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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi543MagnesiumUniRule annotation1
Metal bindingi549MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciCORYNE:G18NG-11567-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Cgl1975, cg2166
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003296091 – 753Polyribonucleotide nucleotidyltransferaseAdd BLAST753

Proteomic databases

PRIDEiQ8NP50

Interactioni

Protein-protein interaction databases

STRINGi196627.cg2166

Structurei

3D structure databases

ProteinModelPortaliQ8NP50
SMRiQ8NP50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini609 – 668KHUniRule annotationAdd BLAST60
Domaini680 – 749S1 motifUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN

Family and domain databases

Gene3Di3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR036345 ExoRNase_PH_dom2_sf
IPR014069 GPSI/PNP
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
TIGR02696 pppGpp_PNP, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NP50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVKYFEDT EFGLIEAVAT IDNGDFGTRT IRFETGQLAR QADGAVTTYL
60 70 80 90 100
DDDTMLLATT TASNQPREGF DFFPLTVDVE ERMYAAGRIP GSFFRREGRP
110 120 130 140 150
STEAILACRL IDRPLRPTFV KGLRNEVQIV VTVMSMNPED YYDVVAINGA
160 170 180 190 200
SAATRISGLP VSGAVGGVRM ALVVDEKHPE GQWVAFPTHA QHEQSVFEIV
210 220 230 240 250
VAGRLVERKR GNKTFSDVAV MMVEAGASEN VVNRVKDGAP APTEKIVSDG
260 270 280 290 300
LEAAKPFIDI LCRAQEGLAQ RVGNAAKEFP LFPPYTDEVY SAVERKVSKK
310 320 330 340 350
LASLLTLKAK QERDDATNAY MEEIEAELLP KFEASYSSAA EASKEIRAGY
360 370 380 390 400
NAVMKAIVRR MILTDHFRID GRGVTDIRDL AVEVELIPRA HGSSLFERGE
410 420 430 440 450
TQILGVTTLD MLKMEQQIDS LAPGDAKRYM HHYNFPPYST GETGRVGSPK
460 470 480 490 500
RREIGHGALA ERAVLPVIPS REEFPYAIRQ VSEALGSNGS TSMGSVCAST
510 520 530 540 550
LSLYNAGVPL KAPVAGIAMG LVSGEIDGKT EYVALTDILG AEDAFGDMDF
560 570 580 590 600
KVAGTADFIT ALQLDTKLDG IPSKVLSDAL EQARDARLTI LNTMADVING
610 620 630 640 650
PDEMSKFAPR ITTVKIPVAK IGELIGPKGK NINALTEETG ANISIEDDGT
660 670 680 690 700
VFISAADGAS AEAAIEKINA LANPQLPKVG ERFLGTVVKT TAFGAFVSLL
710 720 730 740 750
PGRDGLVHIS KLGNGKRVEK VDDVVKVGEK IQVEIADIDN RGKISLVPVV

EED
Length:753
Mass (Da):81,271
Last modified:October 1, 2002 - v1
Checksum:i6888719543BC3A1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA Translation: BAB99368.1
BX927153 Genomic DNA Translation: CAF20316.1
RefSeqiNP_601181.1, NC_003450.3
WP_011014796.1, NC_006958.1

Genome annotation databases

EnsemblBacteriaiBAB99368; BAB99368; BAB99368
CAF20316; CAF20316; cg2166
GeneIDi1019932
KEGGicgb:cg2166
cgl:NCgl1900
PATRICifig|196627.13.peg.1912

Similar proteinsi

Entry informationi

Entry nameiPNP_CORGL
AccessioniPrimary (citable) accession number: Q8NP50
Secondary accession number(s): Q6M462
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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