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Protein

Glycerol kinase

Gene

glpK

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (glpK)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei17 – 171SubstrateUniRule annotation
Binding sitei21 – 211ATPUniRule annotation
Binding sitei139 – 1391SubstrateUniRule annotation
Binding sitei278 – 2781ATPUniRule annotation
Binding sitei322 – 3221ATP; via carbonyl oxygenUniRule annotation
Binding sitei326 – 3261ATP; via amide nitrogenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 193ATPUniRule annotation
Nucleotide bindingi423 – 4275ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:Cgl2890, cg3198
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Glycerol kinasePRO_0000059448Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196627.cg3198.

Structurei

3D structure databases

ProteinModelPortaliQ8NLP9.
SMRiQ8NLP9. Positions 8-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni87 – 882Substrate bindingUniRule annotation
Regioni256 – 2572Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JQ0. Bacteria.
COG0554. LUCA.
HOGENOMiHOG000222134.
KOiK00864.
OMAiHTNQWDD.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin. 1 hit.
InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NLP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRISKANAYV AAIDQGTTST RCIFIDAQGK VVSSASKEHR QIFPQQGWVE
60 70 80 90 100
HDPEEIWDNI RSVVSQAMVS IDITPHEVAS LGVTNQRETT VVWDKHTGEP
110 120 130 140 150
VYNAIVWQDT RTSDICLEIA GEEGQEKWLD RTGLLINSYP SGPKIKWILD
160 170 180 190 200
NVEGARERAE KGDLLFGTMD TWVLWNLTGG VRGDDGDDAI HVTDVTNASR
210 220 230 240 250
TLLMDLRTQQ WDPELCEALD IPMSMLPEIR PSVGEFRSVR HRGTLADVPI
260 270 280 290 300
TGVLGDQQAA LFGQGGFHEG AAKNTYGTGL FLLMNTGTSL KISEHGLLST
310 320 330 340 350
IAYQREGSAP VYALEGSVSM GGSLVQWLRD NLQLIPNAPA IENLAREVED
360 370 380 390 400
NGGVHVVPAF TGLFAPRWRP DARGVITGLT RFANRKHIAR AVLEANAFQT
410 420 430 440 450
REVVDAMAKD AGKALESLRV DGAMVENDLL MQMQADFLGI DVQRLEDVET
460 470 480 490 500
TAVGVAFAAG LGSGFFKTTD EIEKLIAVKK VWNPDMSEEE RERRYAEWNR

AVEHSYDQA
Length:509
Mass (Da):56,145
Last modified:October 1, 2002 - v1
Checksum:iEC8B65618D84C480
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAC00284.1.
BX927156 Genomic DNA. Translation: CAF20913.1.
RefSeqiNP_602080.1. NC_003450.3.
WP_003857839.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAC00284; BAC00284; BAC00284.
CAF20913; CAF20913; cg3198.
GeneIDi1020833.
KEGGicgb:cg3198.
cgl:NCgl2790.
PATRICi21497820. VBICorGlu203724_2821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000036 Genomic DNA. Translation: BAC00284.1.
BX927156 Genomic DNA. Translation: CAF20913.1.
RefSeqiNP_602080.1. NC_003450.3.
WP_003857839.1. NC_006958.1.

3D structure databases

ProteinModelPortaliQ8NLP9.
SMRiQ8NLP9. Positions 8-506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg3198.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC00284; BAC00284; BAC00284.
CAF20913; CAF20913; cg3198.
GeneIDi1020833.
KEGGicgb:cg3198.
cgl:NCgl2790.
PATRICi21497820. VBICorGlu203724_2821.

Phylogenomic databases

eggNOGiENOG4108JQ0. Bacteria.
COG0554. LUCA.
HOGENOMiHOG000222134.
KOiK00864.
OMAiHTNQWDD.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin. 1 hit.
InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLPK_CORGL
AccessioniPrimary (citable) accession number: Q8NLP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.