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Q8NLC4

- SYL_CORGL

UniProt

Q8NLC4 - SYL_CORGL

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Protein

Leucine--tRNA ligase

Gene
leuS, Cgl3018, cg3346
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei725 – 7251ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCGLU196627:GJDM-2998-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Cgl3018, cg3346
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 952952Leucine--tRNA ligaseUniRule annotationPRO_0000152007Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196627.cg3346.

Structurei

3D structure databases

ProteinModelPortaliQ8NLC4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 7712"HIGH" regionUniRule annotationAdd
BLAST
Motifi722 – 7265"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiKGNPLES.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NLC4-1 [UniParc]FASTAAdd to Basket

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MTNPSEGTTP LAFRYTPELA NKIEGEWQNY WTDNGTFNAP NPVGDLAPAD    50
GKALPEDKLF VQDMFPYPSG AGLHVGHPLG YIATDVFARY NRMLGKNVLH 100
TLGYDAFGLP AEQYAIQTGT HPRTTTMANI ENMKRQLGAL GLGHDSRRAV 150
ATTDPEFYKW TQWIFLQIFN SWFDAEQQKA RPISELIPLL ESGELKTKDG 200
ADYNALGDVE KQKAVDDYRL VYRSNSTVNW CPGLGTVLAN EEVTADGRSE 250
RGNFPVFRKN LSQWMMRITA YSDRLIDDLE LLDWTEKVKS MQRNWIGRSR 300
GAEVDFSAEG ETVTVFTTRP DTLFGATYMV LAPEHELVDV LLEKAGSYEG 350
VDARWTNGQA SPAEAVAAYR ASIAAKSDLE RQENKEKTGV FLGVYATNPV 400
NGDQITVFIA DYVLTGYGTG AIMAVPAHDE RDYEFATVLG LPIKEVVAGG 450
NIEEAAFTES GEAVNSANDN GLDINGLAKD EAIAKTIEWL EEKELGRGTI 500
QYKLRDWLFA RQRYWGEPFP IVYDENGQAH ALPDSMLPVE LPEVEDYKPV 550
SFDPEDADSE PSPPLAKARE WVEVELDLGD GKKKYTRDTN VMPQWAGSSW 600
YQLRYVDPSN DEQFCNIENE RYWTGPRPET HGPNDPGGVD LYVGGVEHAV 650
LHLLYARFWH KVLFDLGHVS SKEPYRRLYN QGYIQAFAYT DSRGVYVPAD 700
DVEEKDGKFF YQGEEVNQEY GKMGKSLKNA VAPDDICNNF GADTLRVYEM 750
AMGPLDTSRP WATKDVVGAQ RFLQRLWRLV VDENTGEVLT RDEVLTDDDN 800
KQLHRTIAGV RDDYTNLRVN TVVAKLIEYV NYLTKTYPDT IPAGAVLPLI 850
VMVSPIAPHI AEELWKKLGH DDTVTYEPFP TFEEKWLTDD EIELPVQVNG 900
KVRGRITVAA DASQEQVIEA ALADEKVQEQ ISGKNLIKQI VVPGRMVNLV 950
VK 952
Length:952
Mass (Da):106,779
Last modified:October 1, 2002 - v1
Checksum:i3A1D2E2CD12D13E5
GO

Sequence cautioni

The sequence CAF18958.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000036 Genomic DNA. Translation: BAC00412.1.
BX927157 Genomic DNA. Translation: CAF18958.1. Different initiation.
RefSeqiNP_602213.1. NC_003450.3.
WP_011015573.1. NC_003450.3.
WP_011266058.1. NC_006958.1.
YP_227268.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAC00412; BAC00412; BAC00412.
CAF18958; CAF18958; cg3346.
GeneIDi1020959.
KEGGicgb:cg3346.
cgl:NCgl2915.
PATRICi21498090. VBICorGlu203724_2953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000036 Genomic DNA. Translation: BAC00412.1 .
BX927157 Genomic DNA. Translation: CAF18958.1 . Different initiation.
RefSeqi NP_602213.1. NC_003450.3.
WP_011015573.1. NC_003450.3.
WP_011266058.1. NC_006958.1.
YP_227268.1. NC_006958.1.

3D structure databases

ProteinModelPortali Q8NLC4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg3346.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC00412 ; BAC00412 ; BAC00412 .
CAF18958 ; CAF18958 ; cg3346 .
GeneIDi 1020959.
KEGGi cgb:cg3346.
cgl:NCgl2915.
PATRICi 21498090. VBICorGlu203724_2953.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi KGNPLES.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CGLU196627:GJDM-2998-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiSYL_CORGL
AccessioniPrimary (citable) accession number: Q8NLC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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