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Q8NND3

- GLMS_CORGL

UniProt

Q8NND3 - GLMS_CORGL

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei618 – 6181For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:Cgl2271, cg2492
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 623622Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135327Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi196627.cg2492.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NND3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 228227Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini295 – 435141SIS 1UniRule annotationAdd
    BLAST
    Domaini468 – 613146SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiCRIPCEV.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8NND3-1 [UniParc]FASTAAdd to Basket

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    MCGIVGYIGQ AGDSRDYFAL DVVVEGLRRL EYRGYDSAGI AIHANGEISY    50
    RKKAGKVAAL DAEIAKAPLP DSILGIGHTR WATHGGPTDV NAHPHVVSNG 100
    KLAVVHNGII ENFAELRSEL SAKGYNFVSD TDTEVAASLL AEIYNTQANG 150
    DLTLAMQLTG QRLEGAFTLL AIHADHDDRI VAARRNSPLV IGVGEGENFL 200
    GSDVSGFIDY TRKAVELAND QVVTITADDY AITNFDGSEA VGKPFDVEWD 250
    AAAAEKGGFG SFMEKEIHDQ PAAVRDTLMG RLDEDGKLVL DELRIDEAIL 300
    RSVDKIVIVA CGTAAYAGQV ARYAIEHWCR IPTEVELAHE FRYRDPILNE 350
    KTLVVALSQS GETMDTLMAV RHAREQGAKV VAICNTVGST LPREADASLY 400
    TYAGPEIAVA STKAFLAQIT ASYLLGLYLA QLRGNKFADE VSSILDSLRE 450
    MPEKIQQVID AEEQIKKLGQ DMADAKSVLF LGRHVGFPVA LEGALKLKEI 500
    AYLHAEGFAA GELKHGPIAL VEEGQPIFVI VPSPRGRDSL HSKVVSNIQE 550
    IRARGAVTIV IAEEGDEAVN DYANFIIRIP QAPTLMQPLL STVPLQIFAC 600
    AVATAKGYNV DQPRNLAKSV TVE 623
    Length:623
    Mass (Da):67,215
    Last modified:January 23, 2007 - v2
    Checksum:i4A24510056F4B9E3
    GO

    Sequence cautioni

    The sequence CAF20613.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB99664.1.
    BX927154 Genomic DNA. Translation: CAF20613.1. Different initiation.
    RefSeqiNP_601471.2. NC_003450.3.
    YP_226514.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB99664; BAB99664; BAB99664.
    CAF20613; CAF20613; cg2492.
    GeneIDi1020224.
    KEGGicgb:cg2492.
    cgl:NCgl2191.
    PATRICi21496544. VBICorGlu203724_2204.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB99664.1 .
    BX927154 Genomic DNA. Translation: CAF20613.1 . Different initiation.
    RefSeqi NP_601471.2. NC_003450.3.
    YP_226514.1. NC_006958.1.

    3D structure databases

    ProteinModelPortali Q8NND3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg2492.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB99664 ; BAB99664 ; BAB99664 .
    CAF20613 ; CAF20613 ; cg2492 .
    GeneIDi 1020224.
    KEGGi cgb:cg2492.
    cgl:NCgl2191.
    PATRICi 21496544. VBICorGlu203724_2204.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi CRIPCEV.
    OrthoDBi EOG6KT2Q1.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiGLMS_CORGL
    AccessioniPrimary (citable) accession number: Q8NND3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3