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Q8NNK2

- COX2_CORGL

UniProt

Q8NNK2 - COX2_CORGL

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Protein
Cytochrome c oxidase subunit 2
Gene
ctaC, Cgl2195, cg2409
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 2 copper A ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei29 – 291Not N-palmitoylated
Metal bindingi244 – 2441Copper A1 By similarity
Metal bindingi285 – 2851Copper A1 By similarity
Metal bindingi285 – 2851Copper A2 By similarity
Metal bindingi287 – 2871Copper A2; via carbonyl oxygen By similarity
Metal bindingi289 – 2891Copper A1 By similarity
Metal bindingi289 – 2891Copper A2 By similarity
Metal bindingi293 – 2931Copper A2 By similarity
Metal bindingi296 – 2961Copper A1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciCGLU196627:GJDM-2169-MONOMER.

Protein family/group databases

TCDBi3.D.4.4.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Ordered Locus Names:Cgl2195, cg2409
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8421Helical; Reviewed prediction
Add
BLAST
Transmembranei107 – 12721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 Publication
Add
BLAST
Chaini29 – 359331Cytochrome c oxidase subunit 2
PRO_0000006054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi29 – 291S-diacylglycerol cysteine

Keywords - PTMi

Lipoprotein

Interactioni

Subunit structurei

Associates with subunits I, III and IV to form cytochrome c oxidase. The 4 subunit cytochrome c oxidase forms a supercomplex with the menaquinol-cytochrome c reductase complex (cytochrome bc1).1 Publication

Protein-protein interaction databases

STRINGi196627.cg2409.

Structurei

3D structure databases

ProteinModelPortaliQ8NNK2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000245527.
KOiK02275.
OMAiMRELWTW.
OrthoDBiEOG68SVXT.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NNK2-1 [UniParc]FASTAAdd to Basket

« Hide

MEQQNKRGLK RKALLGGVLG LGGLAMAGCE VAPPGGVLGD FLRMGWPDGI    50
TPEAVAMGNF WSWVWVAAWI IGIIMWGLFL TAIFAWGAKR AEKRGEGEFP 100
KQLQYNVPLE LVLTIVPIII VMVLFFFTVQ TQDKVTALDK NPEVTVDVTA 150
YQWNWKFGYS EIDGSLAPGG QDYQGSDPER QAAAEASKKD PSGDNPIHGN 200
SKSDVSYLEF NRIETLGTTD EIPVMVLPVN TPIEFNLASA DVAHSFWVPE 250
FLFKRDAYAH PEANKSQRVF QIEEITEEGA FVGRCAEMCG TYHAMMNFEL 300
RVVDRDSFAE YISFRDSNPD ATNAQALEHI GQAPYATSTS PFVSDRTATR 350
DGENTQSNA 359
Length:359
Mass (Da):39,632
Last modified:October 1, 2002 - v1
Checksum:i5BB65F6AB2BE493A
GO

Mass spectrometryi

Molecular mass is 37314.7±83.2 Da from positions 29 - 359. Determined by MALDI. 1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691W → C in BAB64407. 1 Publication
Sequence conflicti310 – 3101E → V in BAB64407. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB052749 Genomic DNA. Translation: BAB64407.1.
BA000036 Genomic DNA. Translation: BAB99588.1.
BX927154 Genomic DNA. Translation: CAF20536.1.
RefSeqiNP_601399.1. NC_003450.3.
YP_226437.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99588; BAB99588; BAB99588.
CAF20536; CAF20536; cg2409.
GeneIDi1020147.
KEGGicgb:cg2409.
cgl:NCgl2115.
PATRICi21496390. VBICorGlu203724_2131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB052749 Genomic DNA. Translation: BAB64407.1 .
BA000036 Genomic DNA. Translation: BAB99588.1 .
BX927154 Genomic DNA. Translation: CAF20536.1 .
RefSeqi NP_601399.1. NC_003450.3.
YP_226437.1. NC_006958.1.

3D structure databases

ProteinModelPortali Q8NNK2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg2409.

Protein family/group databases

TCDBi 3.D.4.4.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB99588 ; BAB99588 ; BAB99588 .
CAF20536 ; CAF20536 ; cg2409 .
GeneIDi 1020147.
KEGGi cgb:cg2409.
cgl:NCgl2115.
PATRICi 21496390. VBICorGlu203724_2131.

Phylogenomic databases

eggNOGi COG1622.
HOGENOMi HOG000245527.
KOi K02275.
OMAi MRELWTW.
OrthoDBi EOG68SVXT.

Enzyme and pathway databases

BioCyci CGLU196627:GJDM-2169-MONOMER.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cytochrome c oxidase contains an extra charged amino acid cluster in a new type of respiratory chain in the amino acid-producing Gram-positive bacterium Corynebacterium glutamicum."
    Sakamoto J., Shibata T., Mine T., Miyahara R., Torigoe T., Noguchi S., Matsushita K., Sone N.
    Microbiology 147:2865-2871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 29-50, SUBUNIT, HEME CHARACTERIZATION, DIACYLGLYCEROL AT CYS-29, MASS SPECTROMETRY.
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  4. "Purification of a cytochrome bc1-aa3 supercomplex with quinol oxidase activity from Corynebacterium glutamicum. Identification of a fourth subunity of cytochrome aa3 oxidase and mutational analysis of diheme cytochrome c1."
    Niebisch A., Bott M.
    J. Biol. Chem. 278:4339-4346(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DETECTION IN A SUPERCOMPLEX WITH MENAQUINOL-CYTOCHROME C REDUCTASE (CYTOCHROME BC1).
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiCOX2_CORGL
AccessioniPrimary (citable) accession number: Q8NNK2
Secondary accession number(s): Q6M3N8, Q93HZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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