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Protein

Cytochrome c oxidase polypeptide 4

Gene

ctaF

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of cytochrome c oxidase, its function is unknown.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Protein family/group databases

TCDBi3.D.4.4.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide 4 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 4
Cytochrome c oxidase polypeptide IV
Gene namesi
Name:ctaF
Ordered Locus Names:Cgl2194, cg2408
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001009 Componenti: Chromosome UP000000582 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Transmembranei40 – 6021HelicalSequence AnalysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143Cytochrome c oxidase polypeptide 4PRO_0000220015Add
BLAST

Interactioni

Subunit structurei

Associates with subunits I, II and III to form cytochrome c oxidase. The 4 subunit cytochrome c oxidase forms a supercomplex with cytochrome bc1.

Protein-protein interaction databases

STRINGi196627.cg2408.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG07397.
HOGENOMiHOG000237887.
OMAiLVFEYYR.
OrthoDBiEOG63FW2X.

Family and domain databases

InterProiIPR021050. Cyt_c_oxidase_su4_actinobac.
[Graphical view]
PfamiPF12270. Cyt_c_ox_IV. 1 hit.
[Graphical view]
PIRSFiPIRSF017385. CtaF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NNK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSSAKLMYG PTVFMAAMAV IYIFATMHVS DGGSVKGVEW VGSVALVLSA
60 70 80 90 100
GLTLMLGVYL HFTEVRVDVL PEDWEEAEVA DKAGTLGFFS PSSIWPAAMS
110 120 130 140
GAVGFLAFGV VYFHYWMIAV GLMLLIFTIT KLNLQYGVPK EKH
Length:143
Mass (Da):15,545
Last modified:October 1, 2002 - v1
Checksum:i7DF43A2C4C2AC2CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB99587.1.
BX927154 Genomic DNA. Translation: CAF20535.1.
RefSeqiNP_601398.1. NC_003450.3.
YP_226436.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99587; BAB99587; BAB99587.
GeneIDi1020146.
KEGGicgb:cg2408.
cgl:NCgl2114.
PATRICi21496388. VBICorGlu203724_2130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB99587.1.
BX927154 Genomic DNA. Translation: CAF20535.1.
RefSeqiNP_601398.1. NC_003450.3.
YP_226436.1. NC_006958.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg2408.

Protein family/group databases

TCDBi3.D.4.4.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB99587; BAB99587; BAB99587.
GeneIDi1020146.
KEGGicgb:cg2408.
cgl:NCgl2114.
PATRICi21496388. VBICorGlu203724_2130.

Phylogenomic databases

eggNOGiNOG07397.
HOGENOMiHOG000237887.
OMAiLVFEYYR.
OrthoDBiEOG63FW2X.

Family and domain databases

InterProiIPR021050. Cyt_c_oxidase_su4_actinobac.
[Graphical view]
PfamiPF12270. Cyt_c_ox_IV. 1 hit.
[Graphical view]
PIRSFiPIRSF017385. CtaF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. "Purification of a cytochrome bc1-aa3 supercomplex with quinol oxidase activity from Corynebacterium glutamicum. Identification of a fourth subunity of cytochrome aa3 oxidase and mutational analysis of diheme cytochrome c1."
    Niebisch A., Bott M.
    J. Biol. Chem. 278:4339-4346(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS A SUBUNIT OF CYTOCHROME C OXIDASE, DETECTION IN A SUPERCOMPLEX WITH MENAQUINOL-CYTOCHROME C REDUCTASE (CYTOCHROME BC1).
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiCOX4_CORGL
AccessioniPrimary (citable) accession number: Q8NNK3
Secondary accession number(s): Q6M3N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2002
Last modified: April 1, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.