ID   MSRA_CORGL              Reviewed;         217 AA.
AC   Q8NLL5; Q6M1T9;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 37.
DE   RecName: Full=Peptide methionine sulfoxide reductase msrA;
DE            Short=Protein-methionine-S-oxide reductase;
DE            EC=1.8.4.11;
DE   AltName: Full=Peptide-methionine (S)-S-oxide reductase;
DE            Short=Peptide Met(O) reductase;
GN   Name=msrA; OrderedLocusNames=Cgl2926, cg3236;
OS   Corynebacterium glutamicum (Brevibacterium flavum).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Corynebacteriaceae; Corynebacterium.
OX   NCBI_TaxID=1718;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
RA   Nakagawa S.;
RT   "Complete genomic sequence of Corynebacterium glutamicum ATCC 13032.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
RX   MEDLINE=22830012; PubMed=12948626; DOI=10.1016/S0168-1656(03)00154-8;
RA   Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M.,
RA   Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L.,
RA   Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B.,
RA   McHardy A.C., Meyer F., Moeckel B., Pfefferle W., Puehler A.,
RA   Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I.,
RA   Tauch A.;
RT   "The complete Corynebacterium glutamicum ATCC 13032 genome sequence
RT   and its impact on the production of L-aspartate-derived amino acids
RT   and vitamins.";
RL   J. Biotechnol. 104:5-25(2003).
CC   -!- FUNCTION: Has an important function as a repair enzyme for
CC       proteins that have been inactivated by oxidation. Catalyzes the
CC       reversible oxidation-reduction of methionine sulfoxide in proteins
CC       to methionine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide +
CC       H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CC   -!- CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H(2)O =
CC       L-methionine (S)-S-oxide + thioredoxin.
CC   -!- SIMILARITY: Belongs to the msrA Met sulfoxide reductase family.
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DR   EMBL; BA000036; BAC00320.1; -; Genomic_DNA.
DR   EMBL; BX927156; CAF20949.1; -; Genomic_DNA.
DR   RefSeq; NP_602113.1; -.
DR   RefSeq; YP_227165.1; -.
DR   HSSP; P54149; 1FVA.
DR   GeneID; 1020868; -.
DR   GeneID; 3343039; -.
DR   GenomeReviews; BA000036_GR; Cgl2926.
DR   GenomeReviews; BX927147_GR; cg3236.
DR   KEGG; cgb:cg3236; -.
DR   KEGG; cgl:NCgl2825; -.
DR   HOGENOM; Q8NLL5; -.
DR   OMA; Q8NLL5; YHQQYLD.
DR   BioCyc; CGLU196627-1:CG3236-MON; -.
DR   BRENDA; 1.8.4.11; 812.
DR   GO; GO:0008113; F:peptide-methionine-(S)-S-oxide reductase ac...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006464; P:protein modification process; IEA:HAMAP.
DR   HAMAP; MF_01401; -; 1.
DR   InterPro; IPR002569; MsrA.
DR   Gene3D; G3DSA:3.30.1060.10; MsrA; 1.
DR   Pfam; PF01625; PMSR; 1.
DR   ProDom; PD003489; PMSR; 1.
DR   TIGRFAMs; TIGR00401; msrA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Oxidoreductase.
FT   CHAIN         1    217       Peptide methionine sulfoxide reductase
FT                                msrA.
FT                                /FTId=PRO_0000138543.
FT   ACT_SITE     56     56       By similarity.
SQ   SEQUENCE   217 AA;  23931 MW;  D63AE2C3FED8019D CRC64;
     MAWFFAPEPV MVTADEALKG GRHPVLENPA PHTVLGTPVT GPWKEGQQRI WIGLGCFWGV
     EQMYWQMDGV EGTSVGYAGG FTPNPTYREV CSGRTGHTEI VEVVYDPSKI SLEQLVARGL
     EAHDPTQGFR QGNDVGTQYR SAYYTENEED AARVKAVVDA YGETLKQHGF GEITTEIGVI
     SPSDYFLAED YHQQYLDKNP DGYCPHHSTG IPCGVEA
//