQTIVLSI VQGLTEFLPI SSSGHLRIIS    50
    ELFWGADAGA SFTAVVQLGT EAAVLVFFAK EIWQIITGWF AGVFNKERRG 100
    FEYRMGWMII VATIPVVILG VLGKDLIREA LRNMWITASV LILFSLVFIL 150
    AEKMGKKERD YDKLTMKDAI IMGLAQCLAL IPGVSRSGGT ISAGLFLGLK 200
    REVATKFSFL LAIPAVLGSG LYSLPDAFAP SSGQAASGLQ LTVGTLVAFV 250
    VGYISIAWLM KFVANHSFSW FAAYRIPAGL LVMLLLALGM LNP 293
    Length:293
    Mass (Da):31,578
    Last modified:October 10, 2002 - v1
    Checksum:i8FCD9F77D16D136E
    GO

    Sequence cautioni

    The sequence CAF21524.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB98908.1.
    BX927152 Genomic DNA. Translation: CAF21524.1. Different initiation.
    RefSeqiNP_600731.1. NC_003450.3.
    YP_225800.2. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB98908; BAB98908; BAB98908.
    CAF21524; CAF21524; cg1710.
    GeneIDi1019488.
    KEGGicgb:cg1710.
    cgl:NCgl1458.
    PATRICi21495075. VBICorGlu203724_1483.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB98908.1 .
    BX927152 Genomic DNA. Translation: CAF21524.1 . Different initiation.
    RefSeqi NP_600731.1. NC_003450.3.
    YP_225800.2. NC_006958.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg1710.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB98908 ; BAB98908 ; BAB98908 .
    CAF21524 ; CAF21524 ; cg1710 .
    GeneIDi 1019488.
    KEGGi cgb:cg1710.
    cgl:NCgl1458.
    PATRICi 21495075. VBICorGlu203724_1483.

    Phylogenomic databases

    eggNOGi COG1968.
    KOi K06153.
    OMAi IEGPFRD.
    OrthoDBi EOG6QP13M.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiUPPP_CORGL
    AccessioniPrimary (citable) accession number: Q8NQC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: October 10, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3