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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:Cgl2158, cg2369
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferasePRO_0000109168Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196627.cg2369.

Structurei

3D structure databases

ProteinModelPortaliQ8NNN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVQ. Bacteria.
COG0707. LUCA.
HOGENOMiHOG000218323.
KOiK02563.
OMAiHQTKNAM.

Family and domain databases

HAMAPiMF_00033. MurG. 1 hit.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NNN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVVVAGGGT AGHIEPALAV AEALRDKHGA TVSALGTARG LETTLVPDRG
60 70 80 90 100
FELHLIEPVP VPRKPNMDLL KLPFRVAKAL GQARKALKDT DAQAVIGFGG
110 120 130 140 150
YVSAPAYMAA KSLGLPFFVH EANARAGMAN KLGVKLGGVG LNAVAGSGMD
160 170 180 190 200
GDVVGIPIRA VLSGARDESA ADRARDTWGL DKDRQTIFVT GGSQGSVSIN
210 220 230 240 250
KAVEQAVDQL VEAGFQVLHA VGKKNELPAA KPGYHPVPFI DDMQAAYTVA
260 270 280 290 300
DLIVCRSGAM TVAEVTAAGV PAIYVPLPHG NGEQALNAQA VIKAGAARQI
310 320 330 340 350
DDADFTAQTL IDATLDILLH PSTHQSMSDA AKTSTAGNAS TVIADMIAAT

INSQHN
Length:356
Mass (Da):36,697
Last modified:March 7, 2006 - v2
Checksum:iB40AD8DB446F004C
GO

Sequence cautioni

The sequence BAB99551 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB66324 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAF20498 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041A → R in CAB66324 (Ref. 1) Curated
Sequence conflicti207 – 2071V → I in CAB66324 (Ref. 1) Curated
Sequence conflicti259 – 2591A → R in CAB66324 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242646 Genomic DNA. Translation: CAB66324.1. Different initiation.
BA000036 Genomic DNA. Translation: BAB99551.1. Different initiation.
BX927154 Genomic DNA. Translation: CAF20498.1. Different initiation.
RefSeqiNP_601360.1. NC_003450.3.

Genome annotation databases

EnsemblBacteriaiBAB99551; BAB99551; BAB99551.
CAF20498; CAF20498; cg2369.
GeneIDi1020110.
KEGGicgb:cg2369.
cgl:NCgl2078.
PATRICi21496320. VBICorGlu203724_2096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242646 Genomic DNA. Translation: CAB66324.1. Different initiation.
BA000036 Genomic DNA. Translation: BAB99551.1. Different initiation.
BX927154 Genomic DNA. Translation: CAF20498.1. Different initiation.
RefSeqiNP_601360.1. NC_003450.3.

3D structure databases

ProteinModelPortaliQ8NNN5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg2369.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB99551; BAB99551; BAB99551.
CAF20498; CAF20498; cg2369.
GeneIDi1020110.
KEGGicgb:cg2369.
cgl:NCgl2078.
PATRICi21496320. VBICorGlu203724_2096.

Phylogenomic databases

eggNOGiENOG4105DVQ. Bacteria.
COG0707. LUCA.
HOGENOMiHOG000218323.
KOiK02563.
OMAiHQTKNAM.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

HAMAPiMF_00033. MurG. 1 hit.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMURG_CORGL
AccessioniPrimary (citable) accession number: Q8NNN5
Secondary accession number(s): Q9L4H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.