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Protein

Malto-oligosyltrehalose trehalohydrolase

Gene

Cgl2125

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of (1->4)-alpha-D-glucosidic linkage in 4-alpha-D-((1->4)-alpha-D-glucanosyl)(n) trehalose to yield trehalose and (1->4)-alpha-D-glucan.UniRule annotation

Pathwayi: trehalose biosynthesis

This protein is involved in the pathway trehalose biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway trehalose biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei270NucleophileUniRule annotation1
Active sitei307Proton donorUniRule annotation1
Sitei403Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase

Enzyme and pathway databases

BioCyciCORYNE:G18NG-11718-MONOMER.
UniPathwayiUPA00299.

Protein family/group databases

CAZyiCBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Malto-oligosyltrehalose trehalohydrolaseUniRule annotation (EC:3.2.1.141UniRule annotation)
Short name:
MTHaseUniRule annotation
Alternative name(s):
4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolaseUniRule annotation
Maltooligosyl trehalose trehalohydrolaseUniRule annotation
Gene namesi
Ordered Locus Names:Cgl2125Imported
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)Imported
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PRIDEiQ8NNR1.

2D gel databases

World-2DPAGEi0001:Q8NNR1.

Interactioni

Protein-protein interaction databases

STRINGi196627.NCgl2045.

Structurei

3D structure databases

ProteinModelPortaliQ8NNR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 476AamyInterPro annotationAdd BLAST352

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C9C. Bacteria.
COG0296. LUCA.
KOiK01236.
OMAiFTPMLFM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR022567. DUF3459.
IPR006047. Glyco_hydro_13_cat_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012768. Trehalose_TreZ.
PfamiView protein in Pfam
PF00128. Alpha-amylase. 2 hits.
PF11941. DUF3459. 1 hit.
PIRSFiPIRSF006337. Trehalose_TreZ. 1 hit.
SMARTiView protein in SMART
SM00642. Aamy. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR02402. trehalose_TreZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NNR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHSISHLSS PTGSIFTSLV AMLTSQSFSV WAPLPHDVHL ILNGETLPMH
60 70 80 90 100
KTEGSWWRAE IAPKAGDRYG FSLFDGSSWS KTLPDPRSTS QPDGVHGLSE
110 120 130 140 150
VSDDSYLWGD QQWTGRILPG SVLYELHVGT FSEDGTFEGV VDKLPYLRDL
160 170 180 190 200
GVTAIELLPV QPFGGNRNWG YDGVLWHAVH AGYGGPAGLK KLIDASHQAG
210 220 230 240 250
IAVYLDVVYN HFGPDGNYNG QFGPYTSGGS TGWGDVVNIN GHDSDEVRNY
260 270 280 290 300
ILDAARQWFE DFHVDGLRLD AVHSLDDRGA YSLLAQLTMV AEDVSAQTGI
310 320 330 340 350
PRSLIAESEL NDPKFVTSRE AGGFGLDAQW VDDIHHALHA LVSGERNGYY
360 370 380 390 400
SDFGSVDTLA KTLREVFEHT GNYSTYRGRN HGRPVHPDIT PASRFVTYTT
410 420 430 440 450
THDQTGNRAI GDRPSTTLTP EQQVLKAAII YSSPYTPMLF MGEEFGATTP
460 470 480 490 500
FAFFCSHTDP ELNRLTSEGR KREFARLGWN ADDIPSPELE STFTSSKLDW
510 520 530 540 550
EFTAEQRRIN DAYKQLLHLR HTLGFSQPNL LTLEVEHGEN WLSMANGRGR
560 570 580 590
ILANFSDDTI TVPLGGELIY SFTSPTVTDT STTLQPWGFA ILTRN
Length:595
Mass (Da):65,737
Last modified:October 1, 2002 - v1
Checksum:i501C18E977D616EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB99519.1.
RefSeqiNP_601327.2. NC_003450.3.
WP_011014899.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99519; BAB99519; BAB99519.
GeneIDi1020077.
KEGGicgl:NCgl2045.
PATRICifig|196627.13.peg.2064.

Similar proteinsi

Entry informationi

Entry nameiQ8NNR1_CORGL
AccessioniPrimary (citable) accession number: Q8NNR1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: August 30, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported