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Q8NMT3

- GLSA_CORGL

UniProt

Q8NMT3 - GLSA_CORGL

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Protein
Glutaminase
Gene
glsA, Cgl2482, cg2728
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651Substrate By similarity
Binding sitei114 – 1141Substrate By similarity
Binding sitei160 – 1601Substrate By similarity
Binding sitei167 – 1671Substrate By similarity
Binding sitei191 – 1911Substrate By similarity
Binding sitei243 – 2431Substrate By similarity
Binding sitei261 – 2611Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:Cgl2482, cg2728
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413GlutaminaseUniRule annotation
PRO_0000110606Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi196627.cg2728.

Structurei

3D structure databases

ProteinModelPortaliQ8NMT3.
SMRiQ8NMT3. Positions 3-349.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini316 – 41398STAS
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 307285GlutaminaseUniRule annotation
Add
BLAST

Sequence similaritiesi

Belongs to the glutaminase family.
Contains 1 STAS domain.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiQCSVGVT.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NMT3-1 [UniParc]FASTAAdd to Basket

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MLTMPIPEYL HEILDDVRDT TSGELADYIP ELKSADPNPL AVALCTVNGH    50
IYSAGDDDIE FTMQSISKPF AYALALQECG FDEVSASVAL EPSGEAFNEL 100
SLDGENRPMN PMINAGAIAI NQLINGSDST VEDRVEKIRH YFSELAGREL 150
TIDRVLAESE LAGADRNLSI AHMLRNYGVI EDEAHDAVLS YTLQCAIKVT 200
TRDLAVMTAT LAAGGTHPIT GKKLLDARVC RLTLSVMASA GMYDEAGQWL 250
STVGIPAKSG VAGGLIGILP GQLGIATFSP RLNPKGNSVR GVKIFKQLSD 300
DMGLHLMSTE QVSGHAVRSI TRDGDTTFIQ MQGAMNFSAS ESFLHAIVEH 350
NFEGTEVVLD LTRVLSFHPV AIRMIKEGLK RIRDAGFEVF ILDPDDVLPD 400
FMFSDGTICK ERV 413
Length:413
Mass (Da):44,748
Last modified:May 24, 2004 - v2
Checksum:i91ADD397B9FFE473
GO

Sequence cautioni

The sequence BAB99875.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000036 Genomic DNA. Translation: BAB99875.1. Different initiation.
BX927155 Genomic DNA. Translation: CAF21143.1.
RefSeqiNP_601682.1. NC_003450.3.
YP_226722.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99875; BAB99875; BAB99875.
CAF21143; CAF21143; cg2728.
GeneIDi1020428.
KEGGicgb:cg2728.
cgl:NCgl2395.
PATRICi21496976. VBICorGlu203724_2414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000036 Genomic DNA. Translation: BAB99875.1 . Different initiation.
BX927155 Genomic DNA. Translation: CAF21143.1 .
RefSeqi NP_601682.1. NC_003450.3.
YP_226722.1. NC_006958.1.

3D structure databases

ProteinModelPortali Q8NMT3.
SMRi Q8NMT3. Positions 3-349.
ModBasei Search...

Protein-protein interaction databases

STRINGi 196627.cg2728.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB99875 ; BAB99875 ; BAB99875 .
CAF21143 ; CAF21143 ; cg2728 .
GeneIDi 1020428.
KEGGi cgb:cg2728.
cgl:NCgl2395.
PATRICi 21496976. VBICorGlu203724_2414.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi QCSVGVT.
OrthoDBi EOG6N94BK.

Family and domain databases

Gene3Di 3.30.750.24. 1 hit.
3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
IPR002645. STAS_dom.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
PROSITEi PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiGLSA_CORGL
AccessioniPrimary (citable) accession number: Q8NMT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: July 9, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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