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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciCORYNE:G18NG-11185-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Cgl1600, cg1803
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829541 – 315Methionyl-tRNA formyltransferaseAdd BLAST315

Interactioni

Protein-protein interaction databases

STRINGi196627.cg1803

Structurei

3D structure databases

ProteinModelPortaliQ8NQ47
SMRiQ8NQ47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni114 – 117Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NQ47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLVFAGTPE PAVVALQKLI DSDHEVVAVL TQPDARRGRG RTLHPSAVAE
60 70 80 90 100
LAQQHGIEVL KPTSLKADTE DGQAIRQRLA ELAPDCLPVV AYGQLITKDL
110 120 130 140 150
LDVAPHGWVN LHFSLLPAWR GAAPVQASIR EGDQITGATT FRIDEGLDTG
160 170 180 190 200
VILSTIEDTI QPTDTADDLL TRLAYSGGDL LVETMTGLEQ GTITPRAQEG
210 220 230 240 250
EATYASKITT QDAQIDWSKP AEVIDRHIRA HTPGPGAWTT LVDARLKVGP
260 270 280 290 300
ISHSGEVEVA ADLAPGAILA QKNSVVVGTG TTPIVLGNIQ PPGKKMMNAA
310
DWARGVQLDQ EAKFQ
Length:315
Mass (Da):33,590
Last modified:October 10, 2002 - v1
Checksum:iFD9148FD05C4B837
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAB98993.1
BX927152 Genomic DNA Translation: CAF21608.1
RefSeqiNP_600814.1, NC_003450.3
WP_003862229.1, NC_006958.1

Genome annotation databases

EnsemblBacteriaiBAB98993; BAB98993; BAB98993
CAF21608; CAF21608; cg1803
GeneIDi1019568
KEGGicgb:cg1803
cgl:NCgl1538
PATRICifig|196627.13.peg.1562

Similar proteinsi

Entry informationi

Entry nameiFMT_CORGL
AccessioniPrimary (citable) accession number: Q8NQ47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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