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Q8NND3

- GLMS_CORGL

UniProt

Q8NND3 - GLMS_CORGL

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
glmS, Cgl2271, cg2492
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei618 – 6181For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:Cgl2271, cg2492
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 623622Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationPRO_0000135327Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi196627.cg2492.

Structurei

3D structure databases

ProteinModelPortaliQ8NND3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 228227Glutamine amidotransferase type-2Add
BLAST
Domaini295 – 435141SIS 1Add
BLAST
Domaini468 – 613146SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiCRIPCEV.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NND3-1 [UniParc]FASTAAdd to Basket

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MCGIVGYIGQ AGDSRDYFAL DVVVEGLRRL EYRGYDSAGI AIHANGEISY    50
RKKAGKVAAL DAEIAKAPLP DSILGIGHTR WATHGGPTDV NAHPHVVSNG 100
KLAVVHNGII ENFAELRSEL SAKGYNFVSD TDTEVAASLL AEIYNTQANG 150
DLTLAMQLTG QRLEGAFTLL AIHADHDDRI VAARRNSPLV IGVGEGENFL 200
GSDVSGFIDY TRKAVELAND QVVTITADDY AITNFDGSEA VGKPFDVEWD 250
AAAAEKGGFG SFMEKEIHDQ PAAVRDTLMG RLDEDGKLVL DELRIDEAIL 300
RSVDKIVIVA CGTAAYAGQV ARYAIEHWCR IPTEVELAHE FRYRDPILNE 350
KTLVVALSQS GETMDTLMAV RHAREQGAKV VAICNTVGST LPREADASLY 400
TYAGPEIAVA STKAFLAQIT ASYLLGLYLA QLRGNKFADE VSSILDSLRE 450
MPEKIQQVID AEEQIKKLGQ DMADAKSVLF LGRHVGFPVA LEGALKLKEI 500
AYLHAEGFAA GELKHGPIAL VEEGQPIFVI VPSPRGRDSL HSKVVSNIQE 550
IRARGAVTIV IAEEGDEAVN DYANFIIRIP QAPTLMQPLL STVPLQIFAC 600
AVATAKGYNV DQPRNLAKSV TVE 623
Length:623
Mass (Da):67,215
Last modified:January 23, 2007 - v2
Checksum:i4A24510056F4B9E3
GO

Sequence cautioni

The sequence CAF20613.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000036 Genomic DNA. Translation: BAB99664.1.
BX927154 Genomic DNA. Translation: CAF20613.1. Different initiation.
RefSeqiNP_601471.2. NC_003450.3.
YP_226514.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99664; BAB99664; BAB99664.
CAF20613; CAF20613; cg2492.
GeneIDi1020224.
KEGGicgb:cg2492.
cgl:NCgl2191.
PATRICi21496544. VBICorGlu203724_2204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000036 Genomic DNA. Translation: BAB99664.1 .
BX927154 Genomic DNA. Translation: CAF20613.1 . Different initiation.
RefSeqi NP_601471.2. NC_003450.3.
YP_226514.1. NC_006958.1.

3D structure databases

ProteinModelPortali Q8NND3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg2492.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB99664 ; BAB99664 ; BAB99664 .
CAF20613 ; CAF20613 ; cg2492 .
GeneIDi 1020224.
KEGGi cgb:cg2492.
cgl:NCgl2191.
PATRICi 21496544. VBICorGlu203724_2204.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi CRIPCEV.
OrthoDBi EOG6KT2Q1.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiGLMS_CORGL
AccessioniPrimary (citable) accession number: Q8NND3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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