Q8NQ42 (KGUA_CORGL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Synonyms:	drp113
Ordered Locus Names:	Cgl1606, cg1810

Organism

Corynebacterium glutamicum (Brevibacterium flavum)

Taxonomic identifier

1718 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity HAMAP MF_00328.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.
Sequence caution	The sequence BAB88664.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB98999.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Guanylate kinase HAMAP MF_00328		PRO_0000170529
Regions
	Domain	8 – 188	181	Guanylate kinase-like
	Nucleotide binding	15 – 22	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8NQ42 [UniParc]. Last modified March 15, 2004. Version 2. Checksum: D8BB7079C53FE19A	FASTA	190	20,657
	10 20 30 40 50 60 MSGDNQLGRL VILAGPSAVG KSTVVDRLRN DVPNLYFSVS MTTRAPRPGE VDGRDYFYVT 70 80 90 100 110 120 AQEFQDKIDC GEMLEWADIH GGLQRSGTPA GPVNEARQNG RPVLVEVDLA GARNIASLIP 130 140 150 160 170 180 DAETIFLAPP SWEVLVERLT GRGTESEDVI ARRLETAREE LAAQSEFKHV IINDDVDTAV 190 KAIEDVLLGA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Drp113 of Corynebacterim glutamicum." Hirano S., Kimura E., Kawahara Y., Sugimoto S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032." Nakagawa S. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[3]	"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins." Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A. J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB083048 Genomic DNA. Translation: BAB88664.1. Different initiation. BA000036 Genomic DNA. Translation: BAB98999.1. Different initiation. BX927152 Genomic DNA. Translation: CAF21615.1.
RefSeq	NP_600820.2. NC_003450.3. YP_225891.1. NC_006958.1.
3D structure databases
ProteinModelPortal	Q8NQ42.
SMR	Q8NQ42. Positions 7-189.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1019574. 3343588.
GenomeReviews	Gene locus Cgl1606 in contig BA000036_GR. Gene locus cg1810 in contig BX927147_GR.
KEGG	cgb:cg1810. cgl:NCgl1544.
PATRIC	21495249. VBICorGlu203724_1568.
Phylogenomic databases
HOGENOM	HBG671982.
OMA	EWAEFAG.
PhylomeDB	Q8NQ42.
ProtClustDB	PRK00300.
Enzyme and pathway databases
BioCyc	CGLU196627:CG1810-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
KO	K00942.
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. Guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_CORGL

Accession

Primary (citable) accession number: Q8NQ42
Secondary accession number(s): Q8RQN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	March 15, 2004
Last modified:	January 25, 2012
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program