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Q8NQ97 (ACNR_CORGL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HTH-type transcriptional repressor AcnR
Gene names
Name:acnR
Ordered Locus Names:Cgl1541, cg1738
OrganismCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) [Reference proteome] [HAMAP]
Taxonomic identifier196627 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Represses the aconitase gene acn. Binds to the imperfect inverted repeat 5'-AGAACGCTTGTACTG-3' in the acn promoter region.

Subunit structure

Homodimer.

Miscellaneous

Deletion of acnR leads to 5-fold increased aconitase activity. Overexpression of acnR leads to a 2-fold decreased aconitase activity.

Sequence similarities

Contains 1 HTH tetR-type DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   LigandDNA-binding
   Molecular functionRepressor
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 188188HTH-type transcriptional repressor AcnR
PRO_0000070571

Regions

Domain10 – 7061HTH tetR-type
DNA binding33 – 5220H-T-H motif Potential

Secondary structure

........................ 188
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8NQ97 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 54F31FA9A184B836

FASTA18821,185
        10         20         30         40         50         60 
MSVAAGDKPT NSRQEILEGA RRCFAEHGYE GATVRRLEEA TGKSRGAIFH HFGDKENLFL 

        70         80         90        100        110        120 
ALAREDAARM AEVVSENGLV EVMRGMLEDP ERYDWMSVRL EISKQLRTDP VFRAKWIDHQ 

       130        140        150        160        170        180 
SVLDEAVRVR LSRNVDKGQM RTDVPIEVLH TFLETVLDGF ISRLATGAST EGLSEVLDLV 


EGTVRKRD 

« Hide

References

« Hide 'large scale' references
[1]"The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
Ikeda M., Nakagawa S.
Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[2]"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins."
Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. expand/collapse author list , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.
J. Biotechnol. 104:5-25(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[3]"Identification of AcnR, a TetR-type repressor of the aconitase gene acn in Corynebacterium glutamicum."
Krug A., Wendisch V.F., Bott M.
J. Biol. Chem. 280:585-595(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000036 Genomic DNA. Translation: BAB98934.1.
BX927152 Genomic DNA. Translation: CAF21549.1.
RefSeqNP_600756.1. NC_003450.3.
YP_225825.1. NC_006958.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4AC6X-ray2.54A2-188[»]
4ACIX-ray1.65A/B2-188[»]
4AF5X-ray1.90A1-188[»]
ProteinModelPortalQ8NQ97.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196627.cg1738.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB98934; BAB98934; BAB98934.
CAF21549; CAF21549; cg1738.
GeneID1019513.
3344470.
KEGGcgb:cg1738.
cgl:NCgl1483.
PATRIC21495129. VBICorGlu203724_1508.

Phylogenomic databases

eggNOGCOG1309.
HOGENOMHOG000248228.
OMAAIFHHFG.
OrthoDBEOG6ZKXQV.
ProtClustDBCLSK871936.

Family and domain databases

Gene3D1.10.357.10. 1 hit.
InterProIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSPR00455. HTHTETR.
SUPFAMSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACNR_CORGL
AccessionPrimary (citable) accession number: Q8NQ97
Secondary accession number(s): Q6M549
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references