Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NQ97

- ACNR_CORGL

UniProt

Q8NQ97 - ACNR_CORGL

Protein

HTH-type transcriptional repressor AcnR

Gene

acnR

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Represses the aconitase gene acn. Binds to the imperfect inverted repeat 5'-AGAACGCTTGTACTG-3' in the acn promoter region.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi33 – 5220H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional repressor AcnR
    Gene namesi
    Name:acnR
    Ordered Locus Names:Cgl1541, cg1738
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 188188HTH-type transcriptional repressor AcnRPRO_0000070571Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi196627.cg1738.

    Structurei

    Secondary structure

    1
    188
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi12 – 3120
    Helixi34 – 418
    Helixi45 – 528
    Helixi55 – 8834
    Helixi90 – 923
    Helixi93 – 1019
    Helixi103 – 1086
    Helixi110 – 11910
    Helixi121 – 13616
    Beta strandi142 – 1443
    Helixi146 – 16520
    Helixi173 – 18412

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AC6X-ray2.54A2-188[»]
    4ACIX-ray1.65A/B2-188[»]
    4AF5X-ray1.90A1-188[»]
    ProteinModelPortaliQ8NQ97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 7061HTH tetR-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1309.
    HOGENOMiHOG000248228.
    OMAiQGLVQVM.
    OrthoDBiEOG6ZKXQV.

    Family and domain databases

    Gene3Di1.10.357.10. 1 hit.
    InterProiIPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view]
    PfamiPF00440. TetR_N. 1 hit.
    [Graphical view]
    PRINTSiPR00455. HTHTETR.
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEiPS50977. HTH_TETR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NQ97-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVAAGDKPT NSRQEILEGA RRCFAEHGYE GATVRRLEEA TGKSRGAIFH    50
    HFGDKENLFL ALAREDAARM AEVVSENGLV EVMRGMLEDP ERYDWMSVRL 100
    EISKQLRTDP VFRAKWIDHQ SVLDEAVRVR LSRNVDKGQM RTDVPIEVLH 150
    TFLETVLDGF ISRLATGAST EGLSEVLDLV EGTVRKRD 188
    Length:188
    Mass (Da):21,185
    Last modified:October 1, 2002 - v1
    Checksum:i54F31FA9A184B836
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB98934.1.
    BX927152 Genomic DNA. Translation: CAF21549.1.
    RefSeqiNP_600756.1. NC_003450.3.
    YP_225825.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB98934; BAB98934; BAB98934.
    CAF21549; CAF21549; cg1738.
    GeneIDi1019513.
    KEGGicgb:cg1738.
    cgl:NCgl1483.
    PATRICi21495129. VBICorGlu203724_1508.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB98934.1 .
    BX927152 Genomic DNA. Translation: CAF21549.1 .
    RefSeqi NP_600756.1. NC_003450.3.
    YP_225825.1. NC_006958.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AC6 X-ray 2.54 A 2-188 [» ]
    4ACI X-ray 1.65 A/B 2-188 [» ]
    4AF5 X-ray 1.90 A 1-188 [» ]
    ProteinModelPortali Q8NQ97.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg1738.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB98934 ; BAB98934 ; BAB98934 .
    CAF21549 ; CAF21549 ; cg1738 .
    GeneIDi 1019513.
    KEGGi cgb:cg1738.
    cgl:NCgl1483.
    PATRICi 21495129. VBICorGlu203724_1508.

    Phylogenomic databases

    eggNOGi COG1309.
    HOGENOMi HOG000248228.
    OMAi QGLVQVM.
    OrthoDBi EOG6ZKXQV.

    Family and domain databases

    Gene3Di 1.10.357.10. 1 hit.
    InterProi IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view ]
    Pfami PF00440. TetR_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00455. HTHTETR.
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEi PS50977. HTH_TETR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    3. "Identification of AcnR, a TetR-type repressor of the aconitase gene acn in Corynebacterium glutamicum."
      Krug A., Wendisch V.F., Bott M.
      J. Biol. Chem. 280:585-595(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiACNR_CORGL
    AccessioniPrimary (citable) accession number: Q8NQ97
    Secondary accession number(s): Q6M549
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Deletion of acnR leads to 5-fold increased aconitase activity. Overexpression of acnR leads to a 2-fold decreased aconitase activity.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3