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Q8NQ97

- ACNR_CORGL

UniProt

Q8NQ97 - ACNR_CORGL

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Protein
HTH-type transcriptional repressor AcnR
Gene
acnR, Cgl1541, cg1738
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Represses the aconitase gene acn. Binds to the imperfect inverted repeat 5'-AGAACGCTTGTACTG-3' in the acn promoter region.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi33 – 5220H-T-H motif Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor AcnR
Gene namesi
Name:acnR
Ordered Locus Names:Cgl1541, cg1738
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188HTH-type transcriptional repressor AcnR
PRO_0000070571Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi196627.cg1738.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi12 – 3120
Helixi34 – 418
Helixi45 – 528
Helixi55 – 8834
Helixi90 – 923
Helixi93 – 1019
Helixi103 – 1086
Helixi110 – 11910
Helixi121 – 13616
Beta strandi142 – 1443
Helixi146 – 16520
Helixi173 – 18412

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AC6X-ray2.54A2-188[»]
4ACIX-ray1.65A/B2-188[»]
4AF5X-ray1.90A1-188[»]
ProteinModelPortaliQ8NQ97.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 7061HTH tetR-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1309.
HOGENOMiHOG000248228.
OMAiQGLVQVM.
OrthoDBiEOG6ZKXQV.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NQ97-1 [UniParc]FASTAAdd to Basket

« Hide

MSVAAGDKPT NSRQEILEGA RRCFAEHGYE GATVRRLEEA TGKSRGAIFH    50
HFGDKENLFL ALAREDAARM AEVVSENGLV EVMRGMLEDP ERYDWMSVRL 100
EISKQLRTDP VFRAKWIDHQ SVLDEAVRVR LSRNVDKGQM RTDVPIEVLH 150
TFLETVLDGF ISRLATGAST EGLSEVLDLV EGTVRKRD 188
Length:188
Mass (Da):21,185
Last modified:October 1, 2002 - v1
Checksum:i54F31FA9A184B836
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000036 Genomic DNA. Translation: BAB98934.1.
BX927152 Genomic DNA. Translation: CAF21549.1.
RefSeqiNP_600756.1. NC_003450.3.
YP_225825.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98934; BAB98934; BAB98934.
CAF21549; CAF21549; cg1738.
GeneIDi1019513.
KEGGicgb:cg1738.
cgl:NCgl1483.
PATRICi21495129. VBICorGlu203724_1508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000036 Genomic DNA. Translation: BAB98934.1 .
BX927152 Genomic DNA. Translation: CAF21549.1 .
RefSeqi NP_600756.1. NC_003450.3.
YP_225825.1. NC_006958.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AC6 X-ray 2.54 A 2-188 [» ]
4ACI X-ray 1.65 A/B 2-188 [» ]
4AF5 X-ray 1.90 A 1-188 [» ]
ProteinModelPortali Q8NQ97.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg1738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB98934 ; BAB98934 ; BAB98934 .
CAF21549 ; CAF21549 ; cg1738 .
GeneIDi 1019513.
KEGGi cgb:cg1738.
cgl:NCgl1483.
PATRICi 21495129. VBICorGlu203724_1508.

Phylogenomic databases

eggNOGi COG1309.
HOGENOMi HOG000248228.
OMAi QGLVQVM.
OrthoDBi EOG6ZKXQV.

Family and domain databases

Gene3Di 1.10.357.10. 1 hit.
InterProi IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view ]
Pfami PF00440. TetR_N. 1 hit.
[Graphical view ]
PRINTSi PR00455. HTHTETR.
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEi PS50977. HTH_TETR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. "Identification of AcnR, a TetR-type repressor of the aconitase gene acn in Corynebacterium glutamicum."
    Krug A., Wendisch V.F., Bott M.
    J. Biol. Chem. 280:585-595(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiACNR_CORGL
AccessioniPrimary (citable) accession number: Q8NQ97
Secondary accession number(s): Q6M549
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Deletion of acnR leads to 5-fold increased aconitase activity. Overexpression of acnR leads to a 2-fold decreased aconitase activity.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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