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Q8NNK3

- COX4_CORGL

UniProt

Q8NNK3 - COX4_CORGL

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Protein
Cytochrome c oxidase polypeptide 4
Gene
ctaF, Cgl2194, cg2408
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Part of cytochrome c oxidase, its function is unknown.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Protein family/group databases

TCDBi3.D.4.4.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide 4 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 4
Cytochrome c oxidase polypeptide IV
Gene namesi
Name:ctaF
Ordered Locus Names:Cgl2194, cg2408
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed prediction
Add
BLAST
Transmembranei40 – 6021Helical; Reviewed prediction
Add
BLAST
Transmembranei86 – 10621Helical; Reviewed prediction
Add
BLAST
Transmembranei107 – 12721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143Cytochrome c oxidase polypeptide 4
PRO_0000220015Add
BLAST

Interactioni

Subunit structurei

Associates with subunits I, II and III to form cytochrome c oxidase. The 4 subunit cytochrome c oxidase forms a supercomplex with cytochrome bc1.1 Publication

Protein-protein interaction databases

STRINGi196627.cg2408.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG07397.
HOGENOMiHOG000237887.
OMAiTISIVEP.
OrthoDBiEOG63FW2X.

Family and domain databases

InterProiIPR021050. Cyt_c_oxidase_su4_actinobac.
[Graphical view]
PfamiPF12270. Cyt_c_ox_IV. 1 hit.
[Graphical view]
PIRSFiPIRSF017385. CtaF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NNK3-1 [UniParc]FASTAAdd to Basket

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MKSSAKLMYG PTVFMAAMAV IYIFATMHVS DGGSVKGVEW VGSVALVLSA    50
GLTLMLGVYL HFTEVRVDVL PEDWEEAEVA DKAGTLGFFS PSSIWPAAMS 100
GAVGFLAFGV VYFHYWMIAV GLMLLIFTIT KLNLQYGVPK EKH 143
Length:143
Mass (Da):15,545
Last modified:October 1, 2002 - v1
Checksum:i7DF43A2C4C2AC2CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000036 Genomic DNA. Translation: BAB99587.1.
BX927154 Genomic DNA. Translation: CAF20535.1.
RefSeqiNP_601398.1. NC_003450.3.
YP_226436.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99587; BAB99587; BAB99587.
CAF20535; CAF20535; cg2408.
GeneIDi1020146.
KEGGicgb:cg2408.
cgl:NCgl2114.
PATRICi21496388. VBICorGlu203724_2130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000036 Genomic DNA. Translation: BAB99587.1 .
BX927154 Genomic DNA. Translation: CAF20535.1 .
RefSeqi NP_601398.1. NC_003450.3.
YP_226436.1. NC_006958.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg2408.

Protein family/group databases

TCDBi 3.D.4.4.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB99587 ; BAB99587 ; BAB99587 .
CAF20535 ; CAF20535 ; cg2408 .
GeneIDi 1020146.
KEGGi cgb:cg2408.
cgl:NCgl2114.
PATRICi 21496388. VBICorGlu203724_2130.

Phylogenomic databases

eggNOGi NOG07397.
HOGENOMi HOG000237887.
OMAi TISIVEP.
OrthoDBi EOG63FW2X.

Family and domain databases

InterProi IPR021050. Cyt_c_oxidase_su4_actinobac.
[Graphical view ]
Pfami PF12270. Cyt_c_ox_IV. 1 hit.
[Graphical view ]
PIRSFi PIRSF017385. CtaF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. "Purification of a cytochrome bc1-aa3 supercomplex with quinol oxidase activity from Corynebacterium glutamicum. Identification of a fourth subunity of cytochrome aa3 oxidase and mutational analysis of diheme cytochrome c1."
    Niebisch A., Bott M.
    J. Biol. Chem. 278:4339-4346(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS A SUBUNIT OF CYTOCHROME C OXIDASE, DETECTION IN A SUPERCOMPLEX WITH MENAQUINOL-CYTOCHROME C REDUCTASE (CYTOCHROME BC1).
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiCOX4_CORGL
AccessioniPrimary (citable) accession number: Q8NNK3
Secondary accession number(s): Q6M3N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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