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Q8NNK3

- COX4_CORGL

UniProt

Q8NNK3 - COX4_CORGL

Protein

Cytochrome c oxidase polypeptide 4

Gene

ctaF

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Part of cytochrome c oxidase, its function is unknown.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Protein family/group databases

    TCDBi3.D.4.4.2. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase polypeptide 4 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 4
    Cytochrome c oxidase polypeptide IV
    Gene namesi
    Name:ctaF
    Ordered Locus Names:Cgl2194, cg2408
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 143143Cytochrome c oxidase polypeptide 4PRO_0000220015Add
    BLAST

    Interactioni

    Subunit structurei

    Associates with subunits I, II and III to form cytochrome c oxidase. The 4 subunit cytochrome c oxidase forms a supercomplex with cytochrome bc1.

    Protein-protein interaction databases

    STRINGi196627.cg2408.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei107 – 12721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG07397.
    HOGENOMiHOG000237887.
    OMAiTISIVEP.
    OrthoDBiEOG63FW2X.

    Family and domain databases

    InterProiIPR021050. Cyt_c_oxidase_su4_actinobac.
    [Graphical view]
    PfamiPF12270. Cyt_c_ox_IV. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017385. CtaF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8NNK3-1 [UniParc]FASTAAdd to Basket

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    MKSSAKLMYG PTVFMAAMAV IYIFATMHVS DGGSVKGVEW VGSVALVLSA    50
    GLTLMLGVYL HFTEVRVDVL PEDWEEAEVA DKAGTLGFFS PSSIWPAAMS 100
    GAVGFLAFGV VYFHYWMIAV GLMLLIFTIT KLNLQYGVPK EKH 143
    Length:143
    Mass (Da):15,545
    Last modified:October 1, 2002 - v1
    Checksum:i7DF43A2C4C2AC2CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB99587.1.
    BX927154 Genomic DNA. Translation: CAF20535.1.
    RefSeqiNP_601398.1. NC_003450.3.
    YP_226436.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB99587; BAB99587; BAB99587.
    CAF20535; CAF20535; cg2408.
    GeneIDi1020146.
    KEGGicgb:cg2408.
    cgl:NCgl2114.
    PATRICi21496388. VBICorGlu203724_2130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB99587.1 .
    BX927154 Genomic DNA. Translation: CAF20535.1 .
    RefSeqi NP_601398.1. NC_003450.3.
    YP_226436.1. NC_006958.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg2408.

    Protein family/group databases

    TCDBi 3.D.4.4.2. the proton-translocating cytochrome oxidase (cox) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB99587 ; BAB99587 ; BAB99587 .
    CAF20535 ; CAF20535 ; cg2408 .
    GeneIDi 1020146.
    KEGGi cgb:cg2408.
    cgl:NCgl2114.
    PATRICi 21496388. VBICorGlu203724_2130.

    Phylogenomic databases

    eggNOGi NOG07397.
    HOGENOMi HOG000237887.
    OMAi TISIVEP.
    OrthoDBi EOG63FW2X.

    Family and domain databases

    InterProi IPR021050. Cyt_c_oxidase_su4_actinobac.
    [Graphical view ]
    Pfami PF12270. Cyt_c_ox_IV. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017385. CtaF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    3. "Purification of a cytochrome bc1-aa3 supercomplex with quinol oxidase activity from Corynebacterium glutamicum. Identification of a fourth subunity of cytochrome aa3 oxidase and mutational analysis of diheme cytochrome c1."
      Niebisch A., Bott M.
      J. Biol. Chem. 278:4339-4346(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION AS A SUBUNIT OF CYTOCHROME C OXIDASE, DETECTION IN A SUPERCOMPLEX WITH MENAQUINOL-CYTOCHROME C REDUCTASE (CYTOCHROME BC1).
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiCOX4_CORGL
    AccessioniPrimary (citable) accession number: Q8NNK3
    Secondary accession number(s): Q6M3N9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3