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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401Desacetylmycothiol; via amide nitrogenUniRule annotation
Binding sitei179 – 1791DesacetylmycothiolUniRule annotation
Binding sitei218 – 2181DesacetylmycothiolUniRule annotation
Binding sitei226 – 2261DesacetylmycothiolUniRule annotation
Binding sitei264 – 2641Desacetylmycothiol; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:Cgl2576, cg2847
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Mycothiol acetyltransferasePRO_0000400250Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi196627.cg2847.

Structurei

3D structure databases

ProteinModelPortaliQ8NMJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 168156N-acetyltransferase 1UniRule annotationAdd
BLAST
Domaini159 – 292134N-acetyltransferase 2UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni77 – 793Acetyl-CoA binding 1UniRule annotation
Regioni230 – 2323Acetyl-CoA binding 2UniRule annotation
Regioni237 – 2437Acetyl-CoA binding 2UniRule annotation

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation
Contains 2 N-acetyltransferase domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.
OrthoDBiEOG69D3BP.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF13508. Acetyltransf_7. 1 hit.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NMJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSDRIKST QIALDRDLRE QALLLLKEVR AVDGVDALSE QFVRGLAEPG
60 70 80 90 100
LGHSHLIVTL NDKLVGLAAT DEETTELAVH PAHRRQGIGK ALIDATPTSS
110 120 130 140 150
IWAHGNTAGA QALASTLRMK KTRELLVMEI SDRALDDSAA YKDPDGITHS
160 170 180 190 200
SLANAPVEKS VAEAKWLQSN NEAFDWHPEQ GGWTTHRLAQ AQKADWYKDS
210 220 230 240 250
DVLFLWDGEE IVGFHWVKQH SPELQEIYVV GLSSAYRGRG LGDPLVRLGL
260 270 280 290
HHMRAHGARK VILYVEAGNT PAVAAYEKLG FTVAESHVVY EK
Length:292
Mass (Da):32,134
Last modified:October 1, 2002 - v1
Checksum:i818B2E41359A117B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB99969.1.
BX927155 Genomic DNA. Translation: CAF21237.1.
RefSeqiNP_601774.1. NC_003450.3.
WP_011015225.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB99969; BAB99969; BAB99969.
CAF21237; CAF21237; cg2847.
GeneIDi1020522.
KEGGicgb:cg2847.
cgl:NCgl2487.
PATRICi21497194. VBICorGlu203724_2510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAB99969.1.
BX927155 Genomic DNA. Translation: CAF21237.1.
RefSeqiNP_601774.1. NC_003450.3.
WP_011015225.1. NC_006958.1.

3D structure databases

ProteinModelPortaliQ8NMJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg2847.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB99969; BAB99969; BAB99969.
CAF21237; CAF21237; cg2847.
GeneIDi1020522.
KEGGicgb:cg2847.
cgl:NCgl2487.
PATRICi21497194. VBICorGlu203724_2510.

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.
OrthoDBiEOG69D3BP.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF13508. Acetyltransf_7. 1 hit.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiMSHD_CORGL
AccessioniPrimary (citable) accession number: Q8NMJ7
Secondary accession number(s): Q6M2Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.