Reviewed, UniProtKB/Swiss-Prot Q8NLL5 (MSRA_CORGL)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA
      Short name=Protein-methionine-S-oxide reductase
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase
      Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	Cgl2926, cg3236

Organism

Corynebacterium glutamicum (Brevibacterium flavum) [Complete proteome] [HAMAP]

Taxonomic identifier

1718 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Peptide methionine sulfoxide reductase msrA HAMAP MF_01401		PRO_0000138543
Sites
	Active site	56	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8NLL5-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: D63AE2C3FED8019D	FASTA	217	23,931
	10 20 30 40 50 60 MAWFFAPEPV MVTADEALKG GRHPVLENPA PHTVLGTPVT GPWKEGQQRI WIGLGCFWGV 70 80 90 100 110 120 EQMYWQMDGV EGTSVGYAGG FTPNPTYREV CSGRTGHTEI VEVVYDPSKI SLEQLVARGL 130 140 150 160 170 180 EAHDPTQGFR QGNDVGTQYR SAYYTENEED AARVKAVVDA YGETLKQHGF GEITTEIGVI 190 200 210 SPSDYFLAED YHQQYLDKNP DGYCPHHSTG IPCGVEA

References

[1]

"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032." Nakagawa S. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

[2]

"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins." Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A. J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000036 Genomic DNA. Translation: BAC00320.1. BX927156 Genomic DNA. Translation: CAF20949.1.
RefSeq	NP_602113.1. YP_227165.1.
3D structure databases
HSSP	HSSP built from PDB template 1FVA based on UniProtKB P54149.
ModBase	Search...
Genome annotation databases
GeneID	1020868. 3343039.
GenomeReviews	Gene locus Cgl2926 in contig BA000036_GR. Gene locus cg3236 in contig BX927147_GR.
KEGG	cgb:cg3236. cgl:NCgl2825.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8NLL5.
OMA	Q8NLL5. YHQQYLD.
Enzyme and pathway databases
BioCyc	CGLU196627-1:CG3236-MON.
BRENDA	1.8.4.11. 812.
Family and domain databases
HAMAP	MF_01401. [Tree]
InterPro	IPR002569. MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
ProDom	PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_CORGL

Accession

Primary (citable) accession number: Q8NLL5
Secondary accession number(s): Q6M1T9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)