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Q8NMT3

- GLSA_CORGL

UniProt

Q8NMT3 - GLSA_CORGL

Protein

Glutaminase

Gene

glsA

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (24 May 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei65 – 651SubstrateBy similarity
    Binding sitei114 – 1141SubstrateBy similarity
    Binding sitei160 – 1601SubstrateBy similarity
    Binding sitei167 – 1671SubstrateBy similarity
    Binding sitei191 – 1911SubstrateBy similarity
    Binding sitei243 – 2431SubstrateBy similarity
    Binding sitei261 – 2611Substrate; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutaminase (EC:3.5.1.2)
    Gene namesi
    Name:glsA
    Ordered Locus Names:Cgl2482, cg2728
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413GlutaminasePRO_0000110606Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi196627.cg2728.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NMT3.
    SMRiQ8NMT3. Positions 3-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini316 – 41398STASAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 307285GlutaminaseAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glutaminase family.Curated
    Contains 1 STAS domain.Curated

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OMAiQCSVGVT.
    OrthoDBiEOG6N94BK.

    Family and domain databases

    Gene3Di3.30.750.24. 1 hit.
    3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    IPR002645. STAS_dom.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
    PROSITEiPS50801. STAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NMT3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTMPIPEYL HEILDDVRDT TSGELADYIP ELKSADPNPL AVALCTVNGH    50
    IYSAGDDDIE FTMQSISKPF AYALALQECG FDEVSASVAL EPSGEAFNEL 100
    SLDGENRPMN PMINAGAIAI NQLINGSDST VEDRVEKIRH YFSELAGREL 150
    TIDRVLAESE LAGADRNLSI AHMLRNYGVI EDEAHDAVLS YTLQCAIKVT 200
    TRDLAVMTAT LAAGGTHPIT GKKLLDARVC RLTLSVMASA GMYDEAGQWL 250
    STVGIPAKSG VAGGLIGILP GQLGIATFSP RLNPKGNSVR GVKIFKQLSD 300
    DMGLHLMSTE QVSGHAVRSI TRDGDTTFIQ MQGAMNFSAS ESFLHAIVEH 350
    NFEGTEVVLD LTRVLSFHPV AIRMIKEGLK RIRDAGFEVF ILDPDDVLPD 400
    FMFSDGTICK ERV 413
    Length:413
    Mass (Da):44,748
    Last modified:May 24, 2004 - v2
    Checksum:i91ADD397B9FFE473
    GO

    Sequence cautioni

    The sequence BAB99875.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB99875.1. Different initiation.
    BX927155 Genomic DNA. Translation: CAF21143.1.
    RefSeqiNP_601682.1. NC_003450.3.
    YP_226722.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB99875; BAB99875; BAB99875.
    CAF21143; CAF21143; cg2728.
    GeneIDi1020428.
    KEGGicgb:cg2728.
    cgl:NCgl2395.
    PATRICi21496976. VBICorGlu203724_2414.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000036 Genomic DNA. Translation: BAB99875.1 . Different initiation.
    BX927155 Genomic DNA. Translation: CAF21143.1 .
    RefSeqi NP_601682.1. NC_003450.3.
    YP_226722.1. NC_006958.1.

    3D structure databases

    ProteinModelPortali Q8NMT3.
    SMRi Q8NMT3. Positions 3-349.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg2728.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB99875 ; BAB99875 ; BAB99875 .
    CAF21143 ; CAF21143 ; cg2728 .
    GeneIDi 1020428.
    KEGGi cgb:cg2728.
    cgl:NCgl2395.
    PATRICi 21496976. VBICorGlu203724_2414.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OMAi QCSVGVT.
    OrthoDBi EOG6N94BK.

    Family and domain databases

    Gene3Di 3.30.750.24. 1 hit.
    3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    IPR002645. STAS_dom.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    PROSITEi PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiGLSA_CORGL
    AccessioniPrimary (citable) accession number: Q8NMT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3