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Protein

Glutaminase

Gene

glsA

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei65SubstrateBy similarity1
Binding sitei114SubstrateBy similarity1
Binding sitei160SubstrateBy similarity1
Binding sitei167SubstrateBy similarity1
Binding sitei191SubstrateBy similarity1
Binding sitei243SubstrateBy similarity1
Binding sitei261Substrate; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCORYNE:G18NG-12085-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:Cgl2482, cg2728
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001106061 – 413GlutaminaseAdd BLAST413

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi196627.cg2728.

Structurei

3D structure databases

ProteinModelPortaliQ8NMT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini316 – 413STASAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 307GlutaminaseAdd BLAST285

Sequence similaritiesi

Belongs to the glutaminase family.Curated
Contains 1 STAS domain.Curated

Phylogenomic databases

eggNOGiENOG4105CSV. Bacteria.
COG2066. LUCA.
HOGENOMiHOG000216890.
KOiK01425.
OMAiVNSIMAT.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NMT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTMPIPEYL HEILDDVRDT TSGELADYIP ELKSADPNPL AVALCTVNGH
60 70 80 90 100
IYSAGDDDIE FTMQSISKPF AYALALQECG FDEVSASVAL EPSGEAFNEL
110 120 130 140 150
SLDGENRPMN PMINAGAIAI NQLINGSDST VEDRVEKIRH YFSELAGREL
160 170 180 190 200
TIDRVLAESE LAGADRNLSI AHMLRNYGVI EDEAHDAVLS YTLQCAIKVT
210 220 230 240 250
TRDLAVMTAT LAAGGTHPIT GKKLLDARVC RLTLSVMASA GMYDEAGQWL
260 270 280 290 300
STVGIPAKSG VAGGLIGILP GQLGIATFSP RLNPKGNSVR GVKIFKQLSD
310 320 330 340 350
DMGLHLMSTE QVSGHAVRSI TRDGDTTFIQ MQGAMNFSAS ESFLHAIVEH
360 370 380 390 400
NFEGTEVVLD LTRVLSFHPV AIRMIKEGLK RIRDAGFEVF ILDPDDVLPD
410
FMFSDGTICK ERV
Length:413
Mass (Da):44,748
Last modified:May 24, 2004 - v2
Checksum:i91ADD397B9FFE473
GO

Sequence cautioni

The sequence BAB99875 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB99875.1. Different initiation.
BX927155 Genomic DNA. Translation: CAF21143.1.
RefSeqiNP_601682.1. NC_003450.3.
WP_003860838.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99875; BAB99875; BAB99875.
CAF21143; CAF21143; cg2728.
GeneIDi1020428.
KEGGicgb:cg2728.
cgl:NCgl2395.
PATRICi21496976. VBICorGlu203724_2414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB99875.1. Different initiation.
BX927155 Genomic DNA. Translation: CAF21143.1.
RefSeqiNP_601682.1. NC_003450.3.
WP_003860838.1. NC_006958.1.

3D structure databases

ProteinModelPortaliQ8NMT3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg2728.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB99875; BAB99875; BAB99875.
CAF21143; CAF21143; cg2728.
GeneIDi1020428.
KEGGicgb:cg2728.
cgl:NCgl2395.
PATRICi21496976. VBICorGlu203724_2414.

Phylogenomic databases

eggNOGiENOG4105CSV. Bacteria.
COG2066. LUCA.
HOGENOMiHOG000216890.
KOiK01425.
OMAiVNSIMAT.

Enzyme and pathway databases

BioCyciCORYNE:G18NG-12085-MONOMER.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLSA_CORGL
AccessioniPrimary (citable) accession number: Q8NMT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 2, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.