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Q8NQ40

- PYRF_CORGL

UniProt

Q8NQ40 - PYRF_CORGL

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (10 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei95 – 951Proton donorUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:Cgl1608, cg1812
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Orotidine 5'-phosphate decarboxylasePRO_0000134625Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi196627.cg1812.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NQ40.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000245748.
    KOiK01591.
    OMAiKREIYGP.
    OrthoDBiEOG6DZF33.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01215. OMPdecase_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NQ40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTFGEKLLNA ASTRGRLCVG IDPHESLLTS WGLPVNVDGL AEFSRACVEA    50
    FADTVALVKP QVAFYERFGS AGFAILEETI QTLRERGCLV VSDAKRGDIG 100
    STMAGYASAW LDPASPLSSD AVTVSPYLGF HSLDPVFELA EQHGRGVFVL 150
    AATSNPEARE LQDQQNADGV SISQQIVDQA AALNAPYMAQ GKAGNIGVVI 200
    GATLSKPPRL STLGGAILMP GVGAQGGTAS DVDEIAGDMA HLAFPNVSRS 250
    ILATGPDIAE MKNSVAKNAA DFPGFPRS 278
    Length:278
    Mass (Da):28,920
    Last modified:October 10, 2002 - v1
    Checksum:iC601AF5C822133F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB99001.1.
    BX927152 Genomic DNA. Translation: CAF21617.1.
    RefSeqiNP_600822.1. NC_003450.3.
    YP_225893.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB99001; BAB99001; BAB99001.
    CAF21617; CAF21617; cg1812.
    GeneIDi1019576.
    KEGGicgb:cg1812.
    cgl:NCgl1546.
    PATRICi21495253. VBICorGlu203724_1570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB99001.1 .
    BX927152 Genomic DNA. Translation: CAF21617.1 .
    RefSeqi NP_600822.1. NC_003450.3.
    YP_225893.1. NC_006958.1.

    3D structure databases

    ProteinModelPortali Q8NQ40.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg1812.

    Protocols and materials databases

    DNASUi 3342821.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB99001 ; BAB99001 ; BAB99001 .
    CAF21617 ; CAF21617 ; cg1812 .
    GeneIDi 1019576.
    KEGGi cgb:cg1812.
    cgl:NCgl1546.
    PATRICi 21495253. VBICorGlu203724_1570.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000245748.
    KOi K01591.
    OMAi KREIYGP.
    OrthoDBi EOG6DZF33.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01215. OMPdecase_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiPYRF_CORGL
    AccessioniPrimary (citable) accession number: Q8NQ40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: October 10, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3